Detailed view for TcCLB.461927.9

Basic information

TDR Targets ID: 33136
Trypanosoma cruzi, adenosine monophosphate deaminase, putative
Source Database / ID:  TriTrypDB  GeneDB

pI: 6.4613 | Length (AA): 563 | MW (Da): 63499 | Paralog Number: 6

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG5

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00962   Adenosine/AMP deaminase

Gene Ontology

Mouse over links to read term descriptions.
GO:0032264   IMP salvage  
GO:0019239   deaminase activity  
GO:0003876   AMP deaminase activity  
GO:0009168   purine ribonucleoside monophosphate biosynthetic process  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 5 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1 261 2a3l (A) 584 839 41.00 0 1 0.86 -0.31
58 210 1vfl (A) 194 345 19.00 0 0.21 0.48 -0.51
1 246 2a3l (A) 584 828 42.00 0 1 0.884645 0.41
248 426 5inr (A) 58 217 30.00 0.95 0.04 0.17674 1.18
300 545 2a3l (A) 212 457 30.00 0 0.63 0.474445 2.25

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Lower 20-40% percentile epimastigote, metacyclic. Smircich P
Show/Hide expression data references
  • Smircich P Ribosome profiling reveals translation control as a key mechanism generating differential gene expression in Trypanosoma cruzi.

Orthologs

Ortholog group members (OG5_126856)

