Detailed view for LmjF.15.0870

Basic information

TDR Targets ID: 29066
Leishmania major, hypothetical protein, conserved
Source Database / ID:  TriTrypDB  GeneDB

pI: 7.7512 | Length (AA): 620 | MW (Da): 66253 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 8

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00083   Sugar (and other) transporter

Gene Ontology

Mouse over links to read term descriptions.
GO:0022857   transmembrane transporter activity  
GO:0016021   integral to membrane  
GO:0055085   transmembrane transport  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
416 590 2cfq (A) 9 187 16.00 0 0.09 0.53 -1.39
46 255 4tph (A) 9 219 12.00 0.0000087 0.04 0.42611 -0.04
260 373 2gqb (A) 14 122 36.00 0.1 0.46 0.206071 1.04

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile amastigotes, metacyclic. Fernandes MC
Show/Hide expression data references
  • Fernandes MC Dual Transcriptome Profiling of Leishmania-Infected Human Macrophages Reveals Distinct Reprogramming Signatures.

Orthologs

Ortholog group members (OG5_133806)

Species Accession Gene Product
Leishmania braziliensis LbrM.15.0900   hypothetical protein, conserved
Leishmania donovani LdBPK_150930.1   Sugar (and other) transporter, putative
Leishmania infantum LinJ.15.0930   hypothetical protein, conserved
Leishmania major LmjF.15.0870   hypothetical protein, conserved
Leishmania mexicana LmxM.15.0870   hypothetical protein, conserved
Neospora caninum NCLIV_053830   hypothetical protein, conserved
Plasmodium berghei PBANKA_0942100   metabolite/drug transporter, putative
Plasmodium falciparum PF3D7_1104800   metabolite/drug transporter, putative
Plasmodium knowlesi PKNH_0902400   metabolite/drug transporter, putative
Plasmodium vivax PVX_090920   metabolite/drug transporter, putative
Plasmodium yoelii PY02384   hypothetical protein
Trypanosoma brucei gambiense Tbg972.9.3340   hypothetical protein, conserved
Trypanosoma brucei gambiense Tbg972.9.3350   hypothetical protein, conserved
Trypanosoma brucei Tb927.9.6380   hypothetical protein, conserved
Trypanosoma brucei Tb927.9.6370   hypothetical protein, conserved
Trypanosoma brucei Tb927.9.6360   hypothetical protein, conserved
Trypanosoma cruzi TcCLB.506579.50   hypothetical protein, conserved
Trypanosoma cruzi TcCLB.506509.10   hypothetical protein, conserved
Trypanosoma cruzi TcCLB.506579.40   hypothetical protein, conserved
Toxoplasma gondii TGME49_309580   transporter, major facilitator family protein

