Detailed view for Smp_019890

Basic information

TDR Targets ID: 287171
Schistosoma mansoni, syntaxin
Source Database / ID:  GeneDB

pI: 5.0116 | Length (AA): 261 | MW (Da): 29962 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 1

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00804   Syntaxin
PF05739   SNARE domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0017157   regulation of exocytosis  
GO:0005484   SNAP receptor activity  
GO:0000149   SNARE binding  
GO:0016021   integral to membrane  
GO:0016020   membrane  
GO:0005515   protein binding  
GO:0016192   vesicle-mediated transport  
GO:0006886   intracellular protein transport  

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1 120 3lg7 (A) 5 124 45.00 0 1 1.20157 -2.57
1 218 4jeh (B) 30 247 62.00 0 1 1.75075 -2.03
148 227 1l4a (B) 180 259 82.00 0 0.43 1.08331 0.47
159 257 3hd7 (F) 188 286 72.00 0 0.89 1.06281 1.18

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_126868)

Species Accession Gene Product
Arabidopsis thaliana AT4G03330   syntaxin-123
Arabidopsis thaliana AT1G11250   syntaxin-125
Arabidopsis thaliana AT1G61290   syntaxin-124
Arabidopsis thaliana AT3G03800   syntaxin of plants 131
Babesia bovis BBOV_III003750   SNARE domain containing protein
Brugia malayi Bm1_13855   SNARE domain containing protein
Brugia malayi Bm1_35065   SNARE domain containing protein
Brugia malayi Bm1_13690   Syntaxin
Candida albicans CaO19.1376   similar to syntaxin
Candida albicans CaO19.8956   similar to syntaxin
Caenorhabditis elegans CELE_F56A8.7   Protein UNC-64, isoform A
Cryptosporidium hominis Chro.20126   syntaxin
Cryptosporidium parvum cgd2_1140   syntaxin, putative, SMART syntaxin+tSNARE+transmembrane domain or GPI anchor at C-terminus
Dictyostelium discoideum DDB_G0289379   t-SNARE family protein
Dictyostelium discoideum DDB_G0270556   t-SNARE family protein
Drosophila melanogaster Dmel_CG31136   Syntaxin 1A
Echinococcus granulosus EgrG_000746800   syntaxin 1a
Echinococcus granulosus EgrG_000213200   syntaxin 1a
Echinococcus granulosus EgrG_000749400   syntaxin
Echinococcus granulosus EgrG_000213300   syntaxin
Entamoeba histolytica EHI_139030   syntaxin, putative
Echinococcus multilocularis EmuJ_000213300   syntaxin
Echinococcus multilocularis EmuJ_000749400   syntaxin
Echinococcus multilocularis EmuJ_000746800   syntaxin 1a
Echinococcus multilocularis EmuJ_000213200   syntaxin 1a
Giardia lamblia GL50803_96994   Syntaxin 1A
Homo sapiens ENSG00000111450   syntaxin 2
Homo sapiens ENSG00000166900   syntaxin 3
Homo sapiens ENSG00000099365   syntaxin 1B
Homo sapiens ENSG00000106089   syntaxin 1A (brain)
Leishmania braziliensis LbrM.28.1630   Qa-SNARE protein
Leishmania braziliensis LbrM.28.1640   Qa-SNARE protein
Leishmania infantum LinJ.28.1600   Qa-SNARE protein
Leishmania major LmjF.28.1470   Qa-SNARE protein
Leishmania major LmjF.28.1480   Qa-SNARE protein
Leishmania mexicana LmxM.28.1470   Qa-SNARE protein
Loa Loa (eye worm) LOAG_08017   SNARE domain-containing protein
Loa Loa (eye worm) LOAG_06570   syntaxin A
Loa Loa (eye worm) LOAG_15550   hypothetical protein
Loa Loa (eye worm) LOAG_14682   SNARE domain-containing protein
Loa Loa (eye worm) LOAG_13588   hypothetical protein
Mus musculus ENSMUSG00000029428   syntaxin 2
Mus musculus ENSMUSG00000007207   syntaxin 1A (brain)
Mus musculus ENSMUSG00000041488   syntaxin 3
Mus musculus 56216   syntaxin 1B
Neospora caninum NCLIV_004070   hypothetical protein
Oryza sativa 4341413   Os06g0590500
Oryza sativa 9272269   Os02g0209900
Oryza sativa 4340257   Os06g0168500
Oryza sativa 4342474   Os07g0164300
Onchocerca volvulus OVOC5748  
Plasmodium berghei PBANKA_0307600   syntaxin, putative
Plasmodium falciparum PF3D7_0210700   syntaxin, Qa-SNARE family
Plasmodium knowlesi PKNH_0410500   syntaxin, putative
Plasmodium vivax PVX_003985   syntaxin, putative
Plasmodium vivax PVX_253300   unspecified product
Saccharomyces cerevisiae YPL232W   Sso1p
Saccharomyces cerevisiae YMR183C   Sso2p
Schistosoma japonicum Sjp_0218380   ko:K04560 syntaxin 1A, putative
Schistosoma mansoni Smp_019890   syntaxin
Schmidtea mediterranea mk4.006204.00   Syntaxin-1A homolog
Schmidtea mediterranea mk4.004386.01   Syntaxin-1A
Schmidtea mediterranea mk4.022376.00  
Schmidtea mediterranea mk4.013939.00   Putative syntaxin
Trypanosoma brucei gambiense Tbg972.11.9830   target SNARE, putative,syntaxin, putative
Trypanosoma brucei Tb927.11.8790   target SNARE, putative
Trypanosoma congolense TcIL3000_0_03040   target SNARE, putative
Trypanosoma congolense TcIL3000.11.9100   target SNARE, putative
Trypanosoma cruzi TcCLB.506587.60   target SNARE, putative
Trypanosoma cruzi TcCLB.506929.40   target SNARE, putative
Toxoplasma gondii TGME49_209820   syntaxin protein
Theileria parva TP02_0230   hypothetical protein
Trichomonas vaginalis TVAG_070550   syntaxin, putative

Essentiality

Smp_019890 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb11.12.0013 Trypanosoma brucei significant gain of fitness in bloodstream forms (3 days) alsford
Tb11.12.0013 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (6 days) alsford
Tb11.12.0013 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb11.12.0013 Trypanosoma brucei significant gain of fitness in differentiation of procyclic to bloodstream forms alsford
Show/Hide essentiality data references
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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Gene identifier Smp_019890 (Schistosoma mansoni), syntaxin
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