Detailed view for Smp_160310

Basic information

TDR Targets ID: 293074
Schistosoma mansoni, lysosomal alpha-mannosidase (mannosidase alpha class 2b member 1), putative

Source Database / ID: SchistoDB.net / Smp_160310  GeneDB / Smp_160310

pI: 6.4828 | Length (AA): 768 | MW (Da): 89209 | Number of Paralogs: 2

EC number(s): No EC number(s) registered for this gene.

Signal peptide: N | GPI Anchor: N (Show evidence) | Predicted trans-membrane segments: ND

Pfam domains

PF07748   Glyco_hydro_38C
PF09261   Alpha-mann_mid

Gene Ontology

Function: (mouse over links to read term descriptions)

GO:0003824   catalytic activity  
GO:0030246   carbohydrate binding  
GO:0015923   mannosidase activity  
GO:0008270   zinc ion binding  
GO:0004559   alpha-mannosidase activity  

Process: (mouse over links to read term descriptions)

GO:0006013   mannose metabolic process  
GO:0005975   carbohydrate metabolic process  
Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Functional classes

No functional classes assigned to this gene.

Structural information

Modbase 3D models: Smp_160310  

PDB structures: no structure available for this protein in the PDB.

Expression

No expression information available for this gene.

Antigenicity

Number of putative antigenic epitopes: 33
Cumulative epitope score: 37.0
Normalized epitope score: 4.8
Percentile: 68.6 (this protein belongs to the top 31.4% proteins in the genome of Schistosoma mansoni, based on the predicted antigenicity).

[+/–]   More information on this prediction ...

Orthologs

OrthoMCL 4 cluster: OG4_72356
Number of Paralogs: 2

Ortholog group members from selected species:
Schistosoma mansoni Smp_160310 (this record).   lysosomal alpha-mannosidase (mannosidase alpha class 2b memb... |   OrthoMCL
Schistosoma mansoni Smp_119180   lysosomal alpha-mannosidase (mannosidase alpha class 2b memb... |   OrthoMCL

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

Associated compounds / Druggability
  • Curated from literature

    No chemical compounds is associated to this gene

  • Predicted associations

    • By orthology to known druggable targets

    • No orthologous druggable targets
    • By sequence similarity to non orthologous druggable targets

    • No additional associated druggable targets
  • Assayability

    Assay information

    No assay information for this target.

    Reagent availability

    No reagent availability information for this target.

    Bibliographic references

    No literature references are available for this gene.

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    User comments

    No user comments are available for this gene.

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