Detailed view for Smp_000110

Basic information

TDR Targets ID: 286794
Schistosoma mansoni, similar to elongation factor Tu GTP binding domain containing 1 isoform 6-related
Source Database / ID:  GeneDB

pI: 7.0075 | Length (AA): 1281 | MW (Da): 141905 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00009   Elongation factor Tu GTP binding domain
PF00679   Elongation factor G C-terminus

Gene Ontology

Mouse over links to read term descriptions.
GO:0005525   GTP binding  
GO:0003924   GTPase activity  

Metabolic Pathways

Ribosome biogenesis in eukaryotes (KEGG)

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
19 240 5h7k (A) 7 213 38.00 0 1 0.480502 0.06
27 1222 5h7j (A) 16 735 29.00 0 1 0.358446 1.95
37 238 5w7q (A) 14 206 23.00 0 0.16 0.300489 -0.07
1219 1274 2gbj (A) 5 57 36.00 0.67 0.5 0.438916 -0.42

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_128278)

Species Accession Gene Product
Arabidopsis thaliana AT3G22980   ribosomal protein S5/Elongation factor G/III/V family protein
Babesia bovis BBOV_IV003290   Elongation factor Tu-like protein
Brugia malayi Bm1_18155   Elongation factor Tu GTP binding domain containing protein
Candida albicans CaO19.11931   translation elongation factor EF4
Candida albicans CaO19.4451   translation elongation factor EF4
Caenorhabditis elegans CELE_K10C3.5   Protein K10C3.5, isoform A
Cryptosporidium hominis Chro.60456   elongation factor-like protein
Cryptosporidium parvum cgd6_3960   elongation factor-like protein
Dictyostelium discoideum DDB_G0279689   band 7 family protein
Drosophila melanogaster Dmel_CG33158   CG33158 gene product from transcript CG33158-RB
Echinococcus granulosus EgrG_001009200   elongation factor Tu GTP binding
Entamoeba histolytica EHI_155660   Elongation factor 2, putative
Echinococcus multilocularis EmuJ_001009200   elongation factor Tu GTP binding
Homo sapiens ENSG00000140598   elongation factor Tu GTP binding domain containing 1
Leishmania braziliensis LbrM.25.1640   elongation factor 2-like protein
Leishmania donovani LdBPK_252160.1   elongation factor 2-like protein
Leishmania infantum LinJ.25.2160   elongation factor 2-like protein
Leishmania major LmjF.25.2080   elongation factor 2-like protein
Leishmania mexicana LmxM.25.2080   elongation factor 2-like protein
Loa Loa (eye worm) LOAG_05140   hypothetical protein
Mus musculus ENSMUSG00000038563   elongation factor Tu GTP binding domain containing 1
Neospora caninum NCLIV_037640   elongation factor Tu GTP-binding domain- containing protein, putative
Oryza sativa 4333588   Os03g0650700
Oryza sativa 4329604   Os02g0543300
Onchocerca volvulus OVOC11807  
Plasmodium berghei PBANKA_1361100   elongation factor Tu, putative
Plasmodium falciparum PF3D7_1348300   elongation factor Tu, putative
Plasmodium knowlesi PKNH_1252600   elongation factor Tu, putative
Plasmodium vivax PVX_083310   translation elongation factor, putative
Plasmodium yoelii PY02627   Elongation factor Tu family, putative
Saccharomyces cerevisiae YNL163C   GTPase RIA1
Schistosoma japonicum Sjp_0004390   ko:K03234 elongation factor EF-2, putative
Schistosoma japonicum Sjp_0113280   Elongation factor Tu GTP-binding domain-containing protein 1, putative
Schistosoma mansoni Smp_000110   similar to elongation factor Tu GTP binding domain containing 1 isoform 6-related
Schmidtea mediterranea mk4.004643.00  
Schmidtea mediterranea mk4.004204.01  
Trypanosoma brucei gambiense Tbg972.3.2120   translation elongation factor EF-2, putative
Trypanosoma brucei Tb927.3.2170   translation elongation factor EF-2, putative
Trypanosoma congolense TcIL3000_3_1280   translation elongation factor EF-2, putative
Trypanosoma cruzi TcCLB.504077.40   translation elongation factor EF-2, putative
Trypanosoma cruzi TcCLB.507081.30   translation elongation factor EF-2, putative
Toxoplasma gondii TGME49_268710   elongation factor Tu GTP binding domain-containing protein
Theileria parva TP01_1088   elongation factor Tu, putative
Trichomonas vaginalis TVAG_109490   116 kD U5 small nuclear ribonucleoprotein component, putative

Essentiality

Smp_000110 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.3.2170 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.3.2170 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (6 days) alsford
Tb927.3.2170 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.3.2170 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
YNL163C Saccharomyces cerevisiae inviable yeastgenome
PBANKA_1361100 Plasmodium berghei Essential plasmo
TGME49_268710 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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User comments

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Gene identifier Smp_000110 (Schistosoma mansoni), similar to elongation factor Tu GTP binding domain containing 1 isoform 6-related
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