Detailed view for Smp_141290.4

Basic information

TDR Targets ID: 288660
Schistosoma mansoni, innexin
Source Database / ID:  GeneDB

pI: 8.1531 | Length (AA): 458 | MW (Da): 52476 | Paralog Number: 8

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 4

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00876   Innexin

Gene Ontology

Mouse over links to read term descriptions.
GO:0005921   gap junction  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_134759)

Species Accession Gene Product
Drosophila melanogaster Dmel_CG34358   shaking B
Echinococcus granulosus EgrG_000527700   Innexin unc 7
Echinococcus granulosus EgrG_000249400   innexin unc 9
Echinococcus granulosus EgrG_000501300   innexin unc 9
Echinococcus granulosus EgrG_000838500   innexin unc 9
Echinococcus granulosus EgrG_001000000   innexin unc 9
Echinococcus granulosus EgrG_000249500   innexin unc 9
Echinococcus granulosus EgrG_000501100   innexin unc 9
Echinococcus granulosus EgrG_000628300   Innexin unc 7
Echinococcus granulosus EgrG_000755500   innexin unc 9
Echinococcus granulosus EgrG_000448500   innexin unc 9
Echinococcus granulosus EgrG_000500900   innexin unc 9
Echinococcus granulosus EgrG_000249300   innexin
Echinococcus granulosus EgrG_000448600   innexin unc 9
Echinococcus granulosus EgrG_000501000   Innexin unc 7
Echinococcus multilocularis EmuJ_000501000   Innexin unc 7
Echinococcus multilocularis EmuJ_000501100   innexin unc 9
Echinococcus multilocularis EmuJ_000838500   innexin unc 9
Echinococcus multilocularis EmuJ_000755500   innexin unc 9
Echinococcus multilocularis EmuJ_000249400   innexin unc 9
Echinococcus multilocularis EmuJ_000500900   Innexin unc 7
Echinococcus multilocularis EmuJ_000249300   innexin
Echinococcus multilocularis EmuJ_000501300   innexin unc 9
Echinococcus multilocularis EmuJ_000448600   innexin unc 9
Echinococcus multilocularis EmuJ_000448500   innexin unc 9
Echinococcus multilocularis EmuJ_000628300   Innexin unc 7
Echinococcus multilocularis EmuJ_000527700   Innexin unc 7
Echinococcus multilocularis EmuJ_000249500   innexin unc 9
Echinococcus multilocularis EmuJ_001000000   innexin unc 9
Schistosoma japonicum Sjp_0114320   Innexin unc-7, putative
Schistosoma japonicum Sjp_0210170   Innexin unc-9, putative
Schistosoma japonicum Sjp_0057750   Innexin unc-7, putative
Schistosoma japonicum Sjp_0217790   Innexin unc-9, putative
Schistosoma japonicum Sjp_0101240   Innexin unc-9, putative
Schistosoma japonicum Sjp_0056560   Innexin unc-9, putative
Schistosoma japonicum Sjp_0056580   IPR000990,Innexin,domain-containing
Schistosoma japonicum Sjp_0022030   IPR000990,Innexin,domain-containing
Schistosoma japonicum Sjp_0078510   Innexin unc-9, putative
Schistosoma mansoni Smp_066900   innexin
Schistosoma mansoni Smp_141390   innexin
Schistosoma mansoni Smp_088060   innexin
Schistosoma mansoni Smp_129020   innexin
Schistosoma mansoni Smp_141290.1   innexin
Schistosoma mansoni Smp_026570   innexin
Schistosoma mansoni Smp_141290.4   innexin
Schistosoma mansoni Smp_141290.2   innexin
Schistosoma mansoni Smp_141290.3   innexin
Schmidtea mediterranea mk4.010437.02  
Schmidtea mediterranea mk4.027828.00  
Schmidtea mediterranea mk4.000508.07  
Schmidtea mediterranea mk4.018450.00  
Schmidtea mediterranea mk4.034920.00  
Schmidtea mediterranea mk4.003924.00   Innexin
