Detailed view for Smp_131580

Basic information

TDR Targets ID: 286713
Schistosoma mansoni, lysosomal alpha-mannosidase (mannosidase alpha class 2b member 1), putative

Source Database / ID: SchistoDB.net / Smp_131580  GeneDB / Smp_131580

pI: 6.6367 | Length (AA): 953 | MW (Da): 109427 | Number of Paralogs: 2

EC number(s): 3.2.1.24 | Enzyme, KEGG, Brenda (mouse over to display more information)

Signal peptide: N | GPI Anchor: N (Show evidence) | Predicted trans-membrane segments: ND

Pfam domains

PF07748   Glyco_hydro_38C
PF09261   Alpha-mann_mid

Gene Ontology

Function: (mouse over links to read term descriptions)

GO:0003824   catalytic activity  
GO:0030246   carbohydrate binding  
GO:0015923   mannosidase activity  
GO:0008270   zinc ion binding  
GO:0004559   alpha-mannosidase activity  

Process: (mouse over links to read term descriptions)

GO:0006013   mannose metabolic process  
GO:0005975   carbohydrate metabolic process  
Metabolic Pathways

Other glycan degradation (KEGG)
Lysosome (KEGG)

Functional classes

No functional classes assigned to this gene.

Structural information

Modbase 3D models: Smp_131580  

PDB structures: no structure available for this protein in the PDB.

Expression

No expression information available for this gene.

Antigenicity

Number of putative antigenic epitopes: 43
Cumulative epitope score: 47.9
Normalized epitope score: 5.0
Percentile: 78.3 (this protein belongs to the top 21.7% proteins in the genome of Schistosoma mansoni, based on the predicted antigenicity).

[+/–]   More information on this prediction ...

Orthologs

OrthoMCL 4 cluster: OG4_12348
Number of Paralogs: 2

Ortholog group members from selected species:
Arabidopsis thaliana NP_201416   glycosyl hydrolase family 38 protein ... |   OrthoMCL
Arabidopsis thaliana NP_189306   glycosyl hydrolase family 38 protein ... |   OrthoMCL
Arabidopsis thaliana NP_196902   glycosyl hydrolase family 38 protein ... |   OrthoMCL
Arabidopsis thaliana NP_001118706   glycosyl hydrolase family 38 protein ... |   OrthoMCL
Arabidopsis thaliana NP_001031878   glycosyl hydrolase family 38 protein ... |   OrthoMCL
Arabidopsis thaliana NP_851037   glycosyl hydrolase family 38 protein ... |   OrthoMCL
Caenorhabditis elegans F55D10.1   CE28456 WBGene00018877 Alpha-mannosidase status:Partially_co... |   OrthoMCL
Drosophila melanogaster FBpp0079345   |   OrthoMCL
Drosophila melanogaster FBpp0079344   |   OrthoMCL
Drosophila melanogaster FBpp0079346   |   OrthoMCL
Drosophila melanogaster FBpp0079343   |   OrthoMCL
Drosophila melanogaster FBpp0079632   |   OrthoMCL
Drosophila melanogaster FBpp0079621   |   OrthoMCL
Homo sapiens ENSP00000395473   |   OrthoMCL
Mus musculus ENSMUSP00000034121   |   OrthoMCL
Oryza sativa NP_001067993   Os11g0525600 ... |   OrthoMCL
Oryza sativa NP_001064140   Os10g0140200 ... |   OrthoMCL
Schistosoma mansoni Smp_131580 (this record).   lysosomal alpha-mannosidase (mannosidase alpha class 2b memb... |   OrthoMCL
Trypanosoma brucei gambiense Tbg972.10.3200   |   OrthoMCL
Trypanosoma brucei Tb927.10.2570   lysosomal alpha-mannosidase precursor, putative... |   OrthoMCL
Trypanosoma cruzi Tc00.1047053506195.120   lysosomal alpha-mannosidase precursor, putative... |   OrthoMCL
Trypanosoma cruzi Tc00.1047053506407.10   lysosomal alpha-mannosidase precursor, putative... |   OrthoMCL
Trypanosoma vivax TvY486_1002590   |   OrthoMCL

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

Associated compounds / Druggability
  • Curated from literature

    No chemical compounds is associated to this gene

  • Predicted associations

  • Assayability

    Assay information

    No assay information for this target.

    Reagent availability

    No reagent availability information for this target.

    Bibliographic references

    No literature references are available for this gene.

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    User comments

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