Detailed view for Smp_000320

Basic information

TDR Targets ID: 293892
Schistosoma mansoni, Ndr family
Source Database / ID:  GeneDB

pI: 8.8326 | Length (AA): 219 | MW (Da): 24765 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 1

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF03096   Ndr family

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_137759)

Species Accession Gene Product
Brugia malayi Bm1_40645   Hypothetical 35.6 kDa protein ZK1073.1 in chromosome X, putative
Caenorhabditis elegans CELE_ZK1073.1   Protein ZK1073.1
Drosophila melanogaster Dmel_CG2082   CG2082 gene product from transcript CG2082-RO
Echinococcus granulosus EgrG_000947700   hypothetical protein
Echinococcus granulosus EgrG_001065500   Ndr
Echinococcus multilocularis EmuJ_000948500   Ndr
Echinococcus multilocularis EmuJ_000948600   Ndr
Echinococcus multilocularis EmuJ_000948000   Ndr family protein
Echinococcus multilocularis EmuJ_001065500   Ndr
Echinococcus multilocularis EmuJ_000948100   Ndr
Echinococcus multilocularis EmuJ_000947700   Ndr
Loa Loa (eye worm) LOAG_06299   hypothetical protein
Schistosoma japonicum Sjp_0086390   IPR004142,Ndr,domain-containing
Schistosoma japonicum Sjp_0024830   IPR004142,Ndr,domain-containing
Schistosoma japonicum Sjp_0303030   Protein NDRG4, putative
Schistosoma mansoni Smp_000320   Ndr family
Schistosoma mansoni Smp_194720   family S33 non-peptidase homologue (S33 family)
Schmidtea mediterranea mk4.014264.01  
Schmidtea mediterranea mk4.005729.04   Family S33 non-peptidase homologue
Schmidtea mediterranea mk4.019412.01   BcDNA.GH02439
Schmidtea mediterranea mk4.005770.01  
Schmidtea mediterranea mk4.001370.06  

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Smp_000320 (Schistosoma mansoni), Ndr family
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