Detailed view for Smp_001170

Basic information

TDR Targets ID: 286430
Schistosoma mansoni, eukaryotic translation initiation factor 3 subunit 10 (theta)
Source Database / ID:  GeneDB

pI: 8.944 | Length (AA): 1047 | MW (Da): 121720 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF01399   PCI domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0005852   eukaryotic translation initiation factor 3 complex  

Metabolic Pathways

RNA transport (KEGG)

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
8 491 4u1d (C) 7 491 30.00 0 1 0.736873 -0.26
674 846 5cwg (A) 2 194 28.00 0.19 0.98 0.520834 -1.09
791 854 5wsu (C) 782 848 44.00 0.25 0.11 0.620727 -1.9
792 854 3v6i (B) 46 109 35.00 0.98 0.05 0.617772 -2.24

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_128741)

Species Accession Gene Product
Arabidopsis thaliana AT4G11420   eukaryotic translation initiation factor 3A
Babesia bovis BBOV_IV005090   translation initiation factor 3 subunit 10, putative
Brugia malayi Bm1_29045   eukaryotic translation initiation factor 3 subunit 10, putative
Candida albicans CaO19.6345   translation initiation factor eIF3
Candida albicans CaO19.13701   translation initiation factor eIF3
Caenorhabditis elegans CELE_C27D11.1   Protein EGL-45
Cryptosporidium hominis Chro.50354   hypothetical protein
Cryptosporidium parvum cgd5_390   putative eukaryotic translation initiation factor 3
Dictyostelium discoideum DDB_G0272078   eIF-3 theta
Drosophila melanogaster Dmel_CG9805   CG9805 gene product from transcript CG9805-RD
Echinococcus granulosus EgrG_000738200   eukaryotic translation initiation factor 3
Echinococcus multilocularis EmuJ_000738200   eukaryotic translation initiation factor 3
Homo sapiens ENSG00000107581   eukaryotic translation initiation factor 3, subunit A
Loa Loa (eye worm) LOAG_12041   eukaryotic translation initiation factor 3 subunit 10
Loa Loa (eye worm) LOAG_12797   hypothetical protein
Loa Loa (eye worm) LOAG_14815   hypothetical protein
Loa Loa (eye worm) LOAG_15533   hypothetical protein
Mus musculus ensembl-mmu:ENSMUSG00000024991   eukaryotic translation initiation factor 3, subunit A
Neospora caninum NCLIV_023050   eukaryotic translation initiation factor 3 subunit 10, putative
Oryza sativa 4326038   Os01g0120800
Plasmodium berghei PBANKA_1428700   eukaryotic translation initiation factor 3 subunit A, putative
Plasmodium falciparum PF3D7_1212700   eukaryotic translation initiation factor 3 subunit A, putative
Plasmodium knowlesi PKNH_1432100   eukaryotic translation initiation factor 3 subunit A, putative
Plasmodium vivax PVX_123340   eukaryotic translation initiation factor 3 subunit 10, putative
Plasmodium yoelii PY04546   eukaryotic translation initiation factor 3 subunit 10
Saccharomyces cerevisiae YBR079C   Rpg1p
Schistosoma japonicum Sjp_0300070   ko:K03254 translation initiation factor eIF-3 subunit 10, putative
Schistosoma mansoni Smp_001170   eukaryotic translation initiation factor 3 subunit 10 (theta)
Schmidtea mediterranea mk4.001846.07   Eukaryotic translation initiation factor 3 subunit A
Schmidtea mediterranea mk4.000912.08   Eukaryotic translation initiation factor 3 subunit A
Toxoplasma gondii TGME49_201680   eukaryotic initiation factor-3 subunit 10, putative
Theileria parva TP01_0235   eukaryotic translation initiation factor 3 subunit 10, putative
Trichomonas vaginalis TVAG_385550   conserved hypothetical protein

Essentiality

Smp_001170 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_C27D11.1 Caenorhabditis elegans embryonic lethal wormbase
CELE_C27D11.1 Caenorhabditis elegans larval arrest wormbase
CELE_C27D11.1 Caenorhabditis elegans slow growth wormbase
CELE_C27D11.1 Caenorhabditis elegans sterile wormbase
YBR079C Saccharomyces cerevisiae inviable yeastgenome
TGME49_201680 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Smp_001170 (Schistosoma mansoni), eukaryotic translation initiation factor 3 subunit 10 (theta)
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