Detailed view for Smp_059340.3

Basic information

TDR Targets ID: 287745
Schistosoma mansoni, Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)

Source Database / ID: SchistoDB.net / Smp_059340.3  GeneDB / Smp_059340.3

pI: 6.9958 | Length (AA): 286 | MW (Da): 33664 | Paralog Number: 4

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: ND

Pfam domains

PF00503   G-protein alpha subunit

Gene Ontology

Mouse over links to read term descriptions.
GO:0031683   G-protein beta/gamma-subunit binding  
GO:0019001   guanyl nucleotide binding  
GO:0005525   GTP binding  
GO:0004871   signal transducer activity  
GO:0003924   GTPase activity  
GO:0007186   G-protein coupled receptor protein signaling pathway  
GO:0007165   signal transduction  

Network

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models: 0

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_131088)
Species Accession Gene Product
Brugia malayi Bm1_48675   GTP-binding regulatory protein Gs alpha-S chain, putative
Caenorhabditis elegans CELE_R06A10.2   Protein GSA-1
Drosophila melanogaster Dmel_CG2835   G protein alpha s subunit
Echinococcus granulosus EgrG_000677700   guanine nucleotide binding protein Gs subunit
Echinococcus granulosus EgrG_000149800   guanine nucleotide binding protein Gs subunit
Echinococcus multilocularis EmuJ_000677700   guanine nucleotide binding protein G(s) subunit
Echinococcus multilocularis EmuJ_000149800   guanine nucleotide binding protein G(s) subunit
Homo sapiens ENSG00000087460   GNAS complex locus
Homo sapiens ENSG00000141404   guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type
Loa Loa (eye worm) LOAG_05696   GTP-binding regulatory protein Gs alpha-S chain
Mus musculus ENSMUSG00000024524   guanine nucleotide binding protein, alpha stimulating, olfactory type
Mus musculus ENSMUSG00000027523   GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus
Schistosoma japonicum Sjp_0302810   ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative
Schistosoma mansoni Smp_059340.3 this record   Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)
Schistosoma mansoni Smp_059340.1   Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)
Schistosoma mansoni Smp_059340.2   Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)
Schmidtea mediterranea mk4.001118.01   Protein ALEX
Schmidtea mediterranea mk4.000734.12   Protein ALEX
Schmidtea mediterranea mk4.000136.06   Protein ALEX
Schmidtea mediterranea mk4.001118.00   Guanine nucleotide-binding protein G(olf) subunit alpha
Schmidtea mediterranea mk4.003459.03  
Schmidtea mediterranea mk4.000136.15   Protein ALEX
Schmidtea mediterranea mk4.000986.00   Protein ALEX
Schmidtea mediterranea mk4.000734.13   Protein ALEX
Schmidtea mediterranea mk4.000734.05   Protein ALEX
Schmidtea mediterranea mk4.003459.04   Protein ALEX
Schmidtea mediterranea mk4.000026.09   Guanine nucleotide-binding protein G(olf) subunit alpha
Schmidtea mediterranea mk4.000734.04   Protein ALEX
Schmidtea mediterranea mk4.000026.08   Guanine nucleotide-binding protein G(olf) subunit alpha
Schmidtea mediterranea mk4.000734.06  

Essentiality

Smp_059340.3 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_R06A10.2 Caenorhabditis elegans larval lethal wormbase
CELE_R06A10.2 Caenorhabditis elegans slow growth wormbase
CELE_R06A10.2 Caenorhabditis elegans sterile wormbase

Show/Hide essentiality data references
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Curated from literature

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens GNAS complex locus Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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User comments

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Gene identifier Smp_059340.3 (Schistosoma mansoni), Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)
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TDR Targets Development Release v6, Revision: 1335 (10.Aug.2018)
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