Species Accession Gene Product
Arabidopsis thaliana AT2G38280   AMP deaminase
Brugia malayi Bm1_54650   adenosine monophosphate deaminase
Candida albicans CaO19.8510   Adenosine/AMP deaminase similar to S. cerevisiae AMD1 (YML035C) involved in purine nucleotide metabolism
Candida albicans CaO19.891   Adenosine/AMP deaminase similar to S. cerevisiae AMD1 (YML035C) involved in purine nucleotide metabolism
Caenorhabditis elegans CELE_C34F11.3   Protein C34F11.3, isoform B
Cryptosporidium hominis Chro.40214   AMP deaminase
Cryptosporidium parvum cgd4_1890   adenosine monophosphate deaminase 2
Dictyostelium discoideum DDB_G0292266   AMP deaminase
Drosophila melanogaster Dmel_CG32626   AMP deaminase
Echinococcus granulosus EgrG_000392900   AMP deaminase 2
Entamoeba histolytica EHI_029100   AMP deaminase, putative
Entamoeba histolytica EHI_120890   AMP deaminase, putative
Echinococcus multilocularis EmuJ_000392900   AMP deaminase 2
Homo sapiens ENSG00000133805   adenosine monophosphate deaminase 3
Homo sapiens ENSG00000116748   adenosine monophosphate deaminase 1
Homo sapiens ENSG00000116337   adenosine monophosphate deaminase 2
Leishmania braziliensis LbrM.04.0320   adenosine monophosphate deaminase, putative,AMP deaminase, putative
Leishmania braziliensis LbrM.32.2780   AMP deaminase, putative,adenosine monophosphate deaminase-like protein
Leishmania braziliensis LbrM.34.4760   AMP deaminase, putative
Leishmania braziliensis LbrM.13.0790   AMP deaminase, putative,amp deaminase-like protein
Leishmania donovani LdBPK_322690.1   AMP deaminase, putative
Leishmania donovani LdBPK_040270.1   adenosine monophosphate deaminase, putative
Leishmania donovani LdBPK_354860.1   AMP deaminase, putative
Leishmania donovani LdBPK_130870.1   AMP deaminase, putative
Leishmania infantum LinJ.32.2690   AMP deaminase, putative,adenosine monophosphate deaminase-like protein
Leishmania infantum LinJ.35.4860   AMP deaminase, putative
Leishmania infantum LinJ.04.0270   adenosine monophosphate deaminase, putative,AMP deaminase, putative
Leishmania infantum LinJ.13.0870   AMP deaminase, putative,amp deaminase-like protein
Leishmania major LmjF.13.0980   AMP deaminase, putative,amp deaminase-like protein
Leishmania major LmjF.32.2550   AMP deaminase, putative,adenosine monophosphate deaminase-like protein
Leishmania major LmjF.35.4800   AMP deaminase, putative
Leishmania major LmjF.04.0280   adenosine monophosphate deaminase, putative,AMP deaminase, putative
Leishmania mexicana LmxM.13.0980   AMP deaminase, putative,amp deaminase-like protein
Leishmania mexicana LmxM.31.2550   AMP deaminase, putative,adenosine monophosphate deaminase-like protein
Leishmania mexicana LmxM.04.0280   adenosine monophosphate deaminase, putative,AMP deaminase, putative
Leishmania mexicana LmxM.34.4800   AMP deaminase, putative
Loa Loa (eye worm) LOAG_06535   hypothetical protein
Loa Loa (eye worm) LOAG_06536   AMP deaminase
Mus musculus ENSMUSG00000070385   adenosine monophosphate deaminase 1
Mus musculus ENSMUSG00000005686   adenosine monophosphate deaminase 3
Mus musculus ENSMUSG00000027889   adenosine monophosphate deaminase 2
Neospora caninum NCLIV_049460   adenosine monophosphate deaminase, putative
Oryza sativa 4344386   Os07g0693500
Oryza sativa 4338495   Os05g0349200
Onchocerca volvulus OVOC3634   AMP deaminase 2 homolog
Plasmodium berghei PBANKA_1344400   AMP deaminase, putative
Plasmodium falciparum PF3D7_1329400   AMP deaminase, putative
Plasmodium knowlesi PKNH_1271000   AMP deaminase, putative
Plasmodium vivax PVX_082415   adenosine/AMP deaminase, putative
Plasmodium yoelii PY01044   AMP deaminase homolog
Saccharomyces cerevisiae YML035C   AMP deaminase
Schistosoma japonicum Sjp_0036970   ko:K01490 AMP deaminase [EC3.5.4.6], putative
Schistosoma japonicum Sjp_0121980   AMP deaminase 2, putative
Schistosoma mansoni Smp_004120   AMP deaminase
Schmidtea mediterranea mk4.006992.03   AMP deaminase 2
Schmidtea mediterranea mk4.022116.01  
Schmidtea mediterranea mk4.007268.02   AMP deaminase 2
Schmidtea mediterranea mk4.025763.00  
Schmidtea mediterranea mk4.000649.05   Adenosine monophosphate deaminase 1
Schmidtea mediterranea mk4.016439.04   Adenosine monophosphate deaminase 1
Schmidtea mediterranea mk4.000135.03   AMP deaminase 2
Trypanosoma brucei gambiense Tbg972.11.17670   AMP deaminase, putative
Trypanosoma brucei gambiense Tbg972.9.3860   adenosine monophosphate deaminase, putative,AMP deaminase, putative
Trypanosoma brucei gambiense Tbg972.9.5600   AMP deaminase, putative
Trypanosoma brucei gambiense Tbg972.11.4470   AMP deaminase, putative
Trypanosoma brucei Tb927.9.7180   adenosine monophosphate deaminase, putative
Trypanosoma brucei Tb927.11.15750   AMP deaminase, putative
Trypanosoma brucei Tb927.9.9740   AMP deaminase, putative
Trypanosoma brucei Tb927.11.3850   AMP deaminase, putative
Trypanosoma congolense TcIL3000.11.3800   AMP deaminase, putative
Trypanosoma congolense TcIL3000_0_53780   adenosine monophosphate deaminase, putative
Trypanosoma congolense TcIL3000_9_3570   AMP deaminase, putative
Trypanosoma congolense TcIL3000_9_2410   adenosine monophosphate deaminase, putative
Trypanosoma cruzi TcCLB.506733.20   AMP deaminase, putative
Trypanosoma cruzi TcCLB.410589.10   AMP deaminase, putative
Trypanosoma cruzi TcCLB.511857.80   AMP deaminase, putative
Trypanosoma cruzi TcCLB.461927.9   adenosine monophosphate deaminase, putative
Trypanosoma cruzi TcCLB.506885.390   AMP deaminase, putative
Trypanosoma cruzi TcCLB.510729.10   AMP deaminase, putative
Trypanosoma cruzi TcCLB.508273.10   adenosine monophosphate deaminase-like protein, putative
Toxoplasma gondii TGME49_234280   AMP deaminase

Essentiality

TcCLB.461927.9 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb11.02.1340 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb11.02.1340 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb11.02.1340 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb11.02.1340 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
Tb09.211.1320 Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb09.211.1320 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb09.211.1320 Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb09.211.1320 Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
Tb09.160.5250 Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb09.160.5250 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb09.160.5250 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb09.160.5250 Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
Tb11.01.7390 Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb11.01.7390 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb11.01.7390 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb11.01.7390 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_C34F11.3 Caenorhabditis elegans larval arrest wormbase
CELE_C34F11.3 Caenorhabditis elegans slow growth wormbase
TGME49_234280 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Druggability index (range: 0 to 1): 0.5

