Detailed view for Smp_039400

Basic information

TDR Targets ID: 287724
Schistosoma mansoni, initiation factor 5a
Source Database / ID:  GeneDB

pI: 5.3242 | Length (AA): 160 | MW (Da): 17752 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF01287   Eukaryotic elongation factor 5A hypusine, DNA-binding OB fold

Gene Ontology

Mouse over links to read term descriptions.
GO:0003746   translation elongation factor activity  
GO:0003723   RNA binding  
GO:0043022   ribosome binding  
GO:0008612   peptidyl-lysine modification to hypusine  
GO:0006452   translational frameshifting  
GO:0045905   positive regulation of translational termination  
GO:0045901   positive regulation of translational elongation  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 2 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
13 159 3er0 (A) 12 155 56.00 0 1 1.57105 -0.37
16 158 5hy6 (A) 16 156 54.00 0 1 1.58695 -0.8

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_126922)

Species Accession Gene Product
Arabidopsis thaliana AT1G69410   eukaryotic translation initiation factor 5A-3
Arabidopsis thaliana AT1G13950   translation initiation factor eIF-5A
Arabidopsis thaliana AT1G26630   eukaryotic translation initiation factor 5A-2
Babesia bovis BBOV_IV008910   translation initiation factor 5A, putative
Brugia malayi Bm1_57565   Eukaryotic translation initiation factor 5A-2
Candida albicans CaO19.10930   similar to both S. cerevisiae versions of hypusine-containing translation initiation factor eIF-5A, putative sensor of intracell
Candida albicans CaO19.3426   similar to both S. cerevisiae versions of hypusine-containing translation initiation factor eIF-5A, putative sensor of intracell
Caenorhabditis elegans CELE_F54C9.1   Protein IFF-2
Caenorhabditis elegans CELE_T05G5.10   Protein IFF-1, isoform C
Cryptosporidium hominis Chro.70262   translation initiation factor 5A2
Cryptosporidium parvum cgd7_2300   translation initiation factor if-5A
Dictyostelium discoideum DDB_G0284861   eukaryotic translation initiation factor 5A
Drosophila melanogaster Dmel_CG3186   CG3186 gene product from transcript CG3186-RB
Echinococcus granulosus EgrG_000749800   eukaryotic translation initiation factor 5A
Entamoeba histolytica EHI_186480   translation initiation factor eIF-5A, putative
Entamoeba histolytica EHI_177460   translation initiation factor eIF-5A, putative
Entamoeba histolytica EHI_151540   translation initiation factor eIF-5A, putative
Entamoeba histolytica EHI_151810   translation initiation factor eIF-5A, putative
Echinococcus multilocularis EmuJ_000749800   eukaryotic translation initiation factor 5A
Giardia lamblia GL50803_14614   Eukaryotic translation initiation factor 5A
Homo sapiens ENSG00000132507   eukaryotic translation initiation factor 5A
Homo sapiens ENSG00000163577   eukaryotic translation initiation factor 5A2
Homo sapiens ENSG00000253626   eukaryotic translation initiation factor 5A-like 1
Leishmania braziliensis LbrM.25.0580   eukaryotic initiation factor 5a, putative
Leishmania braziliensis LbrM.25.0590   eukaryotic initiation factor 5a, putative
Leishmania braziliensis LbrM.25.0600   eukaryotic initiation factor 5a, putative
Leishmania braziliensis LbrM.25.0610   eukaryotic initiation factor 5a, putative
Leishmania donovani LdBPK_250740.1   eukaryotic initiation factor 5a, putative
Leishmania donovani LdBPK_250750.1   eukaryotic initiation factor 5a, putative
Leishmania infantum LinJ.25.0750   eukaryotic initiation factor 5a, putative
Leishmania infantum LinJ.25.0760   eukaryotic initiation factor 5a, putative
Leishmania infantum LinJ.25.0740   eukaryotic initiation factor 5a, putative
