Detailed view for Smp_000130.3

Basic information

TDR Targets ID: 292043
Schistosoma mansoni, hormone-sensitive lipase (S09 family)
Source Database / ID:  GeneDB

pI: 7.2964 | Length (AA): 772 | MW (Da): 87660 | Paralog Number: 2

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF06350   Hormone-sensitive lipase (HSL) N-terminus
PF07859   alpha/beta hydrolase fold

Gene Ontology

Mouse over links to read term descriptions.
GO:0016787   hydrolase activity  
GO:0016298   lipase activity  
GO:0016042   lipid catabolic process  
GO:0008203   cholesterol metabolic process  
GO:0008152   metabolic process  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 7 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
318 767 3wj1 (A) 2 305 26.00 0 1 0.364102 0.9
335 604 4krx (A) 29 301 23.00 0 1 0.690941 -0.4
348 759 1jji (A) 45 308 31.00 0 1 0.264879 1
371 763 5jd4 (A) 64 313 28.00 0 1 0.211267 0.99
386 498 4kry (E) 83 195 40.00 0 1 0.712173 -1.13
389 505 1jji (A) 81 203 41.00 0 1 0.650354 -0.56
543 764 4v2i (A) 92 315 14.00 0 0.34 0.474865 -0.32

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_132840)

Species Accession Gene Product
Caenorhabditis elegans CELE_C46C11.1   Protein C46C11.1, isoform B
Drosophila melanogaster Dmel_CG11055   Hormone-sensitive lipase ortholog
Echinococcus granulosus EgrG_000966500   hormone sensitive lipase
Echinococcus multilocularis EmuJ_000966500   hormone sensitive lipase
Homo sapiens ENSG00000079435   lipase, hormone-sensitive
Loa Loa (eye worm) LOAG_10499   hypothetical protein
Mus musculus ENSMUSG00000003123   lipase, hormone sensitive
Schistosoma japonicum Sjp_0004410   ko:K07188 hormone-sensitive lipase [EC3.1.1.79], putative
Schistosoma japonicum Sjp_0309390   Hormone-sensitive lipase, putative
Schistosoma japonicum Sjp_0004400   Hormone-sensitive lipase, putative
Schistosoma mansoni Smp_000130.3   hormone-sensitive lipase (S09 family)
Schistosoma mansoni Smp_000130.1   hormone-sensitive lipase (S09 family)
Schistosoma mansoni Smp_000130.4   hormone-sensitive lipase (S09 family)
Schmidtea mediterranea mk4.006383.00   Hormone-sensitive lipase
Schmidtea mediterranea mk4.018220.00  
Schmidtea mediterranea mk4.006208.00  
Schmidtea mediterranea mk4.017527.00  
Schmidtea mediterranea mk4.010063.00  