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens adenosine monophosphate deaminase 2 Compounds References
Homo sapiens adenosine monophosphate deaminase 3 Compounds References
Arabidopsis thaliana AMP deaminase Compounds References
Oryctolagus cuniculus AMP deaminase 1 Compounds References
Trypanosoma brucei adenosine monophosphate deaminase, putative Compounds References
Trypanosoma brucei AMP deaminase, putative Compounds References
Homo sapiens adenosine monophosphate deaminase 1 Compounds References
Trypanosoma brucei AMP deaminase, putative Compounds References
Trypanosoma brucei AMP deaminase, putative Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0345 0.2544 0.2808
0.0141 0.3021 1
0.3033 0.814 1
0.0209 0.3215 1
0.3172 0.7654 1
0.4065 0.3379 0.4859
0.2581 0.8332 0.5
0.2441 0.4817 1
0.4387 0.5741 1
0.3172 0.7735 1
0.2172 0.4642 1
0.0333 0.4036 0.9713
0.1046 0.4805 1
0.149 0.4545 1
0.0129 0.3103 0.7978
0.049 0.2864 1
0.034 0.2584 0.6531
0.0332985 0.299904 1
0.0319347 0.975237 1
0.3351 0.598 1
0.0129 0.8676 0.5
0.3172 0.7735 1
0.404 0.6089 1
0.117722 1 1
0.0304 0.6953 1
0.3617 0.7815 1
0.0335 0.4026 0.9694
0.2255 0.6734 1
0.3389 0.6036 1
0.4218 0.6484 1
0.0442 0.4678 1
0.0465 0.5515 1
0.3513 0.8171 1
0.3617 0.7815 1
0.0319347 0.975237 1
0.01 0.8676 0.5
0.0117 0.3059 0.5
0.0332 1 1
0.0393 0.4787 1
0.252 0.4935 1
0.0117 0.3059 0.5
0.031 0.7112 1
0.0331 0.9369 1
0.3495 0.6989 1
0.1201 0.8855 1
0.4001 0.7758 1
0.0141 0.3021 1
0.0834 0.3212 1
0.1158 0.6004 1
0.5484 0.6326 1
0.0978 0.4712 1
0.5038 0.529 1
0.2505 0.4811 1
0.1904 0.512 1
0.3172 0.7735 1
0.2172 0.4642 1
0.0347 0.2558 0.2858
0.3901 0.7683 1
0.5729 0.6166 1
0.1949 0.5909 1
0.0055 0.2871 0.5
0.2569 0.4778 1
0.1391 0.2517 0.5
0.0316364 0.274095 0.496518
0.0307 0.2721 0.8246
0.0335 0.4026 0.9694
0.1158 0.6004 1
0.0183 1 0.5
0.2937 0.7168 1
0.0088 0.28 1
0.0209 0.2909 1
0.0335 0.4047 0.6522
0.0151 0.2515 0.5
0.0088 0.28 1
0.062 0.3351 1
0.01 0.8676 0.5
0.216 0.9992 1
0.0261 0.3082 0.7172
0.0129 0.8676 0.5
0.0055 0.2871 0.5
0.1484 1 1
0.0292 0.3193 1
0.0321883 0.291152 1
0.0129 0.872 1
0.0086 0.3024 0.5
0.3495 0.6989 1
0.2707 0.5057 1
0.0373 0.8043 1
0.1942 0.699 1
0.1016 0.3468 1
0.2049 0.4751 1
0.0321883 0.291152 1
0.2125 0.474 1
0.0308 0.3662 0.5659
0.0332 0.4024 0.9642
0.0178 0.3027 1
0.3835 0.5906 1
0.445 0.5666 1
0.0129 0.8676 0.5
0.3835 0.5906 1
0.3859 0.538 0.5
0.1642 0.4741 1
0.1198 0.4186 1
0.3617 0.7815 1
0.4742 0.7215 1
0.3786 0.759 1
0.0319 0.3502 0.9328
0.2174 0.9528 1
0.2586 0.87 1
0.1484 1 1
0.149 0.4545 1
0.3172 0.7735 1
0.0334 0.2556 0.9708
0.2386 0.6754 1
0.0303 0.3685 0.879
0.0129 0.8676 0.5
0.2125 0.474 1
0.0349 0.2587 0.3712
0.062 0.3351 1
0.0347 0.2558 0.2858
0.3835 0.5906 1
0.2851 0.4789 1
0.3172 0.7735 1
0.149 0.4545 1
0.2586 0.87 1
0.0294 0.3125 0.5352
