Detailed view for PF3D7_0204700

Basic information

TDR Targets ID: 3315
Plasmodium falciparum, hexose transporter

Source Database / ID: PlasmoDB / PF3D7_0204700  GeneDB / PF3D7_0204700

pI: 8.7487 | Length (AA): 504 | MW (Da): 56417 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: ND

Pfam domains

PF00083   Sugar (and other) transporter

Gene Ontology

Mouse over links to read term descriptions.
GO:0022857   transmembrane transporter activity  
GO:0015749   monosaccharide transport  
GO:0015145   monosaccharide transmembrane transporter activity  
GO:0016021   integral to membrane  
GO:0016020   membrane  
GO:0022891   substrate-specific transmembrane transporter activity  
GO:0005215   transporter activity  
GO:0055085   transmembrane transport  
GO:0006810   transport  

Network

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models: 2

There are 2 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
19 484 1pw4 (A) 20 445 13.00 0 0.69 1.02 -1.29
290 474 2cfq (A) 5 186 15.00 0.000000000075 0.02 0.7 -2.15

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

Expression

Upregulation Percent Ranking Shows this level of upregulation in
This gene ranks in the upper 80-100% group of genes. merozoite, sporozoite, early ring, early schizont, early trophozoite, late ring, late schizont, late trophozoite.
Upregulation Percent Ranking Shows this level of upregulation in
This gene ranks in the upper 60-80% group of genes. gametocyte.
Show/Hide expression data references
  • PlasmoDB Data on upregulation of P. falciparum genes in different life cycle stages, combined from several microarray experiments available in PlasmoDB

Orthologs

Ortholog group members (OG5_127135)
Species Accession Gene Product
Arabidopsis thaliana AT3G05150   sugar transporter ERD6-like 8
Arabidopsis thaliana AT5G16150   plastidic glucose transporter
Brugia malayi Bm1_35495   Sugar transporter family protein
Candida albicans CaO19.2865   almost identical to C terminus of CaP19.2425
Candida albicans CaO19.2425   C terminus is almost identical to CaP19.2865
Candida albicans CaO19.10383   almost identical to C terminus of CaP19.2425
Candida albicans CaO19.9963   C terminus is almost identical to CaP19.2865
Caenorhabditis elegans CELE_H17B01.1   Protein FGT-1, isoform A
Drosophila melanogaster Dmel_CG1208   CG1208 gene product from transcript CG1208-RB
Drosophila melanogaster Dmel_CG43946   Glucose transporter 1
Echinococcus granulosus EgrG_000853700   solute carrier family 2 facilitated glucose
Echinococcus granulosus EgrG_000853500   solute carrier family 2 facilitated glucose
Echinococcus granulosus EgrG_000853600   General substrate transporter
Echinococcus granulosus EgrG_000853400   solute carrier family 2 facilitated glucose
Echinococcus granulosus EgrG_000972600   solute carrier family 2 facilitated glucose
Echinococcus multilocularis EmuJ_000972600   solute carrier family 2, facilitated glucose
Echinococcus multilocularis EmuJ_000853400   solute carrier family 2 facilitated glucose
Echinococcus multilocularis EmuJ_000853600   General substrate transporter
Echinococcus multilocularis EmuJ_000853700   solute carrier family 2 facilitated glucose
Echinococcus multilocularis EmuJ_000853500   solute carrier family 2 facilitated glucose
Homo sapiens ENSG00000181856   solute carrier family 2 (facilitated glucose transporter), member 4
Homo sapiens ENSG00000173262   solute carrier family 2 (facilitated glucose transporter), member 14
Homo sapiens ENSG00000059804   solute carrier family 2 (facilitated glucose transporter), member 3
Homo sapiens ENSG00000117394   solute carrier family 2 (facilitated glucose transporter), member 1
Loa Loa (eye worm) LOAG_09566   sugar transporter
Mus musculus ENSMUSG00000003153   solute carrier family 2 (facilitated glucose transporter), member 3
Mus musculus ENSMUSG00000018566   solute carrier family 2 (facilitated glucose transporter), member 4
Mus musculus ENSMUSG00000028645   solute carrier family 2 (facilitated glucose transporter), member 1
Neospora caninum NCLIV_051560   Glucose transporter 1A, related
Oryza sativa 4325804   Os01g0133400
Plasmodium berghei PBANKA_0302500   hexose transporter
Plasmodium falciparum PF3D7_0204700 this record   hexose transporter
Plasmodium knowlesi PKNH_0416200   hexose transporter, putative
Plasmodium vivax PVX_003665   hexose transporter
Plasmodium yoelii PY00899   putative sugar transporter
Saccharomyces cerevisiae YBR241C   hypothetical protein
Schistosoma japonicum Sjp_0132820   Solute carrier family 2, facilitated glucose transporter member 3, putative
Schistosoma japonicum Sjp_0041820   Solute carrier family 2, facilitated glucose transporter member 1, putative
Schistosoma japonicum Sjp_0212170   ko:K07299 MFS transporter, SP family, solute carrier family 2 (facilitated, putative
Schistosoma japonicum Sjp_0219380   IPR005828,General substrate transporter,domain-containing
Schistosoma japonicum Sjp_0093040   ko:K07191 MFS transporter, SP family, solute carrier family 2 (facilitated, putative
Schistosoma japonicum Sjp_0305070   Solute carrier family 2, facilitated glucose transporter member 4, putative
Schistosoma mansoni Smp_046790   glucose transport protein
Schistosoma mansoni Smp_012440   glucose transport protein
Schistosoma mansoni Smp_105410   glucose transport protein
Schistosoma mansoni Smp_127200   hypothetical protein
Schmidtea mediterranea mk4.003679.04  
Schmidtea mediterranea mk4.003768.03  
Schmidtea mediterranea mk4.003863.01   Glucose transporter type 1
Schmidtea mediterranea mk4.059399.02  
Schmidtea mediterranea mk4.003679.02  
Schmidtea mediterranea mk4.006187.00  
Schmidtea mediterranea mk4.003768.02  
Schmidtea mediterranea mk4.010027.00  
Schmidtea mediterranea mk4.004966.07  
Schmidtea mediterranea mk4.012121.00  
Schmidtea mediterranea mk4.003998.00  
Schmidtea mediterranea mk4.007746.00  
Schmidtea mediterranea mk4.020573.02  
Schmidtea mediterranea mk4.019915.00  
Schmidtea mediterranea mk4.004966.06  
Schmidtea mediterranea mk4.014339.00  
Schmidtea mediterranea mk4.003863.02  
Toxoplasma gondii TGME49_214320   facilitative glucose transporter GT1
Trichomonas vaginalis TVAG_244110   conserved hypothetical protein

