Detailed view for Tc00.1047053506407.10

Basic information

TDR Targets ID: 31824
Trypanosoma cruzi, lysosomal alpha-mannosidase precursor, putative
Source Database / ID: TriTrypDB / Tc00.1047053506407.10  GeneDB / Tc00.1047053506407.10

pI: 6.8974 | Length (AA): 977 | MW (Da): 111196 | Number of Paralogs: 1

EC number(s): 3.2.1.24 | Enzyme, KEGG, Brenda (mouse over to display more information)

Signal peptide: Y | GPI Anchor: N (Show evidence) | Predicted trans-membrane segments: 1

Pfam domains

PF07748   Glyco_hydro_38C
PF09261   Alpha-mann_mid

Gene Ontology

Function: (mouse over links to read term descriptions)

GO:0003824   catalytic activity  
GO:0030246   carbohydrate binding  
GO:0015923   mannosidase activity  
GO:0008270   zinc ion binding  
GO:0004559   alpha-mannosidase activity  

Process: (mouse over links to read term descriptions)

GO:0006013   mannose metabolic process  
GO:0005975   carbohydrate metabolic process  
Metabolic Pathways

Other glycan degradation (KEGG)
Glycan structures - degradation (KEGG)

Functional classes

GO:0003674 molecular_function
GO:0008150 biological_process
GO:0009987 cellular process
GO:0016787 hydrolase activity

Structural information

Modbase 3D models: Tc00.1047053506407.10  

PDB structures: no structure available for this protein in the PDB.

Expression

No expression information available for this gene.

Antigenicity

Number of putative antigenic epitopes: 44
Cumulative epitope score: 49.4
Normalized epitope score: 5.1
Percentile: 79.7 (this protein belongs to the top 20.3% proteins in the genome of Trypanosoma cruzi, based on the predicted antigenicity).

[+/–]   More information on this prediction ...

Orthologs

OrthoMCL 4 cluster: OG4_12348
Number of Paralogs: 1

Ortholog group members from selected species:
Arabidopsis thaliana NP_201416   glycosyl hydrolase family 38 protein ... |   OrthoMCL
Arabidopsis thaliana NP_189306   glycosyl hydrolase family 38 protein ... |   OrthoMCL
Arabidopsis thaliana NP_196902   glycosyl hydrolase family 38 protein ... |   OrthoMCL
Arabidopsis thaliana NP_001118706   glycosyl hydrolase family 38 protein ... |   OrthoMCL
Arabidopsis thaliana NP_001031878   glycosyl hydrolase family 38 protein ... |   OrthoMCL
Arabidopsis thaliana NP_851037   glycosyl hydrolase family 38 protein ... |   OrthoMCL
Caenorhabditis elegans F55D10.1   CE28456 WBGene00018877 Alpha-mannosidase status:Partially_co... |   OrthoMCL
Drosophila melanogaster FBpp0079345   |   OrthoMCL
Drosophila melanogaster FBpp0079344   |   OrthoMCL
Drosophila melanogaster FBpp0079346   |   OrthoMCL
Drosophila melanogaster FBpp0079343   |   OrthoMCL
Drosophila melanogaster FBpp0079632   |   OrthoMCL
Drosophila melanogaster FBpp0079621   |   OrthoMCL
Homo sapiens ENSP00000395473   |   OrthoMCL
Mus musculus ENSMUSP00000034121   |   OrthoMCL
Oryza sativa NP_001067993   Os11g0525600 ... |   OrthoMCL
Oryza sativa NP_001064140   Os10g0140200 ... |   OrthoMCL
Schistosoma mansoni Smp_131580   lysosomal alpha-mannosidase (mannosidase alpha class 2b memb... |   OrthoMCL
Trypanosoma brucei gambiense Tbg972.10.3200   |   OrthoMCL
Trypanosoma brucei Tb927.10.2570   lysosomal alpha-mannosidase precursor, putative... |   OrthoMCL
Trypanosoma cruzi Tc00.1047053506195.120   lysosomal alpha-mannosidase precursor, putative... |   OrthoMCL
Trypanosoma cruzi Tc00.1047053506407.10 (this record).   lysosomal alpha-mannosidase precursor, putative... |   OrthoMCL
Trypanosoma vivax TvY486_1002590   |   OrthoMCL

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

Associated compounds / Druggability

Druggability index (range: 0 to 1): 0.6


  • Curated from literature

    No chemical compounds is associated to this gene

  • Predicted associations

    • Assayability

    Assay information

    Assay: Assayed; Source: BRENDA
    Description: An enzyme with this EC number or name or sequence has been assayed in Trypanosoma cruzi ( 1 );

    Reagent availability

    Reagent: Tc00.1047053506407.10; Type: cloned gene; Source: BRENDA
    Notes: A gene with this EC number or name or sequence has been cloned from Trypanosoma cruzi ( 1 );

    Reagent: Tc00.1047053506407.10; Type: purified protein; Source: BRENDA
    Notes: A protein with this EC number or name or sequence has been purified from Trypanosoma cruzi ( 1 );

    Bibliographic references

    No literature references are available for this gene.

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    User comments

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