Detailed view for Smp_000990

Basic information

TDR Targets ID: 289561
Schistosoma mansoni, exocyst complex component 1
Source Database / ID:  GeneDB

pI: 5.5574 | Length (AA): 780 | MW (Da): 88294 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF09763   Exocyst complex component Sec3

Gene Ontology

Mouse over links to read term descriptions.
GO:0000145   exocyst  
GO:0006887   exocytosis  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
2 677 1z3h (A) 192 859 11.00 0 1 0.897267 0.31
183 386 3edv (A) 1763 1968 9.00 0 0.17 0.333338 -0.27
193 390 4tql (A) 9 209 10.00 0.4 0.21 0.387646 -0.67

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_130112)

Species Accession Gene Product
Arabidopsis thaliana AT1G47560   exocyst complex component sec3B
Arabidopsis thaliana AT1G47550   exocyst complex component sec3A
Brugia malayi Bm1_39330   Probable exocyst complex component Sec3
Caenorhabditis elegans CELE_F52E4.7   Protein SEC-3
Dictyostelium discoideum DDB_G0285067   exocyst complex subunit 1
Drosophila melanogaster Dmel_CG3885   Sec3 ortholog (S. cerevisiae)
Echinococcus granulosus EgrG_001048900   exocyst complex component 1
Echinococcus multilocularis EmuJ_001048900   exocyst complex component 1
Homo sapiens ENSG00000090989   exocyst complex component 1
Loa Loa (eye worm) LOAG_09420   hypothetical protein
Mus musculus ENSMUSG00000036435   exocyst complex component 1
Oryza sativa 4350273   Os11g0276000
Oryza sativa 4333493   Os03g0625700
Schistosoma japonicum Sjp_0205640   Exocyst complex component 1, putative
Schistosoma japonicum Sjp_0132580   expressed protein
Schistosoma japonicum Sjp_0205620   expressed protein
Schistosoma japonicum Sjp_0205630   expressed protein
Schistosoma mansoni Smp_000990   exocyst complex component 1
Schmidtea mediterranea mk4.024968.00  
Schmidtea mediterranea mk4.035519.00   Exocyst complex component 1
Schmidtea mediterranea mk4.013168.00  
Schmidtea mediterranea mk4.013168.03   Exocyst complex component 1
Schmidtea mediterranea mk4.013168.01  
Schmidtea mediterranea mk4.013168.04   Exocyst complex component 1
Schmidtea mediterranea mk4.035519.01   Exocyst complex component 1

Essentiality

Smp_000990 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_F52E4.7 Caenorhabditis elegans embryonic lethal wormbase
CELE_F52E4.7 Caenorhabditis elegans slow growth wormbase
Show/Hide essentiality data references
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Smp_000990 (Schistosoma mansoni), exocyst complex component 1
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