Essentiality

LmjF.15.0870 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb09.v2.0030 Trypanosoma brucei significant gain of fitness in bloodstream forms (3 days) alsford
Tb09.v2.0030 Trypanosoma brucei significant gain of fitness in bloodstream forms (6 days) alsford
Tb09.v2.0030 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb09.v2.0030 Trypanosoma brucei significant gain of fitness in differentiation of procyclic to bloodstream forms alsford
Tb09.160.4630 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb09.160.4630 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb09.160.4630 Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb09.160.4630 Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
Tb09.v2.0020 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb09.v2.0020 Trypanosoma brucei significant gain of fitness in bloodstream forms (6 days) alsford
Tb09.v2.0020 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb09.v2.0020 Trypanosoma brucei significant gain of fitness in differentiation of procyclic to bloodstream forms alsford
PBANKA_0942100 Plasmodium berghei Essential plasmo
TGME49_309580 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0886 0.3725 1
0.092 0.3639 1
0.0737 0.7131 1
0.0785 0.7428 1
0.0855 0.4048 1
0.0372 0.3723 1
0.0746 0.2979 1
0.0805 0.3768 1
0.0938 0.3795 1
0.0902 0.3872 1
0.0808 0.4976 1
0.0905 0.392 1
0.0072 0.5 0.5
0.089 0.2727 1
0.0802 0.3726 1
0.0934 0.3952 1
0.0684 0.661 1
0.0744 0.3371 1
0.0708 0.6913 1
0.0006 0.5 0.5
0.0026 0.2589 0.5
0.0019 0.3675 0.5
0.0869 0.3805 1
0.0933 0.3903 1
0.0861 0.3665 1
0.0703 0.282 0.5
0.0784 0.766 1
0.0932 0.3859 1
0.0801 0.5193 0.789
0.0242 1 1
0.0849 0.3822 1
0.0808 0.3589 1
0.0906 0.4211 1
0.0904 0.385 1
0.0852 0.3794 1
0.0676 0.4278 0.427
0.0912 0.3836 1
0.0725 0.3007 0.5
0.0851 0.3655 1
0.0902 0.384 1
0.0681 0.282 0.5
0.0115 0.8254 0.5
0.0778 0.2723 0
0.0701 0.6657 1
0.0872 0.3682 1
0.0856 0.3829 1
0.0852 0.3669 1
0.0891 0.3748 1
0.0692 0.2863 0.5
0.0888 0.4111 1
0.0778 0.2723 0
0.0699 0.3137 1
0.0878 0.4008 1
0.0759 0.7344 1
0.0863 0.3613 1
0.0565 0.513 1
0.0779 0.2877 1
0.0808 0.7747 1
0.0919 0.3894 1
0.0883 0.4017 1
0.0847 0.3728 1
0.0006 0.5 0.5
0.088 0.3774 1
0.0898 0.388 1
0.09 0.368 1
0.0832 0.3853 1
0.0911 0.3866 1
0.0104 0.4448 0.5
0.0859 0.3676 1
0.0954 0.378 1
0.0822 0.3544 1
0.0152 0.339 0
0.0919 0.4066 1
0.0604 0.5795 1
0.0882 0.383 1
0.0661 0.3105 1
0.0693 0.2676 0.5
0.0785 0.3546 1
0.0955 0.3879 1
0.0801 0.3587 1
0.0086 0.5 0.5
0.0026 0.4542 0.5
0.0757 0.2571 1
0.0862 0.3709 1
0.0909 0.3804 1
0.0808 0.3589 1
0.0859 0.3889 1
0.0801 0.5193 0.789
0.0911 0.3937 1
0.0786 0.3708 1
0.0006 0.5 0.5
0.0815 0.3701 1
0.0814 0.3388 0.5
0.0904 0.3997 1
0.0705 0.673 1
0.0693 0.3086 1
0.0788 0.3469 1
0.0771 0.3215 0.5
0.0761 0.7227 1
0.0906 0.3708 1
0.0917 0.76 1
0.0933 0.3971 1
0.0006 0.5 0.5
0.0838 0.798 1
0.0887 0.3854 1
0.082 0.3993 1
0.0017 0.5 0.5
0.0825 0.381 1
0.0676 0.4278 0.427
0.0846 0.3834 1
0.0885 0.38 1
0.0867 0.3611 1
0.0856 0.3899 1
0.0691 0.6563 1
0.0877 0.3703 1
0.0855 0.3965 1
0.0825 0.395 1
0.0908 0.4056 1
0.0649 0.5 0.5
0.0904 0.388 1
0.08 0.3562 1
0.0931 0.4131 1
0.0839 0.3687 1
0.0811 0.3835 1
0.0026 0.5 0.5
0.0778 0.2723 0
0.09 0.3856 1
0.0115 0.8254 0.5
0.0746 0.2979 1
0.0473 0.4582 1
0.0218 0.2749 0.9089
0.0824 0.7893 1
0.0906 0.4211 1
0.0006 0.5 0.5
0.0835 0.7944 1
0.0879 0.3794 1
0.0676 0.4278 0.427
0.0006 0.5 0.5
0.0788 0.3469 1
0.0779 0.7604 1
0.0848 0.3654 1
0.0006 0.5 0.5
0.0395 0.4327 1
0.0215 1 1
0.0901 0.3833 1
0.0124 0.5 0.5
0.0731 0.7159 1
0.0662 0.6327 1
0.0006 0.5 0.5
0.0937 0.3983 1
0.0766 0.3381 1
0.0026 0.5 0.5
0.0785 0.3546 1
0.0869 0.3613 1
0.0443 0.5 0.5
0.0614 0.4905 1
0.0891 0.4065 1
0.086 0.4118 1
0.0828 0.3611 1
0.0701 0.6673 1
0.0947 0.3919 1
0.0731 0.6098 1
0.0945 0.3769 1
0.0916 0.4286 1
0.0931 0.3822 1
0.0858 0.3951 1
0.0789 0.351 1
0.0851 0.3655 1
0.0006 0.5 0.5
0.0602 0.2622 1
0.0006 0.5 0.5
0.001 0.5 0.5
0.0885 0.3952 1
0.0854 0.368 1
0.0052 0.3137 0.6893
0.0859 0.3771 1
0.0934 0.355 1
0.0931 0.4131 1
0.0801 0.3419 1
0.0967 0.3866 1
0.0705 0.2788 0.5
0.0866 0.3965 1
0.0858 0.401 1
0.0778 0.2723 0
0.0875 0.4019 1
0.0636 0.5945 1
0.0943 0.4376 1
0.0766 0.3381 1
0.0016 0.5 0.5
0.0924 0.363 1
0.0782 0.3584 1
0.0872 0.3879 1
0.0902 0.3808 1
0.0731 0.7159 1
0.0836 0.4016 1
0.0578 0.5 0.5
0.0913 0.4084 1
0.0893 0.3833 1
0.0906 0.3653 1
0.038 0.5 0.5
0.0881 0.4196 1
0.0006 0.5 0.5

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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Gene identifier LmjF.15.0870 (Leishmania major), hypothetical protein, conserved
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