Detailed view for Smp_000260

Basic information

TDR Targets ID: 292167
Schistosoma mansoni, saposin containing protein
Source Database / ID:  GeneDB

pI: 6.5116 | Length (AA): 927 | MW (Da): 104721 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF02199   Saposin A-type domain
PF03489   Saposin-like type B, region 2
PF05184   Saposin-like type B, region 1

Gene Ontology

Mouse over links to read term descriptions.
GO:0005764   lysosome  
GO:0006665   sphingolipid metabolic process  
GO:0006629   lipid metabolic process  

Metabolic Pathways

Lysosome (KEGG)

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
129 208 4uex (A) 0 80 34.00 0.02 1 0.6983 -1.98
133 207 5nxb (C) 4 79 37.00 0.000012 1 0.518206 -0.17
397 502 1qdm (A) 5 104 31.00 0.025 1 0.170647 -0.86
465 542 3bqp (A) 3 80 28.00 0 1 0.688942 -2.67

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_130508)

Species Accession Gene Product
Arabidopsis thaliana AT5G01800   saposin B domain-containing protein
Arabidopsis thaliana AT3G51730   saposin B domain-containing protein
Brugia malayi Bm1_37185   Saposin-like type B, region 1 family protein
Caenorhabditis elegans CELE_C28C12.7   Protein SPP-10, isoform A
Dictyostelium discoideum DDB_G0284339   saposin B domain-containing protein
Dictyostelium discoideum DDB_G0284043   saposin A
Dictyostelium discoideum DDB_G0286651   saposin B domain-containing protein
Drosophila melanogaster Dmel_CG12070   Saposin-related
Echinococcus granulosus EgrG_000733100   prosaposin a preproprotein
Echinococcus multilocularis EmuJ_000733100   prosaposin a preproprotein
Homo sapiens ENSG00000197746   prosaposin
Loa Loa (eye worm) LOAG_12164   hypothetical protein
Mus musculus ENSMUSG00000004207   prosaposin
Schistosoma japonicum Sjp_0216740   Proactivator polypeptide precursor [Contains: Saposin-A; Saposin-B; Saposin-C; Saposin-D], putative
Schistosoma japonicum Sjp_0116310   IPR008139,Saposin B;IPR011001,Saposin-like,domain-containing
Schistosoma mansoni Smp_000260   saposin containing protein
Schmidtea mediterranea mk4.011545.01  
Schmidtea mediterranea mk4.024461.00  
Schmidtea mediterranea mk4.011181.02  
Schmidtea mediterranea mk4.002629.00  
Schmidtea mediterranea mk4.002629.01  
Schmidtea mediterranea mk4.000676.00  
Schmidtea mediterranea mk4.011443.01  
Schmidtea mediterranea mk4.024461.01  
Schmidtea mediterranea mk4.000736.05   Saposin-related
Schmidtea mediterranea mk4.024589.01  
Schmidtea mediterranea mk4.024589.02  
Schmidtea mediterranea mk4.011181.00  
Schmidtea mediterranea mk4.004960.00  
Schmidtea mediterranea mk4.011545.00  
Trichomonas vaginalis TVAG_000220   saposin, putative
Trichomonas vaginalis TVAG_388060   saposin, putative
Trichomonas vaginalis TVAG_473630   saposin, putative

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Smp_000260 (Schistosoma mansoni), saposin containing protein
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