Detailed view for Smp_159670

Basic information

TDR Targets ID: 292148
Schistosoma mansoni, synaptojanin
Source Database / ID:  GeneDB

pI: 7.0605 | Length (AA): 1117 | MW (Da): 126065 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF02383   SacI homology domain
PF03372   Endonuclease/Exonuclease/phosphatase family

Gene Ontology

Mouse over links to read term descriptions.
GO:0046856   phosphoinositide dephosphorylation  
GO:0042578   phosphoric ester hydrolase activity  
GO:0004437   inositol or phosphatidylinositol phosphatase activity  

Structural information

Modbase 3D models:

There are 6 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
2 335 3lwt (X) 124 456 29.00 0 1 0.485415 0.16
411 770 4cml (A) 259 564 42.00 0 1 0.652692 -0.48
413 822 5okm (A) 420 796 28.00 0 1 0.498555 -0.03
442 733 3n9v (A) 261 551 32.00 0.044 1 0.668914 -0.77
764 853 4ozd (A) 32 121 23.00 0.9 0.19 0.418973 -0.97
847 1117 4k6j (A) 857 1182 7.00 0 0.01 0.260114 -0.52

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_128608)

Species Accession Gene Product
Babesia bovis BBOV_IV011570   endonuclease/exonuclease/phosphatase family protein
Babesia bovis BBOV_IV011560   endonuclease/exonuclease/phosphatase family protein
Brugia malayi Bm1_02165   Endonuclease/Exonuclease/phosphatase family protein
Candida albicans CaO19.7052   inositol polyphosphate 5-phosphatase, Synaptojanin-like protein
Candida albicans CaO19_7052   hypothetical protein
Caenorhabditis elegans CELE_JC8.10   Protein UNC-26, isoform A
Cryptosporidium hominis Chro.20030   hypothetical protein
Cryptosporidium parvum cgd2_230   phosphatidylinositol phosphate phosphatase, putative
Dictyostelium discoideum DDB_G0292392   inositol 5-phosphatase
Drosophila melanogaster Dmel_CG6562   Synaptojanin
Echinococcus granulosus EgrG_001194200   synaptojanin 1
Echinococcus multilocularis EmuJ_001194200   synaptojanin 1
Homo sapiens ENSG00000159082   synaptojanin 1
Homo sapiens ENSG00000078269   synaptojanin 2
Loa Loa (eye worm) LOAG_05913   endonuclease/Exonuclease/phosphatase
Mus musculus ENSMUSG00000022973   synaptojanin 1
Mus musculus ENSMUSG00000023805   synaptojanin 2
Oryza sativa 4333650   Os03g0663700
Oryza sativa 4325335   Os01g0183300
Saccharomyces cerevisiae YNL106C   phosphatidylinositol-3-/phosphoinositide 5-phosphatase INP52
Saccharomyces cerevisiae YOR109W   phosphatidylinositol-3-/phosphoinositide 5-phosphatase INP53
Schistosoma japonicum Sjp_0013420   ko:K01099 phosphatidylinositol-bisphosphatase [EC3.1.3.36], putative
Schistosoma japonicum Sjp_0076620   expressed protein
Schistosoma mansoni Smp_159670   synaptojanin
Schmidtea mediterranea mk4.007358.00   Putative synaptojanin
Theileria parva TP01_1149   hypothetical protein

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Smp_159670 (Schistosoma mansoni), synaptojanin
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