Detailed view for PF3D7_0208000

Basic information

TDR Targets ID: 3347
Plasmodium falciparum, serine repeat antigen 1
Source Database / ID:  PlasmoDB   |   GeneDB   |   MPMP

pI: 8.0617 | Length (AA): 994 | MW (Da): 115496 | Paralog Number: 7

Signal peptide: Y | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG3

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00112   Papain family cysteine protease

Gene Ontology

Mouse over links to read term descriptions.
GO:0005575   cellular_component  
GO:0008234   cysteine-type peptidase activity  
GO:0006508   proteolysis  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
427 755 1xkg (A) 4 287 19.00 0 1 0.36 0.66
712 753 1cqd (A) 160 196 57.00 0.000055 0.75 0.59 -0.4
459 775 4qrx (A) 20 319 23.00 0 1 0.356913 0.63
513 778 2wbf (X) 563 827 67.00 0 1 1.14761 -1.39

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

PDB tag
  • 2WBF:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date
PDB tag
  • 3CH2:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date
PDB tag
  • 3CH3:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date

Expression

Upregulation Percent Ranking Stage Dataset
Mid 40-60% percentile intra-erythrocytic - 0 hs, intra-erythrocytic - 40 hs, intra-erythrocytic - 48 hs, Ring, Sporozoite, Female Gametocyte, Male Gametocyte. Otto TD Zanghi G Lasonder E
Upregulation Percent Ranking Stage Dataset
Lower 20-40% percentile intra-erythrocytic - 8 hs, intra-erythrocytic - 32 hs, Oocyst. Otto TD Zanghi G
Upregulation Percent Ranking Stage Dataset
Lower 0-20% percentile intra-erythrocytic - 16 hs, intra-erythrocytic - 24 hs. Otto TD
Show/Hide expression data references
  • Zanghi G A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection.
  • Otto TD New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq.
  • Lasonder E Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression.

Orthologs

Ortholog group members (OG5_132467)

Species Accession Gene Product
Plasmodium berghei PBANKA_0305100   serine repeat antigen 1
Plasmodium berghei PBANKA_0304900   serine repeat antigen 3
Plasmodium berghei PBANKA_0305000   serine repeat antigen 2
Plasmodium berghei PBANKA_0304800   serine repeat antigen 4
Plasmodium falciparum PF3D7_0207400   serine repeat antigen 7
Plasmodium falciparum PF3D7_0207500   serine repeat antigen 6
Plasmodium falciparum PF3D7_0207600   serine repeat antigen 5
Plasmodium falciparum PF3D7_0207700   serine repeat antigen 4
Plasmodium falciparum PF3D7_0207800   serine repeat antigen 3
Plasmodium falciparum PF3D7_0207900   serine repeat antigen 2
Plasmodium falciparum PF3D7_0208000   serine repeat antigen 1
Plasmodium falciparum PF3D7_0902800   serine repeat antigen 9
Plasmodium knowlesi PKNH_0413200   cysteine protease, putative
Plasmodium knowlesi PKNH_0413400   cysteine protease, putative
Plasmodium knowlesi PKNH_0413700   cysteine protease, putative
Plasmodium knowlesi PKNH_0413600   cysteine protease, putative
Plasmodium knowlesi PKNH_0413100   cysteine protease, putative
Plasmodium vivax PVX_003850   serine-repeat antigen 2 (SERA)
Plasmodium vivax PVX_003800   serine-repeat antigen (SERA)
Plasmodium vivax PVX_003840   serine-repeat antigen 3 (SERA)
Plasmodium vivax PVX_003805   serine-repeat antigen (SERA), putative
Plasmodium vivax PVX_003830   serine-repeat antigen 5 (SERA)
Plasmodium vivax PVX_003820   serine-repeat antigen 4 (SERA), putative
Plasmodium vivax PVX_003845   serine-repeat antigen 4 (SERA)
Plasmodium vivax PVX_003795   serine-repeat antigen (SERA)
Plasmodium yoelii PY00292   Papain family cysteine protease, putative
Plasmodium yoelii PY00293   Papain family cysteine protease, putative
Plasmodium yoelii PY00291   SERA-3
Plasmodium yoelii PY02062   SERA-2
Theileria parva TP04_0599   hypothetical protein
Theileria parva TP04_0598   hypothetical protein

Essentiality

PF3D7_0208000 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
PBANKA_0304800 Plasmodium berghei Slow plasmo
PBANKA_0305000 Plasmodium berghei Dispensable plasmo
PBANKA_0305100 Plasmodium berghei Dispensable plasmo
Show/Hide essentiality data references
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Druggability index (range: 0 to 1): 0.3

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Leishmania major cathepsin L-like protease 348 aa 20.9% 292 aa Compounds References
Leishmania major cathepsin L-like protease 348 aa 21.1% 298 aa Compounds References
Leishmania major cathepsin L-like protease 348 aa 20.8% 298 aa Compounds References
Leishmania major cathepsin L-like protease 348 aa 20.6% 292 aa Compounds References
Leishmania major cathepsin L-like protease 348 aa 20.8% 298 aa Compounds References
Capra hircus Cathepsin H 335 aa 22.3% 287 aa Compounds References
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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User comments

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Gene identifier PF3D7_0208000 (Plasmodium falciparum), serine repeat antigen 1
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