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens lipase, hormone-sensitive Compounds References
Rattus norvegicus Hormone-sensitive lipase Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0506 1 1
1.4997 1 1
1.7812 1 1
0.0253 0.5 0.5
0.2809 0.4986 0.4986
0.3194 0.4141 0.4625
0.0253 0.9598 1
0.1328 1 1
0.4566 1 1
0.0207 0.5034 1
0.0215 0.3214 0.6098
0.2862 0.6598 0.6598
0.0506 1 1
0.2388 0.5 0.5
0.1318 0.322 0.4629
0.3388 0.4325 0.7725
0.0226 0.2603 0.6799
0.0411 1 1
0.0506 0.2607 0.2607
0.0908 1 1
0.0866 1 1
0.0891 0.4126 1
0.0421 1 1
0.0416 0.6 0.5975
0.083 1 1
0.6704 0.3896 0.3896
1.1937 1 1
1.6994 1 1
0.0251 0.4683 0.4683
0.2912 1 0.5
0.1127 1 1
0.4024 1 1
0.329 1 1
0.0864 1 1
0.0978 0.2832 0.7781
0.0253 1 1
0.0477 0.2623 0.5234
0.0253 1 1
0.3853 1 1
0.3056 1 1
0.1087 1 1
1.8558 1 1
0.3 1 1
0.6823 0.5 0.5
0.2018 1 1
0.0253 1 1
0.2194 0.5 0.5
0.0172 0.6509 1
0.0506 1 0.5
0.0928 1 1
0.2601 0.2702 0.2702
0.0213 0.7911 0.7911
1.1091 1 1
0.0253 1 1
0.0253 1 1
0.0506 1 1
0.0203 0.2861 0.2861
0.0253 0.5 0.5
0.0456 0.2547 0.2991
0.0253 0.5 0.5
0.0415 0.5223 1
0.0672 0.7083 0.8347
0.1087 1 1
0.2333 1 1
0.0253 0.5 0.5
0.0413 0.9017 1
0.3388 0.4325 0.7725
0.351 0.4505 0.4504
0.2388 0.5 0.5
0.1488 1 1
0.1269 0.4764 0.4764
1.9604 1 1
1.7785 1 1
0.5957 0.3577 0.3572
0.0253 0.5 0.5
0.1945 1 1
0.0928 1 1
0.0506 1 1
1.0272 1 1
0.0253 0.862 1
0.0223 0.3138 0.9209
0.0205 0.2529 1
0.782 1 1
0.1328 1 1
0.0251 0.4683 0.4683
0.0409 0.5636 0.5621
0.1132 1 1
0.0627 1 1
0.1125 1 1
1.7812 1 1
1.0643 1 1
0.0506 1 1
0.3388 0.4325 0.7725
0.0506 0.7827 0.7827
1.7785 1 1
0.786 1 1
0.0647 1 0.5
0.8545 1 1
0.1912 0.8626 0.8625
0.3004 1 1
0.2152 1 1
0.0253 0.5 0.5
0.2708 1 1
1.7756 1 1
0.0203 0.5091 1
0.069 0.6975 1
0.1636 1 1
1.9604 1 1
0.2204 1 1
0.4939 1 1
0.1314 1 1
0.021 0.3625 1
0.0253 0.5 0.5
0.0653 1 1
0.26 1 1
0.3194 0.4141 0.4625
0.3388 0.4325 0.7725
0.3388 0.4325 0.7725
0.1981 1 1
0.0253 0.5 0.5
1.9604 1 1
0.0204 0.6385 1
0.3194 0.4141 0.4625
0.0506 0.5 0.5
0.0207 0.4346 0.4346
0.0631 0.6283 1
0.4521 1 1
0.0253 0.6865 0.6865
0.0692 1 0.5
0.1318 0.322 0.4629
0.0398 0.5 0.5
0.0897 0.4941 0.4936
0.3 1 1
1.7812 1 1
0.0926 1 1
0.8075 1 1
0.0233 0.6377 1
0.0431 0.4538 1
0.0506 0.7836 0.7836
0.0374 0.8693 0.8687
0.3388 0.4325 0.7725
0.1388 1 1
0.0475 1 1
0.0253 1 1
0.0253 0.5 0.5
0.042 0.4229 0.6371
0.786 1 1
0.0627 0.7104 0.9317
0.0613 0.7774 1
1.0272 1 1
0.0506 0.5 0.5
0.0253 0.5 0.5
