Detailed view for Smp_036990

Basic information

TDR Targets ID: 287084
Schistosoma mansoni, sh3-containing grb2-like protein 3 (endophilin III)
Source Database / ID:  GeneDB

pI: 5.6988 | Length (AA): 365 | MW (Da): 41663 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF03114   BAR domain
PF14604   Variant SH3 domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0005737   cytoplasm  
GO:0005515   protein binding  
GO:0006897   endocytosis  

Metabolic Pathways

Endocytosis (KEGG)

Structural information

Modbase 3D models:

There are 8 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
11 253 2d4c (A) 11 251 47.00 0 1 1.07415 -0.84
30 257 2z0v (A) 7 228 47.00 0 1 1.24646 -0.83
294 365 2dl8 (A) 1 69 33.00 0 1 0.53166 -0.73
302 363 3c0c (A) 305 366 60.00 0 1 0.999663 -1.41
305 358 2rf0 (A) 18 77 46.00 0 1 0.592345 -1.2
306 361 1jo8 (A) 1 58 48.00 0.000018 1 0.818225 -1.26
309 355 6gbu (E) 7 56 57.00 0 0.44 0.388167 0.49
310 356 2vge (A) 765 814 43.00 0.0067 0.93 0.604567 -0.24

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_129271)

Species Accession Gene Product
Brugia malayi Bm1_55210   BAR domain containing protein
Caenorhabditis elegans CELE_T04D1.3   Protein UNC-57, isoform B
Dictyostelium discoideum DDB_G0285851   hypothetical protein
Drosophila melanogaster Dmel_CG14296   Endophilin A
Echinococcus granulosus EgrG_000903800   sh3 containing grb2 protein 3
Echinococcus granulosus EgrG_001064500   endophilin A3
Echinococcus multilocularis EmuJ_001064500   endophilin A3
Echinococcus multilocularis EmuJ_000050400   endophilin A3
Echinococcus multilocularis EmuJ_001064400   nostrin
Echinococcus multilocularis EmuJ_000015600   transfer RNA-Ala
Echinococcus multilocularis EmuJ_000903800   sh3 containing grb2 protein 3
Homo sapiens ENSG00000107295   SH3-domain GRB2-like 2
Homo sapiens ENSG00000140600   SH3-domain GRB2-like 3
Homo sapiens ENSG00000141985   SH3-domain GRB2-like 1
Loa Loa (eye worm) LOAG_06772   BAR domain-containing protein
Mus musculus 20408   SH3-domain GRB2-like 3
Mus musculus ENSMUSG00000028488   SH3-domain GRB2-like 2
Mus musculus ENSMUSG00000003200   SH3-domain GRB2-like 1
Oryza sativa 4336533   Os04g0539800
Schistosoma japonicum Sjp_0035450   ko:K00680 SH3-domain GRB2-like 1 [EC:2.3.1.-], putative
Schistosoma mansoni Smp_036990   sh3-containing grb2-like protein 3 (endophilin III)
Schmidtea mediterranea mk4.016193.00  
Schmidtea mediterranea mk4.003666.02  
Schmidtea mediterranea mk4.003683.01  
Schmidtea mediterranea mk4.003683.05  
Schmidtea mediterranea mk4.002457.01   Endophilin-A
Schmidtea mediterranea mk4.001235.07   Endophilin-A
Schmidtea mediterranea mk4.000997.05   Endophilin-A
Schmidtea mediterranea mk4.016193.03  
Schmidtea mediterranea mk4.011270.00   Endophilin-A
Schmidtea mediterranea mk4.000045.00   Endophilin-A
Schmidtea mediterranea mk4.002364.00  

Essentiality

Smp_036990 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_T04D1.3 Caenorhabditis elegans embryonic arrest wormbase
Show/Hide essentiality data references
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

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Gene identifier Smp_036990 (Schistosoma mansoni), sh3-containing grb2-like protein 3 (endophilin III)
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