Detailed view for PF3D7_0106400

Basic information

TDR Targets ID: 3185
Plasmodium falciparum, pre-rRNA-processing protein TSR2, putative

Source Database / ID: PlasmoDB / PF3D7_0106400  GeneDB / PF3D7_0106400

pI: 4.0958 | Length (AA): 156 | MW (Da): 18395 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: ND

Pfam domains

PF10273   Pre-rRNA-processing protein TSR2

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Network

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models: 0

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Shows this level of upregulation in
This gene ranks in the upper 80-100% group of genes. merozoite, sporozoite, early ring, early trophozoite, late ring, late trophozoite.
Upregulation Percent Ranking Shows this level of upregulation in
This gene ranks in the upper 60-80% group of genes. gametocyte, early schizont.
Show/Hide expression data references
  • PlasmoDB Data on upregulation of P. falciparum genes in different life cycle stages, combined from several microarray experiments available in PlasmoDB

Orthologs

Ortholog group members (OG5_129326)
Species Accession Gene Product
Arabidopsis thaliana AT5G27990   pre-rRNA-processing protein TSR2, conserved region-containing protein
Brugia malayi Bm1_36460   hypothetical protein
Candida albicans CaO19.2998   similar to S. cerevisiae YLR435W
Candida albicans CaO19.10515   similar to S. cerevisiae YLR435W
Caenorhabditis elegans CELE_Y51H4A.15   Protein Y51H4A.15
Dictyostelium discoideum DDB_G0270202   hypothetical protein
Drosophila melanogaster Dmel_CG14543   CG14543 gene product from transcript CG14543-RA
Echinococcus granulosus EgrG_001083600   Pre rRNA processing protein TSR2 region
Entamoeba histolytica EHI_169830   hypothetical protein, conserved
Echinococcus multilocularis EmuJ_001083600   Pre rRNA processing protein TSR2, region
Homo sapiens ENSG00000158526   TSR2, 20S rRNA accumulation, homolog (S. cerevisiae)
Loa Loa (eye worm) LOAG_04976   hypothetical protein
Mus musculus ENSMUSG00000025264   TSR2 20S rRNA accumulation
Neospora caninum NCLIV_051100   hypothetical protein, conserved
Oryza sativa 4345991   Os08g0508600
Plasmodium berghei PBANKA_0206900   pre-rRNA-processing protein TSR2, putative
Plasmodium falciparum PF3D7_0106400 this record   pre-rRNA-processing protein TSR2, putative
Plasmodium knowlesi PKNH_0207100   pre-rRNA-processing protein TSR2, putative
Plasmodium vivax PVX_081450   pre-rRNA-processing protein TSR2, putative
Plasmodium yoelii PY02262   hypothetical protein
Saccharomyces cerevisiae YLR435W   Tsr2p
Schistosoma mansoni Smp_029750   hypothetical protein
Toxoplasma gondii TGME49_237240   hypothetical protein

Essentiality

PF3D7_0106400 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_Y51H4A.15 Caenorhabditis elegans embryonic lethal wormbase
CELE_Y51H4A.15 Caenorhabditis elegans larval arrest wormbase
CELE_Y51H4A.15 Caenorhabditis elegans slow growth wormbase
PBANKA_0206900 Plasmodium berghei Essential plasmo
TGME49_237240 Toxoplasma gondii Probably essential sidik

Show/Hide essentiality data references
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Curated from literature

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets

Assayability

Assay information

No assay information for this target.

Reagent availability

  • Pfal007493AAA;
  • Type Source Notes
    soluble recombinant protein Structural Genomics for Pathogenic Protozoa (SGPP) Pfal007493; Recombinant protein: full-length; Source: P falciparum; hypothetical protein ;

Bibliographic References

No literature references available for this target.

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User comments

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Gene identifier PF3D7_0106400 (Plasmodium falciparum), pre-rRNA-processing protein TSR2, putative
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TDR Targets Development Release v6, Revision: 1335 (10.Aug.2018)
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