Detailed view for LmjF.01.0820

Basic information

TDR Targets ID: 29328
Leishmania major, potassium channel subunit-like protein
Source Database / ID:  TriTrypDB  GeneDB

pI: 5.7141 | Length (AA): 1159 | MW (Da): 126734 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 5

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF07885   Ion channel

Gene Ontology

Mouse over links to read term descriptions.
GO:0016020   membrane  
GO:0005267   potassium channel activity  
GO:0003824   catalytic activity  
GO:0015269   calcium-activated potassium channel activity  
GO:0005488   binding  
GO:0008152   metabolic process  
GO:0006813   potassium ion transport  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 12 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
19 115 1s1g (A) 39 142 19.00 0.0000000000016 0.11 0.24 -0.73
250 350 2ahy (A) 1 95 15.00 0.000059 0.02 0.25 -0.76
278 365 1r3j (C) 35 122 18.00 0.00009 0.03 0.41 -1.63
614 739 1lss (A) 1 124 6.00 0.0000000031 0.03 0.19 -0.42
2 85 3kvt (A) 23 104 9.00 0.012 0.01 0.0739763 0.56
272 356 3ldc (A) 18 97 19.00 0 0.08 0.188339 -0.08
282 354 2a9h (A) 35 111 26.00 0.5 0.33 0.264585 0.32
307 345 3ouf (A) 52 92 36.00 0.17 0.16 0.18125 1.69
602 821 5cwp (A) 11 227 11.00 0.42 0.06 0.286319 -0.04
688 770 4ke2 (A) 106 185 38.00 0.014 0.03 0.335213 0.8
871 1154 3naf (A) 698 1052 19.00 0 1 0.273039 0.63
883 1042 5but (A) 126 271 11.00 0.026 0.16 0.06155 -0.01

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Lower 0-20% percentile amastigotes, metacyclic. Fernandes MC
Show/Hide expression data references
  • Fernandes MC Dual Transcriptome Profiling of Leishmania-Infected Human Macrophages Reveals Distinct Reprogramming Signatures.

Orthologs

Ortholog group members (OG5_171427)

Species Accession Gene Product
Leishmania braziliensis LbrM.01.0780   potassium channel subunit-like protein
Leishmania donovani LdBPK_010840.1   potassium channel subunit-like protein
Leishmania infantum LinJ.01.0840   potassium channel subunit-like protein
Leishmania major LmjF.01.0820   potassium channel subunit-like protein
Leishmania mexicana LmxM.01.0820  
Schistosoma japonicum Sjp_0057390   Calcium-activated potassium channel slowpoke, putative
Schistosoma mansoni Smp_008170   calcium-activated potassium channel

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Druggability index (range: 0 to 1): 0.7

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier LmjF.01.0820 (Leishmania major), potassium channel subunit-like protein
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