Detailed view for TcCLB.504257.30

Basic information

TDR Targets ID: 34380
Trypanosoma cruzi, S-adenosylmethionine decarboxylase proenzyme, putative
Source Database / ID:  TriTrypDB  GeneDB

pI: 4.659 | Length (AA): 370 | MW (Da): 42154 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG4

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF01536   Adenosylmethionine decarboxylase

Gene Ontology

Mouse over links to read term descriptions.
GO:0004014   adenosylmethionine decarboxylase activity  
GO:0008295   spermidine biosynthetic process  
GO:0006597   spermine biosynthetic process  

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
26 356 1jl0 (A) 5 328 28.00 0 1 1.22 -1.35
28 310 1jl0 (A) 7 290 33.00 0 1 1.24 -1.13
26 357 1jl0 (A) 5 329 29.00 0 1 1.2667 -0.77
87 357 5tvo (A) 87 356 74.00 0 1 1.60503 -0.99

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_128279)

Species Accession Gene Product
Arabidopsis thaliana AT5G18930   S-adenosylmethionine decarboxylase
Arabidopsis thaliana AT3G02470   conserved peptide upstream open reading frame 9
Arabidopsis thaliana AT3G25570   S-adenosylmethionine decarboxylase
Arabidopsis thaliana AT5G15950   S-adenosylmethionine decarboxylase proenzyme 2
Brugia malayi Bm1_26830   S-adenosylmethionine decarboxylase proenzyme
Candida albicans CaO19.8199   S-adenosylmethionine decarboxylase
Candida albicans CaO19.568   S-adenosylmethionine decarboxylase
Caenorhabditis elegans CELE_F47G4.7   Protein SMD-1
Dictyostelium discoideum DDB_G0275567   S-adenosylmethionine decarboxylase
Drosophila melanogaster Dmel_CG5029   S-adenosylmethionine decarboxylase
Echinococcus granulosus EgrG_000713300   S adenosylmethionine decarboxylase proenzyme
Echinococcus multilocularis EmuJ_000713300   S adenosylmethionine decarboxylase proenzyme
Homo sapiens ENSG00000123505   adenosylmethionine decarboxylase 1
Leishmania braziliensis LbrM.30.3100   S-adenosylmethionine decarboxylase
Leishmania donovani LdBPK_303150.1   S-adenosylmethionine decarboxylase
Leishmania infantum LinJ.30.3150   S-adenosylmethionine decarboxylase
Leishmania major LmjF.30.3110   S-adenosylmethionine decarboxylase
Leishmania mexicana LmxM.29.3110   S-adenosylmethionine decarboxylase proenzyme
Loa Loa (eye worm) LOAG_06310   S-adenosylmethionine decarboxylase proenzyme
Mus musculus ENSMUSG00000075232   S-adenosylmethionine decarboxylase 1
Mus musculus ENSMUSG00000063953   S-adenosylmethionine decarboxylase 2
Oryza sativa 4336294   Os04g0498600
Oryza sativa 4347103   Os09g0424300
Oryza sativa 4329955   Os02g0611200
Saccharomyces cerevisiae YOL052C   adenosylmethionine decarboxylase SPE2
Schmidtea mediterranea mk4.011284.00   S-adenosylmethionine decarboxylase proenzyme
Schmidtea mediterranea mk4.012677.00   S-adenosylmethionine decarboxylase proenzyme
Schmidtea mediterranea mk4.004908.00   S-adenosylmethionine decarboxylase proenzyme
Schmidtea mediterranea mk4.012519.01   S-adenosylmethionine decarboxylase proenzyme
Schmidtea mediterranea mk4.003329.11   S-adenosylmethionine decarboxylase proenzyme
Trypanosoma brucei gambiense Tbg972.6.4230   S-adenosylmethionine decarboxylase
Trypanosoma brucei Tb927.6.4410   S-adenosylmethionine decarboxylase
Trypanosoma brucei Tb927.6.4460   S-adenosylmethionine decarboxylase
Trypanosoma brucei Tb11.v5.0903   S-adenosylmethionine decarboxylase proenzyme, putative
Trypanosoma congolense TcIL3000_6_3880   S-adenosylmethionine decarboxylase proenzyme, putative
Trypanosoma cruzi TcCLB.504257.30   S-adenosylmethionine decarboxylase proenzyme, putative
Trypanosoma cruzi TcCLB.509167.120   S-adenosylmethionine decarboxylase proenzyme, putative

Essentiality

TcCLB.504257.30 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.6.4410 Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb927.6.4410 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb927.6.4410 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.6.4410 Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
Show/Hide essentiality data references
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Druggability index (range: 0 to 1): 0.6

