Detailed view for TcCLB.505945.20

Basic information

TDR Targets ID: 33681
Trypanosoma cruzi, ribonuclease mar1, putative

Source Database / ID:  TriTrypDB  GeneDB

pI: 7.6133 | Length (AA): 196 | MW (Da): 21436 | Paralog Number: 3

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00857   Isochorismatase family

Gene Ontology

Mouse over links to read term descriptions.
GO:0003824   catalytic activity  
GO:0008152   metabolic process  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1 196 1x9g (A) 1 192 51.00 0 1 1.69 -1.8
2 196 1yzv (A) 2 196 97.00 0 1 2.24 -2.49
2 196 1yzv (A) 2 196 97.00 0 1 2.2467 -1.9

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

  • 1YZV:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile epimastigote. Smircich P
Upregulation Percent Ranking Stage Dataset
Mid 40-60% percentile metacyclic. Smircich P
Show/Hide expression data references
  • Smircich P Ribosome profiling reveals translation control as a key mechanism generating differential gene expression in Trypanosoma cruzi.

Orthologs

Ortholog group members (OG5_129244)

Species Accession Gene Product
Brugia malayi Bm1_51490   isochorismatase family protein
Caenorhabditis elegans CELE_F35G2.2   Protein F35G2.2
Dictyostelium discoideum DDB_G0284901   hypothetical protein
Dictyostelium discoideum DDB_G0285041   hypothetical protein
Drosophila melanogaster Dmel_CG11333   CG11333 gene product from transcript CG11333-RA
Drosophila melanogaster Dmel_CG3663   CG3663 gene product from transcript CG3663-RA
Echinococcus granulosus EgrG_001024400   isochorismatase domain containing protein 2
Echinococcus multilocularis EmuJ_001024400   isochorismatase domain containing protein 2
Homo sapiens ENSG00000066583   isochorismatase domain containing 1
Homo sapiens ENSG00000063241   isochorismatase domain containing 2
Leishmania braziliensis LbrM.12.0080   ribonuclease mar1
Leishmania donovani LdBPK_120060.1   hypothetical protein, conserved
Leishmania infantum LinJ.12.0007   MAR1 ribonuclease, putative
Leishmania major LmjF.12.0060   ribonuclease mar1
Leishmania mexicana LmxM.12.0060   ribonuclease mar1
Loa Loa (eye worm) LOAG_15045   isochorismatase
Loa Loa (eye worm) LOAG_00074   hypothetical protein
Mus musculus ENSMUSG00000086784   isochorismatase domain containing 2a
Mus musculus ENSMUSG00000024601   isochorismatase domain containing 1
Mus musculus ENSMUSG00000052605   isochorismatase domain containing 2b
Onchocerca volvulus OVOC6895  
Schistosoma japonicum Sjp_0013760   Isochorismatase domain-containing protein 1, putative
Schistosoma mansoni Smp_000630   isochorismatase family protein
Schmidtea mediterranea mk4.007275.00  
Schmidtea mediterranea mk4.007802.00  
Trypanosoma cruzi TcCLB.509553.30   ribonuclease mar1, putative
Trypanosoma cruzi TcCLB.509553.40   ribonuclease mar1, putative
Trypanosoma cruzi TcCLB.505945.20   ribonuclease mar1, putative
Trypanosoma cruzi TcCLB.505945.30   ribonuclease mar1, putative

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.


Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets

Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

  • Tcru003547AAA;
  • Type Source Notes
    soluble recombinant protein Structural Genomics for Pathogenic Protozoa (SGPP) Tcru003547; Recombinant protein: full-length; Source: T cruzi; ribonuclease MAR1 ;

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier TcCLB.505945.20 (Trypanosoma cruzi), ribonuclease mar1, putative
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