Detailed view for TcCLB.507669.190

Basic information

TDR Targets ID: 30011
Trypanosoma cruzi, Calmodulin-binding, putative
Source Database / ID:  TriTrypDB  GeneDB

pI: 9.5936 | Length (AA): 274 | MW (Da): 30361 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF13864   Calmodulin-binding

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 2 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
165 266 3lg7 (A) 10 116 12.00 0.078 0.13 0.613063 -1.36
177 269 3v6i (B) 23 114 28.00 0.031 0.07 0.609216 0.02

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile epimastigote, metacyclic. Smircich P
Show/Hide expression data references
  • Smircich P Ribosome profiling reveals translation control as a key mechanism generating differential gene expression in Trypanosoma cruzi.

Orthologs

Ortholog group members (OG5_130018)

Species Accession Gene Product
Drosophila melanogaster Dmel_CG16984   CG16984 gene product from transcript CG16984-RA
Echinococcus granulosus EgrG_000361400   enkurin TRPC channel interacting protein
Echinococcus granulosus EgrG_000586400   enkurin
Echinococcus multilocularis EmuJ_000361400   enkurin, TRPC channel interacting protein
Echinococcus multilocularis EmuJ_000586400   enkurin
Giardia lamblia GL50803_16996   Hypothetical protein
Homo sapiens ENSG00000151023   enkurin, TRPC channel interacting protein
Leishmania braziliensis LbrM.24.0100   hypothetical protein, conserved
Leishmania donovani LdBPK_240100.1   Calmodulin-binding, putative
Leishmania infantum LinJ.24.0100   hypothetical protein, conserved
Leishmania major LmjF.24.0100   hypothetical protein, conserved
Leishmania mexicana LmxM.24.0100   hypothetical protein, conserved
Mus musculus ENSMUSG00000026679   enkurin, TRPC channel interacting protein
Neospora caninum NCLIV_002740   Related to CG16984 PROTEIN, related
Plasmodium berghei PBANKA_1330000   conserved Plasmodium protein, unknown function
Plasmodium falciparum PF3D7_1466600   conserved Plasmodium protein, unknown function
Plasmodium knowlesi PKNH_1214900   conserved Plasmodium protein, unknown function
Plasmodium vivax PVX_117135   hypothetical protein, conserved
Plasmodium yoelii PY06249   related to CG16984 PROTEIN
Schistosoma japonicum Sjp_0204970   Enkurin, putative
Schistosoma mansoni Smp_048690   hypothetical protein
Schmidtea mediterranea mk4.003939.04   Enkurin
Schmidtea mediterranea mk4.002841.04   Enkurin
Trypanosoma brucei gambiense Tbg972.11.5500   hypothetical protein, conserved
Trypanosoma brucei Tb927.11.4880   Calmodulin-binding, putative
Trypanosoma congolense TcIL3000.11.4910   hypothetical protein, conserved
Trypanosoma cruzi TcCLB.507669.190   Calmodulin-binding, putative
Trypanosoma cruzi TcCLB.509877.10   Calmodulin-binding, putative
Toxoplasma gondii TGME49_207790   enkurin, putative
Trichomonas vaginalis TVAG_451210   Enkurin, putative
Trichomonas vaginalis TVAG_061940   Enkurin, putative
Trichomonas vaginalis TVAG_227090   Enkurin, putative
Trichomonas vaginalis TVAG_470730   Enkurin, putative

Essentiality

TcCLB.507669.190 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb11.02.2490 Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb11.02.2490 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb11.02.2490 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb11.02.2490 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
TGME49_207790 Toxoplasma gondii Probably non-essential sidik
Show/Hide essentiality data references
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier TcCLB.507669.190 (Trypanosoma cruzi), Calmodulin-binding, putative
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