Detailed view for TcCLB.511211.120

Basic information

TDR Targets ID: 30794
Trypanosoma cruzi, receptor for activated C kinase 1, putative
Source Database / ID:  TriTrypDB  GeneDB

pI: 6.0313 | Length (AA): 318 | MW (Da): 35031 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00400   WD domain, G-beta repeat

Gene Ontology

Mouse over links to read term descriptions.
GO:0005515   protein binding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 2 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
3 315 4aow (A) 5 313 55.00 0 1 1.70448 -1.25
3 315 3frx (A) 7 316 38.00 0 1 1.47408 -0.64

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

PDB tag
  • 5OPT:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile epimastigote, metacyclic. Smircich P
Show/Hide expression data references
  • Smircich P Ribosome profiling reveals translation control as a key mechanism generating differential gene expression in Trypanosoma cruzi.

Orthologs

Ortholog group members (OG5_127516)

Species Accession Gene Product
Arabidopsis thaliana AT3G18130   receptor for activated C kinase 1C
Arabidopsis thaliana AT1G18080   guanine nucleotide-binding protein subunit beta-like protein A
Arabidopsis thaliana AT1G48630   receptor for activated C kinase 1B
Babesia bovis BBOV_II003050   receptor for activated C kinase, RACK protein
Brugia malayi Bm1_36465   activated protein kinase C receptor RACK1 - rat, putative
Candida albicans CaO19_6906   hypothetical protein
Candida albicans CaO19.6906   G-beta-like protein
Caenorhabditis elegans CELE_K04D7.1   Protein RACK-1
Cryptosporidium hominis Chro.20203   guanine nucleotide-binding protein
Cryptosporidium parvum cgd2_1870   guanine nucleotide-binding protein, putative
Dictyostelium discoideum DDB_G0275045   hypothetical protein
Drosophila melanogaster Dmel_CG7111   Receptor of activated protein kinase C 1
Echinococcus granulosus EgrG_001132500   guanine nucleotide binding protein subunit
Entamoeba histolytica EHI_050550   guanine nucleotide-binding protein subunit beta 2-like 1, putative
Entamoeba histolytica EHI_110400   guanine nucleotide-binding protein subunit beta 2-like 1, putative
Entamoeba histolytica EHI_171280   guanine nucleotide-binding protein subunit beta 2-like 1, putative
Echinococcus multilocularis EmuJ_001132500   guanine nucleotide binding protein subunit
Homo sapiens ENSG00000204628   guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1
Leishmania braziliensis LbrM.28.2950   activated protein kinase c receptor (LACK),guanine nucleotide-binding protein beta subunit- like protein
Leishmania donovani LdBPK_282970.1   activated protein kinase c receptor (LACK)
Leishmania infantum LinJ.28.2970   activated protein kinase c receptor (LACK)
Leishmania infantum LinJ.28.2940   activated protein kinase c receptor (LACK)
Leishmania major LmjF.28.2750   activated protein kinase c receptor (LACK),guanine nucleotide-binding protein beta subunit- like protein
Leishmania major LmjF.28.2740   activated protein kinase c receptor (LACK),guanine nucleotide-binding protein beta subunit- like protein
Leishmania mexicana LmxM.28.2740   activated protein kinase c receptor (LACK),guanine nucleotide-binding protein beta subunit- like protein
Leishmania mexicana LmxM.28.2740a  
Loa Loa (eye worm) LOAG_04975   activated protein kinase C receptor RACK1
Mus musculus ENSMUSG00000020372   guanine nucleotide binding protein (G protein), beta polypeptide 2 like 1
Neospora caninum NCLIV_059430   hypothetical protein
Oryza sativa 4324115   Os01g0686800
Oryza sativa 4339539   Os05g0552300
Plasmodium berghei PBANKA_0703900   receptor for activated c kinase, putative
Plasmodium falciparum PF3D7_0826700   receptor for activated c kinase
Plasmodium knowlesi PKNH_1320900   receptor for activated c kinase, putative
Plasmodium vivax PVX_089025   receptor for activated c kinase, putative
Plasmodium yoelii PY00516   hypothetical protein
Saccharomyces cerevisiae YMR116C   guanine nucleotide-binding protein subunit beta
Schistosoma japonicum Sjp_0015980   ko:K00567 methylated-DNA-[protein]-cysteine S-methyltransferase [EC2.1.1.63], putative
Schistosoma mansoni Smp_102040.3   receptor for activated PKC
Schistosoma mansoni Smp_102040.1   receptor for activated PKC
Schistosoma mansoni Smp_102040.2   receptor for activated PKC
Schmidtea mediterranea mk4.000213.11   Guanine nucleotide-binding protein subunit beta-2-like 1
Trypanosoma brucei gambiense Tbg972.11.12690   guanine nucleotide-binding protein beta subunit-like protein,activated protein kinase c receptor
Trypanosoma brucei Tb927.11.11370   receptor for activated C kinase 1
Trypanosoma brucei Tb927.11.11360   receptor for activated C kinase 1
Trypanosoma congolense TcIL3000.11.12030   receptor for activated C kinase 1
Trypanosoma cruzi TcCLB.511211.120   receptor for activated C kinase 1, putative
Trypanosoma cruzi TcCLB.511211.130   receptor for activated C kinase 1, putative
Toxoplasma gondii TGME49_216880   guanine nucleotide-binding protein
Theileria parva TP04_0288   guanine nucleotide-binding protein, putative
Trichomonas vaginalis TVAG_429360   WD repeat domain, putative
Trichomonas vaginalis TVAG_145570   receptor for activated protein kinase C, putative
Trichomonas vaginalis TVAG_151920   WD repeat domain, putative

Essentiality

TcCLB.511211.120 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb11.01.3170 Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb11.01.3170 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb11.01.3170 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb11.01.3170 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_K04D7.1 Caenorhabditis elegans embryonic lethal wormbase
CELE_K04D7.1 Caenorhabditis elegans larval lethal wormbase
CELE_K04D7.1 Caenorhabditis elegans slow growth wormbase
CELE_K04D7.1 Caenorhabditis elegans sterile wormbase
TGME49_216880 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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User comments

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Gene identifier TcCLB.511211.120 (Trypanosoma cruzi), receptor for activated C kinase 1, putative
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