Detailed view for Smp_127170

Basic information

TDR Targets ID: 288099
Schistosoma mansoni, twik family of potassium channels-related
Source Database / ID:  GeneDB

pI: 9.2781 | Length (AA): 558 | MW (Da): 64003 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 5

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF07885   Ion channel

Gene Ontology

Mouse over links to read term descriptions.
GO:0071805   GO:potassium ion transmembrane transport  

GO:0016020   membrane  
GO:0005267   potassium channel activity  
GO:0006813   potassium ion transport  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 7 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
231 551 3ukm (A) 64 281 37.00 0.0000000001 0.82 0.200869 1.93
242 354 4twk (A) 115 213 38.00 0.000000072 0.78 0.380109 1.27
258 323 3beh (A) 154 219 24.00 0 0.02 0.21898 1.06
264 554 6cq6 (A) 127 308 36.00 0.000000036 0.92 0.215105 1.55
265 337 2a79 (B) 360 419 42.00 0.35 0.14 0.193424 1.48
452 551 3ukm (A) 182 281 34.00 0 0.39 0.464911 0.38
454 540 3ldc (A) 18 96 29.00 0 0.11 0.336614 -0.15

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_138457)

Species Accession Gene Product
Brugia malayi Bm1_11495   Twik (KCNK-like) family of potassium channels, alpha subunit 39A
Brugia malayi Bm1_17635   Twik (KCNK-like) family of potassium channels, alpha subunit 39B
Caenorhabditis elegans CELE_C24H11.8   Protein TWK-39, isoform B
Drosophila melanogaster Dmel_CG9194   CG9194 gene product from transcript CG9194-RA
Echinococcus granulosus EgrG_000394800   potassium channel subfamily K 8
Echinococcus multilocularis EmuJ_000394800   potassium channel subfamily K 8
Loa Loa (eye worm) LOAG_08131   hypothetical protein
Loa Loa (eye worm) LOAG_14908   hypothetical protein
Loa Loa (eye worm) LOAG_08130   hypothetical protein
Loa Loa (eye worm) LOAG_08567   hypothetical protein
Onchocerca volvulus OVOC7588  
Onchocerca volvulus OVOC7587  
Schistosoma japonicum Sjp_0077390   Potassium channel subfamily K member 18, putative
Schistosoma japonicum Sjp_0077400   hypothetical protein
Schistosoma mansoni Smp_127170   twik family of potassium channels-related
Schmidtea mediterranea mk4.000775.00   Twik family of potassium channels-related
Schmidtea mediterranea mk4.028628.00   Twik family of potassium channels-related
Schmidtea mediterranea mk4.026518.00   Twik family of potassium channels-related

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Smp_127170 (Schistosoma mansoni), twik family of potassium channels-related
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