Detailed view for PF3D7_0102200

Basic information

TDR Targets ID: 3144
Plasmodium falciparum, ring-infected erythrocyte surface antigen

Source Database / ID: PlasmoDB / PF3D7_0102200  GeneDB / PF3D7_0102200

pI: 4.1273 | Length (AA): 1085 | MW (Da): 126521 | Paralog Number: 6

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: ND

Pfam domains

PF00226   DnaJ domain
PF09687   Plasmodium RESA N-terminal
PF14308   X-domain of DnaJ-containing

Gene Ontology

Mouse over links to read term descriptions.
GO:0020002   host cell plasma membrane  
GO:0031072   heat shock protein binding  

Network

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models: 2

There are 2 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
517 593 2ctp (A) 2 78 25.00 0 1 0.42 -1.61
524 590 2ctr (A) 9 75 34.00 0.00000001 1 0.69 -2.22

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Shows this level of upregulation in
This gene ranks in the upper 80-100% group of genes. merozoite, sporozoite, early ring, early schizont, early trophozoite, late ring, late schizont.
Upregulation Percent Ranking Shows this level of upregulation in
This gene ranks in the mid 40-60% group of genes. gametocyte, late trophozoite.
Show/Hide expression data references
  • PlasmoDB Data on upregulation of P. falciparum genes in different life cycle stages, combined from several microarray experiments available in PlasmoDB

Orthologs

Ortholog group members (OG5_146472)
Species Accession Gene Product
Plasmodium falciparum PF3D7_0102200 this record   ring-infected erythrocyte surface antigen
Plasmodium falciparum PF3D7_0220100   DnaJ protein, putative
Plasmodium falciparum PF3D7_1038800   RESA-like protein with PHIST and DnaJ domains
Plasmodium falciparum PF3D7_0831200   DnaJ protein, putative
Plasmodium falciparum PF3D7_1149200   ring-infected erythrocyte surface antigen
Plasmodium falciparum PF3D7_1201100   RESA-like protein with PHIST and DnaJ domains
Plasmodium falciparum PF3D7_0201700   DnaJ protein, putative

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Curated from literature

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

No user comments are available for this gene. Log in to add comments, or register.

Enter your comment

User ()
Gene identifier PF3D7_0102200 (Plasmodium falciparum), ring-infected erythrocyte surface antigen
Title for this comment
Comment

© 2013 – 2018 Trypanosomatics Lab | IIBIO - UNSAM
© 2005 – 2012 The TDR Drug Targets Network (WHO/TDR)

TDR Targets Development Release v6, Revision: 1335 (10.Aug.2018)
Contact Us: <info at tdrtargets org>