1.9604 1 1
0.0253 0.3049 0.697
0.0253 0.5 0.5
0.0842 0.6701 0.6701
0.1064 1 1
1.6092 1 1
0.233 0.9422 1
0.0443 1 1
1.2041 1 1
0.0253 1 1
0.0226 0.4526 0.6434
0.1132 1 1
0.0429 0.499 1
0.0253 1 1
0.0207 0.2577 1
0.0204 0.8847 1
0.3388 0.4325 0.7725
0.8545 1 1
1.503 1 1
0.3506 0.5252 0.5252
0.0456 0.4585 1
0.3194 0.4141 0.4625
0.203 1 1
0.0329 0.3838 0.4568
1.0158 1 1
0.2387 1 1
0.1832 0.8702 1
0.0444 1 1
0.1608 1 1
1.7785 1 1
0.1059 0.5 0.5
0.0425 0.2656 1
1.7821 1 1
0.0253 0.5 0.5
0.0506 1 1
0.1616 1 1
0.0506 0.4894 0.4894
0.1832 0.8702 1
1.6994 1 1
0.0253 0.5 0.5
0.3496 1 1
0.3194 0.4141 0.4625
0.1139 1 1
0.269 1 0.5
0.0614 0.5 0.5
0.3 1 1
0.1107 1 1
0.0475 1 1
0.1305 1 1
0.696045 1 1
1.4997 1 1
0.042 1 1
0.0704 1 1
0.0419 0.8256 1
1.3808 1 1
1.8836 1 1
0.0205 0.4526 1
0.0669 1 1
1.5212 1 1
0.0186 1 1
0.0253 1 1
0.26 1 1
0.0394 1 1
1.9454 1 1
1.5212 1 1
0.0928 1 1
0.0709 1 1
0.0232 0.3708 0.9336
0.5323 1 1
0.027 0.8448 1
0.1116 0.7541 1
0.0506 0.268 0.2676
0.1517 0.6967 0.6967
1.4997 1 1
0.1101 0.7096 0.7096
0.0421 1 1
0.3495 0.7606 0.7606
0.0253 0.5 0.5
0.0253 1 1
0.0928 1 1
0.5223 1 1
0.0875 1 1
0.1569 0.6514 1
0.1126 0.5 0.5
0.0413 0.5047 1
0.7149 1 1
0.0419 0.5 0.5
0.0506 1 1
0.0638 0.2554 0.7191
0.0247 0.5725 0.5
0.329 1 1
0.0794 0.3111 1
0.0506 0.5 0.5
0.0215 0.4576 0.5634
0.0407 0.445 1
0.0253 0.5 0.5
0.3388 0.4325 0.7725
0.1087 1 1
0.4224 1 1
0.0506 1 1
0.0122856 0.399942 1
0.0506 0.5139 0.5139
0.0506 1 1
0.179 0.5 0.5
0.351 0.4505 0.4504
0.1139 1 1
0.0253 1 1
0.0253 0.5 0.5
0.0226 0.2603 0.6799
1.7812 1 1
0.1897 0.2946 0.2946
1.503 1 1
0.0442 0.4327 0.5204
0.0226 0.4526 0.6434
0.0411 0.4661 1
0.0253 0.5 0.5
0.0893 0.2724 0.3186
0.0253 0.6865 0.6865
0.7149 1 1
0.0425 0.2656 1
0.0214 0.3556 1
0.0253 1 1
0.209 1 1
0.0216 0.2921 0.2921
0.0312 0.4435 1
1.9604 1 1
0.5704 1 1
0.0464 0.5192 1
0.2279 1 1
0.1171 0.3239 0.3239
0.0442 0.5 0.5
0.0236 0.9006 0.9006
0.2957 1 1
0.0213 1 1
1.3689 1 1
0.1576 1 1
0.1132 1 1
0.0253 0.5 0.5
0.0506 0.5171 1
0.2862 0.6598 0.6598
0.0898 0.5 0.5
0.4566 1 1
0.2543 1 1
0.0253 0.5 0.5
0.3194 0.4141 0.4625
1.6472 1 1
0.216 0.2955 0.2955
0.0253 0.5 0.5
0.0253 0.5 0.5
0.0213 0.3777 0.3777
0.3228 0.5 0.5
0.0556156 0.863178 1
0.0839 0.4911 1
1.1854 1 1
0.322 1 1
0.0253 0.5 0.5
0.0253 0.5 0.5
1.0272 1 1
0.5714 1 1
0.0506 1 1
0.0486 1 1
0.3194 0.4141 0.4625
0.0218 0.6561 0.9865
0.0653 1 1
0.1185 0.4379 0.4692
0.0206 0.7873 1
0.2601 0.2702 0.2702
0.3424 1 1
