Detailed view for Smp_000480

Basic information

TDR Targets ID: 290419
Schistosoma mansoni, eukaryotic translation initiation factor 3 subunit 8
Source Database / ID:  GeneDB

pI: 5.8447 | Length (AA): 869 | MW (Da): 100219 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF05470   Eukaryotic translation initiation factor 3 subunit 8 N-terminus

Gene Ontology

Mouse over links to read term descriptions.
GO:0031369   translation initiation factor binding  
GO:0005852   eukaryotic translation initiation factor 3 complex  
GO:0005783   endoplasmic reticulum  
GO:0003743   translation initiation factor activity  
GO:0003723   RNA binding  
GO:0006413   translational initiation  

Metabolic Pathways

RNA transport (KEGG)

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
46 230 4uos (A) 1 183 11.00 0.0019 0.04 0.330288 -0.69
113 180 2qb7 (A) 96 168 38.00 0.87 0.55 0.385351 0.46
301 822 4u1c (C) 251 794 29.00 0 1 0.87709 -0.02

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_127970)

Species Accession Gene Product
Arabidopsis thaliana AT3G56150   eukaryotic translation initiation factor 3 subunit C
Arabidopsis thaliana AT3G22860   eukaryotic translation initiation factor 3 subunit C2
Babesia bovis BBOV_III008380   eukaryotic translation initiation factor 3 subunit 8, putative
Brugia malayi Bm1_08520   eukaryotic translation initiation factor 3 subunit 8, putative
Candida albicans CaO19.12105   subunit of translation initiation complex eIF3
Candida albicans CaO19.4635   subunit of translation initiation complex eIF3
Caenorhabditis elegans CELE_T23D8.4   Protein EIF-3.C
Cryptosporidium hominis Chro.40430   eukaryotic translation initiation factor 3 subunit 8
Cryptosporidium parvum cgd4_3770   conserved hypothetical protein
Dictyostelium discoideum DDB_G0279109   eIF-3 p110
Drosophila melanogaster Dmel_CG4954   CG4954 gene product from transcript CG4954-RB
Echinococcus granulosus EgrG_000128100   eukaryotic translation initiation factor 3
Entamoeba histolytica EHI_140610   hypothetical protein
Echinococcus multilocularis EmuJ_000128100   eukaryotic translation initiation factor 3
Homo sapiens ENSG00000205609   eukaryotic translation initiation factor 3, subunit C-like
Homo sapiens ENSG00000184110   eukaryotic translation initiation factor 3, subunit C
Leishmania braziliensis LbrM.35.7360   eukaryotic translation initiation factor 3 subunit 8, putative
Leishmania donovani LdBPK_367320.1   eukaryotic translation initiation factor 3 subunit c
Leishmania infantum LinJ.36.7320   eukaryotic translation initiation factor 3 subunit 8, putative
Leishmania major LmjF.36.6980   eukaryotic translation initiation factor 3 subunit 8, putative
Leishmania mexicana LmxM.36.6980   eukaryotic translation initiation factor 3 subunit 8, putative
Loa Loa (eye worm) LOAG_01539   eukaryotic translation initiation factor 3 subunit 8
Mus musculus ENSMUSG00000030738   eukaryotic translation initiation factor 3, subunit C
Neospora caninum NCLIV_001520   Eukaryotic translation initiation factor 3 subunit C, related
Oryza sativa 4328137   Os02g0123300
Oryza sativa 4342306   Os07g0124500
Plasmodium berghei PBANKA_0604800   eukaryotic translation initiation factor 3 subunit C, putative
Plasmodium falciparum PF3D7_1206200   eukaryotic translation initiation factor 3 subunit C, putative
Plasmodium knowlesi PKNH_1305900   eukaryotic translation initiation factor 3 subunit C, putative
Plasmodium vivax PVX_084345   eukaryotic translation initiation factor 3 subunit 8, putative
Plasmodium yoelii PY00916   eukaryotic translation initiation factor 3 subunit 8
Saccharomyces cerevisiae YMR309C   Nip1p
Schistosoma japonicum Sjp_0219750   Eukaryotic translation initiation factor 3 subunit C, putative
Schistosoma mansoni Smp_000480   eukaryotic translation initiation factor 3 subunit 8
Schmidtea mediterranea mk4.000093.09   Eukaryotic translation initiation factor 3 subunit C
Schmidtea mediterranea mk4.000093.11   Eukaryotic translation initiation factor 3 subunit C
Schmidtea mediterranea mk4.000105.02   Eukaryotic translation initiation factor 3 subunit C
Schmidtea mediterranea mk4.000105.03  
Trypanosoma brucei gambiense Tbg972.10.10100  
Trypanosoma brucei Tb927.10.8270   eukaryotic translation initiation factor 3 subunit c
Trypanosoma brucei Tb927.10.8290   eukaryotic translation initiation factor 3 subunit c
Trypanosoma brucei Tb11.v5.0877   eukaryotic translation initiation factor 3 subunit 8, putative
Trypanosoma congolense TcIL3000_10_7150   eukaryotic translation initiation factor 3 subunit c
Trypanosoma cruzi TcCLB.507723.130   eukaryotic translation initiation factor 3 subunit c
Trypanosoma cruzi TcCLB.507611.310   eukaryotic translation initiation factor 3 subunit c
Toxoplasma gondii TGME49_294620   eukaryotic initiation factor-3, subunit 8, putative
Theileria parva TP04_0739   eukaryotic translation initiation factor 3 subunit 8, putative
Trichomonas vaginalis TVAG_184380   conserved hypothetical protein

Essentiality

Smp_000480 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.10.8270 Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb927.10.8270 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb927.10.8270 Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb927.10.8270 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_T23D8.4 Caenorhabditis elegans sterile wormbase
YMR309C Saccharomyces cerevisiae inviable yeastgenome
PBANKA_0604800 Plasmodium berghei Essential plasmo
TGME49_294620 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Smp_000480 (Schistosoma mansoni), eukaryotic translation initiation factor 3 subunit 8
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