Essentiality

PF3D7_0204700 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
TGME49_214320 Toxoplasma gondii Essentiality uncertain sidik

Show/Hide essentiality data references
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930

Phenotypes and Validation (curated)

Annotated phenotypes:

Affected Entity Phenotypic quality Occurs in Occurs at Evidence Observed in Drugs/Inhibitors
growth (GO:0040007) lethal (sensu genetics) (PATO:0000718) multi-cellular organism (CARO:0000012) bloodstream stage (PLO:0040) in vivo inhibition (TDR:00016) Plasmodium berghei No drug identifiers listed for this gene.
Annotator: saralph@unimelb.edu.au. Comment: Drug: 3-O-((undec-10-en)-yl)-d-glucose. . References: 12792024 15107012 15251446 16361099
growth (GO:0040007) lethal (sensu genetics) (PATO:0000718) multi-cellular organism (CARO:0000012) bloodstream stage (PLO:0040) in vivo inhibition (TDR:00016) Plasmodium falciparum No drug identifiers listed for this gene.
Annotator: saralph@unimelb.edu.au. Comment: Drug: 3-O-((undec-10-en)-yl)-d-glucose. . References: 12792024 15107012 15251446 16361099
growth (GO:0040007) lethal (sensu genetics) (PATO:0000718) multi-cellular organism (CARO:0000012) bloodstream stage (PLO:0040) in vivo inhibition (TDR:00016) Plasmodium vivax No drug identifiers listed for this gene.
Annotator: saralph@unimelb.edu.au. Comment: Drug: 3-O-((undec-10-en)-yl)-d-glucose. . References: 12792024 15107012 15251446 16361099

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Druggability index (range: 0 to 1): 0.4

Curated from literature

813 chemical compounds are associated with this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Rattus norvegicus Solute carrier family 2, facilitated glucose transporter member 1 Compounds References
Homo sapiens solute carrier family 2 (facilitated glucose transporter), member 3 Compounds References
Homo sapiens solute carrier family 2 (facilitated glucose transporter), member 1 Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets

Assayability

Assay information

  • Inhibition of D-glucose uptake mediated by PfHT expressed in Xenopus oocytes ChEMBL
  • Inhibition of D-glucose uptake mediated by PfHT expressed in Xenopus oocytes
  • Inhibition of [3H]glucose uptake at Plasmodium falciparum HT expressed in Xenopus laevis oocytes ChEMBL
  • Inhibition of [3H]glucose uptake at Plasmodium falciparum HT expressed in Xenopus laevis oocytes
  • ChEMBL
  • ST_JUDE_LEISH: Cytotoxicity against transgenic Leishmania Mexicana promastigotes LmPfHT that are glucose transport deficient and complemented with the Plasmodium falciparum hexose transporter. Activity is measured by by DNA content using SYBR green in vitro
  • ChEMBL
  • ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmPfHT that are glucose transport deficient and complemented with the Plasmodium falciparum hexose transporter. Activity is measured by by DNA content using SYBR green in vitro

Reagent availability

No reagent availability information for this target.

Bibliographic References

4 literature references were collected for this gene.

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Gene identifier PF3D7_0204700 (Plasmodium falciparum), hexose transporter
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