0.0253 0.5 0.5
0.0253 0.5 0.5
1.1528 1 1
0.0253 0.5 0.5
0.0205 0.4435 1
0.0254 1 1
0.1087 1 1
0.0506 0.5 0.5
0.1245 1 1
0.0253 0.5 0.5
0.1544 0.5 0.5
0.1318 0.322 0.4629
0.1318 0.322 0.4629
1.0272 1 1
0.0336 0.9897 1
0.0172 0.6509 1
0.0506 1 1
0.0603 1 1
0.1485 0.3082 0.5514
0.2459 1 1
0.1832 0.8702 1
0.124922 1 1
0.063 0.3777 0.8812
0.0221 0.4435 0.611
0.118118 1 1
0.0253 0.862 1
1.8787 1 1
0.0412 0.5852 0.5848
1.9998 1 1
0.3194 0.4141 0.4625
0.4082 1 1
0.0417 0.5095 0.5853
0.0851 1 1
0.0216 0.2921 0.2921
2.0486 0.5 0.5
0.1646 1 1
0.0506 0.4121 0.4121
0.3388 0.4325 0.7725
0.0253 0.5 0.5
1.6994 1 1
0.0669 1 1
0.0253 0.5 0.5
0.0506 0.5 0.5
0.206 1 1
0.0645 1 0.5
0.0253 0.5 0.5
0.1517 0.6967 0.6967
0.1328 1 1
0.0409 0.4981 1
0.1318 0.322 0.4629
1.9604 1 1
0.0223 0.3138 0.9209
0.041 0.55 0.548
1.6472 1 1
0.0506 0.5 0.5
0.1832 0.8702 1
0.1513 1 1
0.0506 1 1
0.1517 0.6967 0.6967
0.0296 0.3594 0.3843
0.0745 0.274 0.8382
0.1488 1 1
0.4939 1 1
0.0866 1 1
0.2849 1 1
0.1364 0.3491 0.3797
1.1937 1 1
0.1832 0.8702 1
0.1874 1 1
1.3986 1 1
0.786 1 1
0.0224 0.4285 0.4658
0.0253 1 1
0.416 1 1
1.4784 1 1
0.0253 0.5 0.5
0.0204 0.7041 1
0.0506 1 1
0.0253 0.5 0.5
0.7149 1 1
0.0928 1 1
0.2755 1 1
0.0314 0.6514 0.8688
0.0253 0.5 0.5
0.3413 1 1
0.0638 0.2559 0.472
0.0614 0.7317 0.7317
0.0506 0.4121 0.4121
0.3194 0.4141 0.4625
0.3158 0.4987 0.4987
0.0851 1 1
0.0928 1 1
0.1318 0.322 0.4629
0.0253 0.5 0.5
0.0253 1 1
0.243 1 1
0.5323 1 1
0.0506 1 1
0.0928 1 1
0.0253 0.5 0.5
0.0246 0.4096 0.7271
0.1832 0.8702 1
0.0233 0.4599 1
0.0659 1 0.5
0.0673 1 1
0.782 1 1
0.0915 0.5 0.5
0.0207 0.3826 0.655
0.0138 0.2546 0.5179
2.1396 1 1
0.0457 1 0.5
0.2204 1 1
0.3629 0.5 0.5
0.0226 0.2603 0.6799
0.1245 1 1
0.0226 0.3873 0.6168
0.0262 0.2833 0.2898
0.0419 0.5 0.5
0.0239 0.3616 0.7264
0.0138 0.6413 0.6413
0.3388 0.4325 0.7725
0.2469 1 1
1.7812 1 1
1.3114 1 1
0.0411 1 1
0.0442 1 0.5
1.503 1 1
0.7149 1 1
0.0419 0.5 0.5
0.0506 1 1
0.0466 0.7964 1
0.5711 1 1
0.0253 0.5 0.5
0.1318 0.322 0.4629
0.0425 0.2583 0.3949
0.0253 0.5 0.5
0.0205 0.8659 1
0.0413 0.5047 1
0.0506 0.9939 1
0.0477 0.2623 0.5234
0.7149 1 1
0.0631 0.2516 0.8913
0.043 0.5272 0.5272
0.2871 1 1
0.0506 0.2598 0.2598
0.7149 1 1
0.068 0.9906 0.9906
0.3388 0.4325 0.7725
1.4762 1 1
0.0932 0.9502 1
1.503 1 1
0.0854 1 1
0.0253 0.5 0.5
0.0253 0.5 0.5
0.1101 0.7096 0.7096
0.0253 0.4889 0.4889
0.0707 1 1
0.0728 1 1
0.0253 1 1
1.3166 1 1
0.4841 1 1
0.2671 1 1
