Detailed view for Smp_170750

Basic information

TDR Targets ID: 292508
Schistosoma mansoni, paired box protein pax-6
Source Database / ID:  GeneDB

pI: 7.3282 | Length (AA): 712 | MW (Da): 81819 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00046   Homeobox domain
PF00292   'Paired box' domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0006355   regulation of transcription, DNA-dependent  
GO:0005634   nucleus  
GO:0003700   transcription factor activity  
GO:0003677   DNA binding  
GO:0043565   sequence-specific DNA binding  
GO:0045449   regulation of transcription  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1 158 2k27 (A) 1 159 58.00 0.00000046 1 0.76161 0.86
9 139 6pax (A) 2 132 85.00 0 1 1.22149 -0.97
317 363 3cmy (A) 14 59 59.00 0.0000000021 0.77 0.886511 -1.83
318 366 2cue (A) 20 68 67.00 0.0000000000069 0.73 0.93732 -1.35

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_131571)

Species Accession Gene Product
Brugia malayi Bm1_37835   vab-3 gene.
Caenorhabditis elegans CELE_F14F3.1   Protein VAB-3, isoform C
Drosophila melanogaster Dmel_CG1464   eyeless
Drosophila melanogaster Dmel_CG11186   twin of eyeless
Echinococcus granulosus EgrG_000781700   paired box gene 3/7 (eyeless, eyegone, twin of eyeless)
Echinococcus granulosus EgrG_000389800   paired box protein pax 6
Echinococcus multilocularis EmuJ_000781700   paired box protein pax 6
Echinococcus multilocularis EmuJ_000389800   paired box protein pax 6
Homo sapiens ENSG00000007372   paired box 6
Loa Loa (eye worm) LOAG_04187   vab-3
Mus musculus ENSMUSG00000027168   paired box 6
Onchocerca volvulus OVOC4321   Retinal homeobox protein Rx homolog
Schistosoma japonicum Sjp_0004220   ko:K08031 paired box protein 6, putative
Schistosoma mansoni Smp_170750   paired box protein pax-6
Schmidtea mediterranea mk4.002519.00   Pax6A
Schmidtea mediterranea mk4.001769.00   Paired box protein Pax-6

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Smp_170750 (Schistosoma mansoni), paired box protein pax-6
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