Detailed view for Smp_130640
Basic information
Schistosoma mansoni, hypothetical protein
Source Database / ID: GeneDB
pI: 8.4809 |
Length (AA): 1446 |
MW (Da): 162949 |
Paralog Number:
1
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Network
Gene Ontology
GO:0005515 protein binding
GO:0004198 calcium-dependent cysteine-type endopeptidase activity
GO:0006508 proteolysis
Metabolic Pathways
Structural information
Modbase 3D models:
PDB Structures:
Expression
Orthologs
Ortholog group members (OG5_152929)
| Species | Accession | Gene Product |
|---|---|---|
| Echinococcus granulosus | EgrG_000167200 | Activating transcription factor 7 interacting |
| Echinococcus multilocularis | EmuJ_000167200 | Activating transcription factor 7 interacting |
| Schistosoma japonicum | Sjp_0052880 | IPR008957,Fibronectin, type III-like fold,domain-containing |
| Schistosoma japonicum | Sjp_0034850 | IPR000048,IQ calmodulin-binding region,domain-containing |
| Schistosoma japonicum | Sjp_0052870 | similar to Uncharacterized protein C6orf103, putative |
| Schistosoma mansoni | Smp_146980 | hypothetical protein |
| Schistosoma mansoni | Smp_130640 | hypothetical protein |
Essentiality
Phenotypes and Validation (curated)
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Annotated validation
Associated compounds / Druggability
Known modulators for this target
Predicted associations
By orthology with druggable targets
By sequence similarity to non orthologous druggable targets
Obtained from network model
Ranking Plot
Putative Drugs List
Assayability
Assay information
Reagent availability
Bibliographic References