Schmidtea mediterranea mk4.006352.02  
Schmidtea mediterranea mk4.013838.01  
Schmidtea mediterranea mk4.000508.05  
Schmidtea mediterranea mk4.006443.00  
Schmidtea mediterranea mk4.013953.00  
Schmidtea mediterranea mk4.032463.01  
Schmidtea mediterranea mk4.003776.05  
Schmidtea mediterranea mk4.004555.01  
Schmidtea mediterranea mk4.008688.05  
Schmidtea mediterranea mk4.001831.00   Innexin
Schmidtea mediterranea mk4.001862.01  
Schmidtea mediterranea mk4.006363.01  
Schmidtea mediterranea mk4.002195.03  
Schmidtea mediterranea mk4.008013.02  
Schmidtea mediterranea mk4.003183.01  
Schmidtea mediterranea mk4.019606.00  
Schmidtea mediterranea mk4.004230.05  
Schmidtea mediterranea mk4.006044.00  
Schmidtea mediterranea mk4.000558.04  
Schmidtea mediterranea mk4.001497.00  
Schmidtea mediterranea mk4.002172.02  
Schmidtea mediterranea mk4.008352.02  
Schmidtea mediterranea mk4.013992.00   Putative innexin
Schmidtea mediterranea mk4.003227.00  
Schmidtea mediterranea mk4.022514.01  
Schmidtea mediterranea mk4.042243.00  
Schmidtea mediterranea mk4.000088.00  
Schmidtea mediterranea mk4.019284.00  
Schmidtea mediterranea mk4.002670.04  
Schmidtea mediterranea mk4.030876.00  
Schmidtea mediterranea mk4.002676.03  
Schmidtea mediterranea mk4.022208.00   Innexin
Schmidtea mediterranea mk4.000939.06  
Schmidtea mediterranea mk4.012369.00  
Schmidtea mediterranea mk4.002184.03  
Schmidtea mediterranea mk4.030734.00   Innexin
Schmidtea mediterranea mk4.003183.03  
Schmidtea mediterranea mk4.016133.01  
Schmidtea mediterranea mk4.005181.00  
Schmidtea mediterranea mk4.000052.00  
Schmidtea mediterranea mk4.016955.00  
Schmidtea mediterranea mk4.001106.01  
Schmidtea mediterranea mk4.021592.01  
Schmidtea mediterranea mk4.021145.02  
Schmidtea mediterranea mk4.010666.00   Innexin
Schmidtea mediterranea mk4.000052.01  
Schmidtea mediterranea mk4.002083.10  
Schmidtea mediterranea mk4.005742.03   Innexin
Schmidtea mediterranea mk4.006171.00  
Schmidtea mediterranea mk4.018543.00  
Schmidtea mediterranea mk4.017090.01  
Schmidtea mediterranea mk4.000101.01  
Schmidtea mediterranea mk4.005912.00  
Schmidtea mediterranea mk4.000460.06  
Schmidtea mediterranea mk4.035780.00  
Schmidtea mediterranea mk4.011655.01  
Schmidtea mediterranea mk4.023477.00  
Schmidtea mediterranea mk4.025172.00   Innexin
Schmidtea mediterranea mk4.027495.00   Innexin
Schmidtea mediterranea mk4.000558.02  
Schmidtea mediterranea mk4.016629.00  
Schmidtea mediterranea mk4.002184.04  
Schmidtea mediterranea mk4.043312.00   Innexin
Schmidtea mediterranea mk4.009142.01  
Schmidtea mediterranea mk4.005358.00  
Schmidtea mediterranea mk4.026278.00  
Schmidtea mediterranea mk4.022244.00   Innexin
Schmidtea mediterranea mk4.002063.05  
Schmidtea mediterranea mk4.023412.00  
Schmidtea mediterranea mk4.014105.01   Innexin
Schmidtea mediterranea mk4.001112.02  
Schmidtea mediterranea mk4.000251.01  
Schmidtea mediterranea mk4.017135.00   Innexin
Schmidtea mediterranea mk4.000007.09  
Schmidtea mediterranea mk4.003367.01  
Schmidtea mediterranea mk4.018410.00  
Schmidtea mediterranea mk4.042908.00  
Schmidtea mediterranea mk4.027823.01  
Schmidtea mediterranea mk4.020850.01  

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Smp_141290.4 (Schistosoma mansoni), innexin
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