0.0445 0.2566 0.3124
0.2049 0.4751 1
0.0129 0.872 1
0.0332 0.388 0.9452
0.0271 0.2625 0.5
0.0312858 0.275507 1
0.4001 0.7758 1
0.0095 1 0.5
0.4001 0.7758 1
0.3835 0.5906 1
0.2125 0.474 1
0.0234 0.2944 0.5
0.3865 0.7396 1
0.2937 0.7168 1
0.0178 0.3163 0.5
0.0312 0.389 1
0.3851 0.5923 1
0.2505 0.4811 1
0.0129 0.8676 0.5
0.019 1 0.5
0.0117 0.3059 0.5
0.2707 0.5057 1
0.0345 0.2544 0.2808
0.0789 0.8676 0.5
0.0517 0.4787 1
0.0189 0.4781 1
0.0341 0.2558 0.9709
0.2838 0.4924 1
0.3669 0.7606 1
0.0294 0.3125 0.5352
0.1604 0.3507 1
0.031 0.366 0.8941
0.2441 0.4817 1
0.466 0.7001 1
0.0117 0.3059 0.5
0.0306 0.8676 0.5
0.3457 0.4983 0.5
0.2049 0.4751 1
0.0208 0.8676 0.5
0.5038 0.529 1
0.3786 0.759 1
0.0209 0.2909 1
0.0312 0.3897 1
0.3835 0.5906 1
0.374 0.5908 1
0.2505 0.4811 1
0.0102 0.6452 0.6442
0.0349 0.2587 0.3737
0.0978 0.8676 0.5
0.2441 0.4817 1
0.1744 0.5061 1
0.4387 0.5741 1
0.0333 0.4039 0.973
0.0129 0.8676 0.5
0.012 0.2957 1
0.4239 0.6326 1
0.3495 0.6989 1
0.0319347 0.975237 1
0.0309 0.3682 0.3845
0.5033 0.5287 1
0.3401 0.4966 1
0.3513 0.8171 1
0.0234 0.2944 0.5
0.0332985 0.299904 1
0.137 1 1
0.4867 0.2964 0.5
0.117722 1 1
0.029 0.2905 1
0.0055 0.2871 0.5
0.0129 0.8676 0.5
0.0129 0.8676 0.5
0.0129 0.8676 0.5
0.3378 0.4617 0.5
0.0351 0.2618 0.4359
0.0129 0.8676 0.5
0.0312 0.3687 0.8354
0.0345 0.2563 0.2812
0.0333 1 1
0.1977 0.4744 1
0.0312 0.3897 1
0.3158 0.7548 1
0.0101 0.6059 0.6059
0.1721 0.3297 1
0.0352 0.2547 0.2894
0.117722 1 1
0.2679 0.4793 1
0.4218 0.6484 1
0.3617 0.7815 1
0.0055 0.2871 0.5
0.0129 0.258 1
0.0188 0.6301 0.6301
0.3158 0.7548 1
0.0129 0.3844 1
0.3513 0.8171 1
0.0064 0.2566 0.813
0.1241 0.5116 1
0.1016 0.3468 1
0.3158 0.7548 1
0.1391 0.2517 0.5
0.0333 0.4039 0.973
0.4708 0.6191 1
0.3533 0.7788 1
0.0338 0.4047 0.6526
0.1123 0.409 1
0.3034 0.8443 1
0.0129 0.8676 0.5
0.4193 0.6056 1
0.349 0.3937 1
0.2441 0.4817 1
0.1015 0.5532 1
0.0223 0.582 1
0.1061 0.9344 1
0.2019 0.4008 1
0.0803 0.415 0.5
0.2172 0.4642 1
0.0122 0.2564 0.8146
0.2706 0.4411 1
0.0323 0.3598 1
0.0831 0.3349 0.5
0.0236 0.3132 1
0.0202 0.8676 0.5
0.1222 0.3923 1
0.2125 0.474 1
0.0337 0.3879 1
0.0129 0.872 1
0.4218 0.6484 1
0.3835 0.5906 1
0.3304 0.6245 1
0.2172 0.4642 1
0.0237 0.4563 1
0.3495 0.6989 1
0.3172 0.7735 1
0.2552 0.6392 1
0.4708 0.6191 1
0.1546 0.4495 1
0.1744 0.5061 1
0.4742 0.7215 1
0.0345 0.2567 0.2822
0.0307 0.2721 0.8246
0.031 0.3817 0.9029
0.3669 0.7606 1
0.02 0.5775 1
0.4064 0.5989 1
0.2441 0.4817 1
0.4061 0.5635 1
0.3901 0.7683 1
0.117722 1 1
0.3814 0.7223 1
0.0333 0.4786 1
0.3172 0.7735 1
0.3495 0.6989 1
0.0406 0.2821 1
0.0055 0.2892 0.5
0.4742 0.7215 1

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier TcCLB.461927.9 (Trypanosoma cruzi), adenosine monophosphate deaminase, putative
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