Detailed view for TcCLB.507927.60

Basic information

TDR Targets ID: 30383
Trypanosoma cruzi, DJ-1 family protein, putative
Source Database / ID:  TriTrypDB  GeneDB

pI: 7.2426 | Length (AA): 198 | MW (Da): 21204 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG3

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF01965   DJ-1/PfpI family

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
2 186 2rk3 (A) 3 188 37.00 0 1 1.48784 -1.28
2 198 3ot1 (A) 6 200 36.00 0 1 1.48205 -1.14
4 170 1g2i (A) 2 165 27.00 0 1 1.27393 -0.96

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile epimastigote, metacyclic. Smircich P
Show/Hide expression data references
  • Smircich P Ribosome profiling reveals translation control as a key mechanism generating differential gene expression in Trypanosoma cruzi.

Orthologs

Ortholog group members (OG5_127669)

Species Accession Gene Product
Arabidopsis thaliana AT3G14990   protein DJ-1-like A
Arabidopsis thaliana AT1G53280   DJ1-like protein B
Babesia bovis BBOV_I002290   4-methyl-5(B-hydroxyethyl)-thiazol monophosphate biosynthesis enzyme, putative
Brugia malayi Bm1_07685   DJ-1 family protein
Caenorhabditis elegans CELE_B0432.2   Protein DJR-1.1
Caenorhabditis elegans CELE_C49G7.11   Protein DJR-1.2
Cryptosporidium hominis Chro.50218   CG1349 gene product
Cryptosporidium parvum cgd5_1650   hypothetical protein
Dictyostelium discoideum DDB_G0286443   hypothetical protein
Drosophila melanogaster Dmel_CG6646   CG6646 gene product from transcript CG6646-RA
Drosophila melanogaster Dmel_CG1349   CG1349 gene product from transcript CG1349-RA
Escherichia coli b0424   oxidative-stress-resistance chaperone
Echinococcus granulosus EgrG_000135900   protein DJ 1
Entamoeba histolytica EHI_027600   4-methyl-5(B-hydroxyethyl)-thiazol monophosphate biosynthesis enzyme, putative
Echinococcus multilocularis EmuJ_000135900   protein DJ 1
Giardia lamblia GL50803_9088   4-methyl-5-thiazole monophosphate biosynthesis enzyme
Homo sapiens ENSG00000116288   parkinson protein 7
Leishmania braziliensis LbrM.30.0870   4-methyl-5(beta-hydroxyethyl)-thiazole monophosphate synthesis protein, putative
Leishmania donovani LdBPK_300800.1   4-methyl-5(beta-hydroxyethyl)-thiazole monophosphate synthesis protein, putative
Leishmania infantum LinJ.30.0800   4-methyl-5(beta-hydroxyethyl)-thiazole monophosphate synthesis protein, putative
Leishmania major LmjF.30.0750   4-methyl-5(beta-hydroxyethyl)-thiazole monophosphate synthesis protein, putative
Leishmania mexicana LmxM.29.0750   4-methyl-5(beta-hydroxyethyl)-thiazole monophosphate synthesis protein, putative
Loa Loa (eye worm) LOAG_06487   DJ-1 family protein
Mus musculus ENSMUSG00000028964   Parkinson disease (autosomal recessive, early onset) 7
Neospora caninum NCLIV_051530   hypothetical protein
Oryza sativa 4324581   Os01g0217800
Oryza sativa 4341205   Os06g0531200
Plasmodium berghei PBANKA_1126200   protein DJ-1, putative
Plasmodium falciparum PF3D7_0627500   protein DJ-1
Plasmodium knowlesi PKNH_1122300   protein DJ-1, putative
Plasmodium vivax PVX_114480   protein DJ-1, putative
Plasmodium yoelii PY04638   Drosophila melanogaster CG1349 gene product
Schistosoma japonicum Sjp_0008070   ko:K05687 protein DJ-1, putative
Schistosoma mansoni Smp_082030   family C56 non-peptidase homologue (C56 family)
Schmidtea mediterranea mk4.000453.00   Protein DJ-1
Schmidtea mediterranea mk4.000453.01   Protein DJ-1
Trypanosoma brucei gambiense Tbg972.6.1980   hypothetical protein, conserved
Trypanosoma brucei Tb927.6.2200   DJ-1 family protein, putative
Trypanosoma congolense TcIL3000_6_1810   hypothetical protein, conserved
Trypanosoma cruzi TcCLB.509047.40   DJ-1 family protein, putative
Trypanosoma cruzi TcCLB.507927.60   DJ-1 family protein, putative
Toxoplasma gondii TGME49_214290   DJ-1 family protein
Treponema pallidum TP0445   4-methyl-5(b-hydroxyethyl)-thiazole monophosphate biosynthesis enzyme (thiJ)
Theileria parva TP03_0100   4-methyl-5(b-hydroxyethyl)-thiazole monophosphate biosynthesis protein, putative
Trichomonas vaginalis TVAG_420420   dj-1 protein, putative
Trichomonas vaginalis TVAG_240750   4-methyl-5(B-hydroxyethyl)-thiazole monophosphate biosynthesis enzyme, putative
Trichomonas vaginalis TVAG_302880   thij/pfpi, putative

Essentiality

TcCLB.507927.60 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.6.2200 Trypanosoma brucei significant gain of fitness in bloodstream forms (3 days) alsford
Tb927.6.2200 Trypanosoma brucei significant gain of fitness in bloodstream forms (6 days) alsford
Tb927.6.2200 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.6.2200 Trypanosoma brucei significant gain of fitness in differentiation of procyclic to bloodstream forms alsford
b0424 Escherichia coli non-essential goodall
PBANKA_1126200 Plasmodium berghei Dispensable plasmo
TGME49_214290 Toxoplasma gondii Probably non-essential sidik
Show/Hide essentiality data references
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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Gene identifier TcCLB.507927.60 (Trypanosoma cruzi), DJ-1 family protein, putative
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