Detailed view for PF3D7_0103000

Basic information

TDR Targets ID: 3152
Plasmodium falciparum, vacuolar protein sorting-associated protein VTA1, putative

Source Database / ID: PlasmoDB / PF3D7_0103000  GeneDB / PF3D7_0103000

pI: 4.8065 | Length (AA): 259 | MW (Da): 30260 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: ND

Pfam domains

PF04652   Vta1 like

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Network

Metabolic Pathways

Endocytosis (KEGG)

Structural information

Modbase 3D models: 0

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Shows this level of upregulation in
This gene ranks in the mid 40-60% group of genes. early schizont.
Show/Hide expression data references
  • PlasmoDB Data on upregulation of P. falciparum genes in different life cycle stages, combined from several microarray experiments available in PlasmoDB

Orthologs

Ortholog group members (OG5_129256)
Species Accession Gene Product
Arabidopsis thaliana AT4G26750   LYST INTERACTING PROTEIN 5
Brugia malayi Bm1_35735   RhoGAP domain containing protein
Caenorhabditis elegans CELE_T23G11.7   Protein T23G11.7, isoform A
Dictyostelium discoideum DDB_G0271488   hypothetical protein
Drosophila melanogaster Dmel_CG7967   CG7967 gene product from transcript CG7967-RA
Echinococcus granulosus EgrG_000675600   protein of unknown function DUF605
Echinococcus multilocularis EmuJ_000675600   protein of unknown function DUF605
Homo sapiens ENSG00000009844   vesicle (multivesicular body) trafficking 1
Leishmania braziliensis LbrM.05.0720   hypothetical protein, conserved
Leishmania donovani LdBPK_050740.1   Vta1 like, putative
Leishmania infantum LinJ.05.0740   hypothetical protein, conserved
Leishmania major LmjF.05.0740   hypothetical protein, conserved
Leishmania mexicana LmxM.05.0740   hypothetical protein, conserved
Loa Loa (eye worm) LOAG_00344   hypothetical protein
Loa Loa (eye worm) LOAG_00343   hypothetical protein
Mus musculus ENSMUSG00000019868   Vps20-associated 1 homolog (S. cerevisiae)
Oryza sativa 4340850   Os06g0308800
Plasmodium berghei PBANKA_0210100   vacuolar protein sorting-associated protein VTA1, putative
Plasmodium falciparum PF3D7_0103000 this record   vacuolar protein sorting-associated protein VTA1, putative
Plasmodium knowlesi PKNH_0210600   vacuolar protein sorting-associated protein VTA1, putative
Plasmodium vivax PVX_081605   vacuolar protein sorting-associated protein VTA1, putative
Plasmodium yoelii PY01512   hypothetical protein
Schistosoma japonicum Sjp_0067670   Vacuolar protein sorting-associated protein VTA1 homolog, putative
Schistosoma mansoni Smp_094820   hypothetical protein
Schmidtea mediterranea mk4.000987.05   Vacuolar protein sorting-associated protein VTA1 homolog
Trypanosoma brucei gambiense Tbg972.7.8400   hypothetical protein, conserved
Trypanosoma brucei Tb927.7.7140   Vta1 like, putative
Trypanosoma congolense TcIL3000_0_52490   Vta1 like, putative
Trypanosoma cruzi TcCLB.504175.20   Vta1 like, putative
Trypanosoma cruzi TcCLB.508385.60   Vta1 like, putative

Essentiality

PF3D7_0103000 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.7.7140 Trypanosoma brucei significant gain of fitness in bloodstream forms (3 days) alsford
Tb927.7.7140 Trypanosoma brucei significant gain of fitness in bloodstream forms (6 days) alsford
Tb927.7.7140 Trypanosoma brucei significant gain of fitness in procyclic forms alsford
Tb927.7.7140 Trypanosoma brucei significant gain of fitness in differentiation of procyclic to bloodstream forms alsford
PBANKA_0210100 Plasmodium berghei Dispensable plasmo

Show/Hide essentiality data references
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Curated from literature

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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User comments

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Gene identifier PF3D7_0103000 (Plasmodium falciparum), vacuolar protein sorting-associated protein VTA1, putative
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TDR Targets Development Release v6, Revision: 1335 (10.Aug.2018)
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