Detailed view for PF3D7_0105900

Basic information

TDR Targets ID: 3180
Plasmodium falciparum, DNA binding protein, putative

Source Database / ID: PlasmoDB / PF3D7_0105900  GeneDB / PF3D7_0105900

pI: 8.9377 | Length (AA): 448 | MW (Da): 53423 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: ND

Pfam domains

PF01612   3'-5' exonuclease

Gene Ontology

Mouse over links to read term descriptions.
GO:0006139   nucleobase, nucleoside, nucleotide and nucleic acid metabolic process  
GO:0005622   intracellular  
GO:0008408   3'-5' exonuclease activity  
GO:0003677   DNA binding  
GO:0003676   nucleic acid binding  

Network

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models: 1

There is 1 model calculated for this protein. More info on this model, including the model itself is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
86 280 2fby (A) 36 229 28.00 0 1 0.63 -0.76

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Shows this level of upregulation in
This gene ranks in the upper 80-100% group of genes. gametocyte.
Upregulation Percent Ranking Shows this level of upregulation in
This gene ranks in the upper 60-80% group of genes. late schizont, late trophozoite.
Upregulation Percent Ranking Shows this level of upregulation in
This gene ranks in the mid 40-60% group of genes. sporozoite, early schizont, early trophozoite.
Show/Hide expression data references
  • PlasmoDB Data on upregulation of P. falciparum genes in different life cycle stages, combined from several microarray experiments available in PlasmoDB

Orthologs

Ortholog group members (OG5_146568)
Species Accession Gene Product
Babesia bovis BBOV_III010440   3'-5' exonuclease domain containing protein
Plasmodium berghei PBANKA_0207400   DNA binding protein, putative
Plasmodium falciparum PF3D7_0105900 this record   DNA binding protein, putative
Plasmodium knowlesi PKNH_0207600   DNA binding protein, putative
Plasmodium vivax PVX_081475   DNA binding protein, putative
Plasmodium yoelii PY06866   Ribonuclease D
Theileria parva TP02_0102   hypothetical protein

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Curated from literature

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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User comments

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Gene identifier PF3D7_0105900 (Plasmodium falciparum), DNA binding protein, putative
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TDR Targets Development Release v6, Revision: 1335 (10.Aug.2018)
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