Leishmania major LmjF.25.0720   eukaryotic initiation factor 5a, putative
Leishmania major LmjF.25.0730   eukaryotic initiation factor 5a, putative
Leishmania mexicana LmxM.25.0730   eukaryotic initiation factor 5a, putative
Leishmania mexicana LmxM.25.0720   eukaryotic initiation factor 5a, putative
Loa Loa (eye worm) LOAG_01764   eukaryotic translation initiation factor 5A-2
Mus musculus ENSMUSG00000078812   eukaryotic translation initiation factor 5A
Mus musculus ENSMUSG00000050192   eukaryotic translation initiation factor 5A2
Neospora caninum NCLIV_066870   hypothetical protein
Oryza sativa 4342241   Os07g0112800
Oryza sativa 4343796   Os07g0597000
Oryza sativa 9268063   Os07g0236250
Oryza sativa 4352300   Os12g0507200
Oryza sativa 4334177   Os03g0758800
Onchocerca volvulus OVOC11437   Eukaryotic translation initiation factor 5A homolog
Plasmodium berghei PBANKA_0603200   eukaryotic translation initiation factor 5A, putative
Plasmodium falciparum PF3D7_1204300   eukaryotic translation initiation factor 5A
Plasmodium knowlesi PKNH_1304000   eukaryotic translation initiation factor 5A, putative
Plasmodium vivax PVX_084255   eukaryotic translation initiation factor 5A
Plasmodium yoelii PY00983   translation initiation factor eIF-5A
Saccharomyces cerevisiae YJR047C   translation elongation factor eIF-5A
Saccharomyces cerevisiae YEL034W   translation elongation factor eIF-5A
Schistosoma japonicum Sjp_0017450   ko:K03263 translation initiation factor eIF-5A, putative
Schistosoma mansoni Smp_039400   initiation factor 5a
Schmidtea mediterranea mk4.004989.01   Eukaryotic translation initiation factor 5A
Schmidtea mediterranea mk4.004632.01   Eukaryotic translation initiation factor 5A
Schmidtea mediterranea mk4.001678.01   Eukaryotic translation initiation factor 5A
Schmidtea mediterranea mk4.003167.00   Eukaryotic translation initiation factor 5A
Schmidtea mediterranea mk4.006418.02   Eukaryotic translation initiation factor 5A
Schmidtea mediterranea mk4.002434.00   Eukaryotic translation initiation factor 5A
Trypanosoma brucei gambiense Tbg972.11.740   eukaryotic translation initiation factor 5a, putative
Trypanosoma brucei Tb927.11.740   eukaryotic translation initiation factor 5A
Trypanosoma cruzi TcCLB.506925.120   eukaryotic translation initiation factor 5A
Trypanosoma cruzi TcCLB.506925.130   eukaryotic translation initiation factor 5A
Toxoplasma gondii TGME49_251810   translation initiation factor eIF-5A, putative
Theileria parva TP01_0884   eukaryotic translation initiation factor 5A, putative
Trichomonas vaginalis TVAG_361780   initiation factor 5A, putative
Trichomonas vaginalis TVAG_283020   initiation factor 5A, putative

Essentiality

Smp_039400 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb11.03.0410 Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb11.03.0410 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb11.03.0410 Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb11.03.0410 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_T05G5.10 Caenorhabditis elegans embryonic lethal wormbase
CELE_T05G5.10 Caenorhabditis elegans sterile wormbase
CELE_F54C9.1 Caenorhabditis elegans embryonic lethal wormbase
CELE_F54C9.1 Caenorhabditis elegans larval arrest wormbase
CELE_F54C9.1 Caenorhabditis elegans slow growth wormbase
CELE_F54C9.1 Caenorhabditis elegans sterile wormbase
YEL034W Saccharomyces cerevisiae inviable yeastgenome
TGME49_251810 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Smp_039400 (Schistosoma mansoni), initiation factor 5a
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