Detailed view for Smp_106230

Basic information

TDR Targets ID: 291894
Schistosoma mansoni, hypothetical protein
Source Database / ID:  GeneDB

pI: 5.4985 | Length (AA): 147 | MW (Da): 15504 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

No Pfam domain information for this protein.

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_131813)

Species Accession Gene Product
Brugia malayi Bm1_14755   Nuclear hormone receptor family member nhr-25
Brugia malayi Bm1_33595   Nuclear hormone receptor family member nhr-25
Caenorhabditis elegans CELE_F11C1.6   Protein NHR-25, isoform A
Drosophila melanogaster Dmel_CG4059   ftz transcription factor 1
Echinococcus granulosus EgrG_000814300   FTZ F1 nuclear receptor protein
Echinococcus multilocularis EmuJ_000814300   FTZ F1 nuclear receptor protein
Echinococcus multilocularis EmuJ_000763500   FTZ F1 alpha
Homo sapiens ENSG00000116833   nuclear receptor subfamily 5, group A, member 2
Loa Loa (eye worm) LOAG_02263   hypothetical protein
Mus musculus ENSMUSG00000026398   nuclear receptor subfamily 5, group A, member 2
Schistosoma japonicum Sjp_0022650   ko:K08027 nuclear receptor, subfamily 5, group A, member 2, putative
Schistosoma mansoni Smp_068780   FTZ-F1 nuclear receptor-like protein
Schistosoma mansoni Smp_106230   hypothetical protein
Schmidtea mediterranea mk4.000915.03   Nuclear hormone receptor family member nhr-25

Essentiality

Smp_106230 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_F11C1.6 Caenorhabditis elegans embryonic lethal wormbase
CELE_F11C1.6 Caenorhabditis elegans larval lethal wormbase
CELE_F11C1.6 Caenorhabditis elegans slow growth wormbase
CELE_F11C1.6 Caenorhabditis elegans sterile wormbase
Show/Hide essentiality data references
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens nuclear receptor subfamily 5, group A, member 2 Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0099 0.8513 0.8513
0.0079 0.8617 0.8617

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Smp_106230 (Schistosoma mansoni), hypothetical protein
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