Detailed view for TcCLB.511139.20

Basic information

TDR Targets ID: 30139
Trypanosoma cruzi, 40S ribosomal protein S11, putative
Source Database / ID:  TriTrypDB  GeneDB

pI: 11.0557 | Length (AA): 173 | MW (Da): 19957 | Paralog Number: 3

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00366   Ribosomal protein S17
PF16205   Ribosomal_S17 N-terminal

Gene Ontology

Mouse over links to read term descriptions.
GO:0005840   ribosome  
GO:0005622   intracellular  
GO:0003735   structural constituent of ribosome  
GO:0006412   translation  

Metabolic Pathways

Ribosome (KEGG)

Structural information

Modbase 3D models:

There are 2 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
84 161 2avy (Q) 5 81 39.00 0.0000024 0.97 0.82 0.42
16 170 4kzy (L) 3 158 57.00 0 1 1.50825 0.47

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile epimastigote, metacyclic. Smircich P
Show/Hide expression data references
  • Smircich P Ribosome profiling reveals translation control as a key mechanism generating differential gene expression in Trypanosoma cruzi.

Orthologs

Ortholog group members (OG5_126986)

Species Accession Gene Product
Arabidopsis thaliana AT5G23740   40S ribosomal protein S11-3
Arabidopsis thaliana AT4G30800   40S ribosomal protein S11-2
Arabidopsis thaliana AT3G48930   40S ribosomal protein S11-1
Babesia bovis BBOV_II004570   40S ribosomal protein S11, putative
Brugia malayi Bm1_33760   40S ribosomal protein S11
Caenorhabditis elegans CELE_F40F11.1   Protein RPS-11
Dictyostelium discoideum DDB_G0282601   40S ribosomal protein S11
Drosophila melanogaster Dmel_CG8857   Ribosomal protein S11
Echinococcus granulosus EgrG_000861700   40S ribosomal protein S11
Entamoeba histolytica EHI_124850   40S ribosomal protein S11, putative
Entamoeba histolytica EHI_155410   40S ribosomal protein S11, putative
Echinococcus multilocularis EmuJ_000861700   40S ribosomal protein S11
Giardia lamblia GL50803_14827   Ribosomal protein S11
Homo sapiens ENSG00000142534   ribosomal protein S11
Leishmania braziliensis LbrM.20.5810   ribosomal protein S11 homolog
Leishmania braziliensis LbrM.21.1680   40S ribosomal protein S11, putative
Leishmania infantum LinJ.21.1790   40S ribosomal protein S11, putative
Leishmania infantum LinJ.20.1620   ribosomal protein S11 homolog
Leishmania major LmjF.20.1650   ribosomal protein S11 homolog
Leishmania major LmjF.21.1550   40S ribosomal protein S11, putative
Leishmania mexicana LmxM.21.1550   40S ribosomal protein S11, putative
Leishmania mexicana LmxM.20.1650   ribosomal protein S11 homolog
Loa Loa (eye worm) LOAG_12512   40S ribosomal protein S11
Mus musculus 674896   predicted gene, 29690
Mus musculus 102642908   40S ribosomal protein S11-like
Mus musculus ENSMUSG00000003429   ribosomal protein S11
Neospora caninum NCLIV_046040   hypothetical protein
Oryza sativa 4343620   Os07g0565000
Oryza sativa 4336976   Os04g0613600
Oryza sativa 4336317   Os04g0502300
Oryza sativa 4336975   Os04g0613500
Oryza sativa 9271697   Os07g0565101
Oryza sativa 4344935   Os08g0207000
Plasmodium berghei PBANKA_0807600   40S ribosomal protein S11, putative
Plasmodium falciparum PF3D7_0317600   40S ribosomal protein S11, putative
Plasmodium knowlesi PKNH_0824200   40S ribosomal protein S11, putative
Plasmodium vivax PVX_095350   40S ribosomal protein S11, putative
Plasmodium yoelii PY06696   ribosomal protein S17, putative
Saccharomyces cerevisiae YBR048W   ribosomal 40S subunit protein S11B
Saccharomyces cerevisiae YDR025W   ribosomal 40S subunit protein S11A
Schistosoma japonicum Sjp_0059680   ko:K02949 small subunit ribosomal protein S11e, putative
Schistosoma mansoni Smp_032760   ribosomal protein S11
Schmidtea mediterranea mk4.003243.00   40S ribosomal protein S11
Trypanosoma brucei gambiense Tbg972.1.1940   40S ribosomal protein S11, putative
Trypanosoma brucei gambiense Tbg972.10.540   40S ribosomal proteins S11, putative
Trypanosoma brucei Tb927.1.3180   40S ribosomal protein S11, putative
Trypanosoma brucei Tb927.10.560   40S ribosomal proteins S11, putative
Trypanosoma congolense TcIL3000_10_420   40S ribosomal proteins S11, putative
Trypanosoma congolense TcIL3000_1_1540   40S ribosomal proteins S11, putative
Trypanosoma cruzi TcCLB.507837.50   40S ribosomal protein S11, putative
Trypanosoma cruzi TcCLB.508405.40   40S ribosomal protein S11, putative
Trypanosoma cruzi TcCLB.508319.70   40S ribosomal protein S11, putative
Trypanosoma cruzi TcCLB.511139.20   40S ribosomal protein S11, putative
Toxoplasma gondii TGME49_226970   ribosomal protein RPS11
Theileria parva TP02_0298   40S ribosomal protein S11, putative
Trichomonas vaginalis TVAG_099560   30S ribosomal protein S17, putative
Trichomonas vaginalis TVAG_131850   40S ribosomal protein S11, putative
Trichomonas vaginalis TVAG_419520   30S ribosomal protein S17p, putative
Trichomonas vaginalis TVAG_401900   30S ribosomal protein S17p, putative
Trichomonas vaginalis TVAG_113950   40S ribosomal protein S11, putative
Trichomonas vaginalis TVAG_313300   40S ribosomal protein S11, putative

Essentiality

TcCLB.511139.20 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.10.560 Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb927.10.560 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb927.10.560 Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb927.10.560 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
Tb927.1.3180 Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb927.1.3180 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb927.1.3180 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.1.3180 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_F40F11.1 Caenorhabditis elegans embryonic lethal wormbase
CELE_F40F11.1 Caenorhabditis elegans larval arrest wormbase
CELE_F40F11.1 Caenorhabditis elegans sterile wormbase
TGME49_226970 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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Gene identifier TcCLB.511139.20 (Trypanosoma cruzi), 40S ribosomal protein S11, putative
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