1.8102 1 1
0.0208 1 1
0.0447 1 1
0.1318 0.322 0.4629
0.3901 1 1
0.0888 1 1
0.0457 0.2992 0.2935
1.8116 1 1
0.0483 0.705 0.705
0.0506 1 1
0.0253 0.5 0.5
0.2335 1 1
0.1318 0.322 0.4629
0.3413 1 1
0.0444 0.4395 1
1.5413 1 0.5
0.0441 1 1
0.1981 1 1
0.1254 0.3082 0.5514
2.1051 1 1
0.0456 0.2502 0.2866
0.0208 0.4525 0.4524
0.0968 0.988 1
1.7845 1 1
0.29 1 1
0.041 0.3691 0.3691
0.0506 0.5 0.5
0.0247 0.54 0.5
0.0658 1 0.5
0.0253 0.9591 1
0.0416 0.5028 1
0.0891 0.4126 1
0.0235 1 1
0.0506 1 1
0.0253 0.3094 0.7317
0.0506 0.5 0.5
1.0733 1 1
0.0224 0.4285 0.4658
1.8787 1 1
0.0206 1 1
1.1528 1 1
0.2601 0.2702 0.2702
0.0345 0.813 0.813
0.0414 0.5107 1
0.0253 0.8292 0.8292
1.4997 1 1
0.3387 1 1
1.7512 1 1
0.0425 1 1
0.0213 0.7911 0.7911
1.869 1 1
0.29 1 1
0.0464 0.4675 0.9382
0.2247 0.9132 1
0.696045 1 1
0.0253 0.5 0.5
0.0253 0.5 0.5
1.7785 1 1
0.1305 1 1
0.3812 1 1
0.1488 1 1
0.3388 0.4325 0.7725
0.4399 1 1
0.0423 0.5 0.5
0.3194 0.4141 0.4625
0.0484 1 1
0.0204 0.2691 0.2605
0.0253 0.5 0.5
0.0456 0.2502 0.2866
0.0215 0.4561 0.6005
0.0253 0.5 0.5
0.0481 1 1
0.0207 0.5 0.5
0.0285 0.2551 0.2533
0.0506 1 1
1.7882 1 1
0.2327 1 1
0.351 0.4505 0.4504
0.6134 0.5 0.5
1.6994 1 1
0.2239 1 1
0.0745 0.274 0.8382
1.9604 1 1
0.2544 1 1
0.3388 0.4325 0.7725
0.0209 0.6654 1
1.7517 1 1
0.1325 1 1
1.6092 1 1
1.4762 1 1
0.0506 1 1
0.0251 1 1
0.0628 0.791 1
1.8395 1 1
0.1321 1 1
0.0421 1 1
0.0204 0.8847 1
0.0506 0.7968 1
0.0183 0.4523 1
0.0253 0.5 0.5
0.0433 1 1
0.0635 1 1
0.3495 0.7606 0.7606
1.7374 1 1
0.0253 0.862 1
0.0337 0.2503 0.3017
0.1097 1 1
0.696045 1 1
0.264 1 1
0.0314 0.6514 0.8688
0.0413 0.5501 0.5602
0.0253 0.5 0.5
0.0221 0.4435 1
0.1616 1 1
0.0665 1 1
0.0678 1 1
1.5106 1 1
0.0246 0.299 0.6997
0.1328 1 1
0.351 0.4505 0.4504
0.0253 0.5 0.5
0.0506 0.8864 0.8864
0.1059 0.5 0.5
0.0381 0.3717 0.4067
0.0203 1 1
1.7374 1 1
0.0645 0.7059 0.9658
0.0506 1 1
0.3194 0.4141 0.4625
0.0649 1 1
0.0253 1 1
0.122 1 1
0.1318 0.322 0.4629
0.216 0.2955 0.2955
0.0506 1 1
0.0678 1 1
0.0435 0.4574 0.6135
0.0928 1 1
0.0253 1 1
0.1101 0.7096 0.7096
0.0253 0.5 0.5
0.3258 0.7606 0.7606
0.0253 0.3448 0.3347
0.4483 0.5 0.5
0.0462 1 0.5
0.1326 1 1
0.0419 0.5 0.5
0.129 0.5 0.5
1.9604 1 1

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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Gene identifier Smp_000130.3 (Schistosoma mansoni), hormone-sensitive lipase (S09 family)
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