Detailed view for PF3D7_0202000

Basic information

TDR Targets ID: 3292
Plasmodium falciparum, knob-associated histidine-rich protein

Source Database / ID: PlasmoDB / PF3D7_0202000  GeneDB / PF3D7_0202000

pI: 9.6205 | Length (AA): 654 | MW (Da): 71303 | Paralog Number: 1

Signal peptide: Y | GPI Anchor: N | Predicted trans-membrane segments: 0

Pfam domains

No Pfam domain information for this protein.

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 10 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
44 74 2lpc (A) 155 185 29.00 0.13 0.02 0.350001 -0.45
359 497 3k66 (A) 247 392 29.00 0.62 0.01 0.571738 -1.71
375 492 1w9r (A) 6 115 30.00 0.13 0.08 0.513628 -1.18
17 88 2kfw (A) 104 180 29.00 0.011 0.01 -0.00573533 1.51
57 86 2k8i (A) 142 171 43.00 0.61 0.06 0.398119 0.62
62 108 1qwz (A) 11 56 30.00 0.6 0.01 0.404832 -0.89
374 556 4tql (A) 47 235 14.00 0.62 0 0.536344 -1.67
375 492 1w9r (A) 6 115 32.00 0.068 0.03 0.46692 -0.91
384 614 2dgj (A) 11 237 23.00 0.54 0.03 0.483153 -0.39
518 606 4dt5 (A) 15 106 31.00 0.81 0.03 0.388179 0.12

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein


Upregulation Percent Ranking Shows this level of upregulation in
This gene ranks in the upper 80-100% group of genes. merozoite, sporozoite, early ring, early schizont, early trophozoite, late ring, late schizont, late trophozoite.
Upregulation Percent Ranking Shows this level of upregulation in
This gene ranks in the lower 20-40% group of genes. gametocyte.
Show/Hide expression data references
  • PlasmoDB Data on upregulation of P. falciparum genes in different life cycle stages, combined from several microarray experiments available in PlasmoDB


Ortholog group members (OG5_136836)

Species Accession Gene Product
Mus musculus 102639325   predicted gene, 35663
Oryza sativa 4326289   Os01g0356800
Plasmodium berghei PBANKA_0927700   conserved Plasmodium protein, unknown function
Plasmodium falciparum PF3D7_1120600   conserved Plasmodium protein, unknown function
Plasmodium falciparum PF3D7_0202000 this record   knob-associated histidine-rich protein
Plasmodium knowlesi PKNH_0918300   conserved Plasmodium protein, unknown function
Plasmodium knowlesi PKNH_1325700   knob-associated histidine-rich protein, putative
Plasmodium vivax PVX_091660   hypothetical protein
Plasmodium vivax PVX_003520   knob-associated histidine-rich protein, putative
Plasmodium yoelii PY00892   hypothetical protein


PF3D7_0202000 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
PBANKA_0927700 Plasmodium berghei Dispensable plasmo
Show/Hide essentiality data references
  • wormbase C. elegans RNAi experiments WormBase web site,, release WS170
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets

Obtained from network model
No druggable targets predicted through repurposing network model


Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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User comments

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Gene identifier PF3D7_0202000 (Plasmodium falciparum), knob-associated histidine-rich protein
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