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Rattus norvegicus S-adenosylmethionine decarboxylase 1 Compounds References
Homo sapiens adenosylmethionine decarboxylase 1 Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0209 0.7523 1
0.0126 0.335 1
0.0325 1 1
0.1347 0.399 1
0.0417 0.7102 0.6814
0.0209 0.4681 1
0.0808 0.4675 0.7001
0.0433 0.2503 0.8329
0.0651 0.2819 0.6438
0.0663 0.3625 0.5984
0.1113 0.3385 1
0.0709 0.3703 0.6006
0.0755 0.393 0.7823
0.0109 0.3925 1
0.0533 0.3305 1
0.0762 0.5627 0.7466
0.1236 0.7705 1
0.0527 1 0.5
0.1336 1 0.5
0.0545 0.5077 0.4175
0.0209 0.6053 1
0.0641 1 0.5
0.0356 0.3632 0.5
0.0452 1 1
0.1247 0.3658 1
0.0682 0.3966 0.5975
0.0215 1 1
0.064 0.3973 1
0.0644 0.3644 1
0.0651 0.2819 0.6438
0.089 0.3541 1
0.0774 0.2884 0.7497
0.077 0.7177 1
0.0761 0.4591 1
0.1142 1 1
0.0418 0.298 0.475
0.0129 1 0.5
0.1362 0.8648 1
0.0804 0.5631 0.7264
0.0706 0.4076 0.6087
0.0129 0.5563 0.5
0.0777 0.3029 1
0.0225 0.3121 0.5
0.0504 0.6567 1
0.0437 0.3698 0.8122
0.0655 0.2783 0.574
0.068 0.3954 0.5797
0.0418 0.298 0.475
0.0657 0.3627 0.5984
0.0811 0.4652 0.6905
0.0672 0.397 0.597
0.064 0.4674 0.7295
0.0325 0.2884 1
0.0945 0.5199 0.78
0.0945 0.5199 0.78
0.0794 0.3193 1
0.0651 0.2819 0.6438
0.1365 0.8916 1
0.0092 0.2608 0.5
0.0129 0.4499 1
0.0108 1 0.5
0.0655 0.3624 0.582
0.0104 0.2632 1
0.0236 0.7594 1
0.0774 0.2947 1
0.0526 0.2754 0.6307
0.0655 0.2783 0.574
0.0919 0.5216 0.7716
0.0417 0.2977 0.7998
0.1113 0.3385 1
0.0548 0.3056 0.4791
0.0107 1 0.5
0.0571 0.5454 1
0.0642 0.4533 0.7406
0.0544 0.3358 1
0.0651 0.2819 0.6438
0.0689 0.3967 0.5952
0.0667 0.4603 0.5753
0.0651 0.2819 0.6438
0.0684 0.3663 0.5872
0.0678 0.3917 0.5742
0.0531 0.3323 1
0.0754 1 1
0.0686 0.3787 0.5984
0.0915 0.5142 0.8433
0.1004 0.602 1
0.0916 0.5199 0.7798
0.1014 1 0.5
0.0432 0.2536 1
0.0424 0.2986 0.3863
0.1339 0.4052 1
0.1335 1 1
0.0352 0.7001 1
0.0541 0.6705 1
0.0129 0.4232 1
0.0926 0.4828 0.7891
0.0659 0.3618 0.5793
0.034 0.9848 1
0.044 1 0.5
0.0588 1 1
0.067 0.4649 0.5962
0.0684 0.3663 0.5872
0.077 0.7177 1
0.0433 0.2503 0.8329
0.0267806 0.721874 1
0.0363 0.3439 0.5
0.112 0.4713 1
0.0636 0.4615 0.7323
0.0641 0.4612 0.7263
0.0812 0.4523 0.6764
0.1114 1 0.5
0.0208 1 0.5
0.1452 0.4426 1
0.0668 0.4677 0.6028
0.0371 1 0.5
0.0129 0.5 0.5
0.0107 1 0.5
0.0644 0.3945 0.7189
0.1102 0.328 1
0.0363 0.3439 0.5
0.0433 0.2503 0.8329
0.0921 0.5525 0.776
0.0363 0.3439 0.5
0.0648 0.3964 1
0.1287 1 1
0.067 0.4865 0.9494
0.0209 0.2566 1
0.0419 0.2966 0.3809
0.0129 0.7263 0.5
0.0433 0.2503 0.8329
0.1106 0.3672 1
0.0204 1 0.5
0.0638 0.3376 0.7732
0.0364001 0.810216 1
0.0235 1 0.5
0.0643 0.3883 1
0.094 0.5232 0.7838
0.0815 0.4701 0.7025
0.0431 0.2594 1
0.0218 1 1
0.042 0.3047 0.8051
0.0422 0.2974 0.3827
0.0109 0.3925 1
0.0239 0.4388 1
0.1348 0.4052 1
0.0419 0.4545 0.3809
0.0641 0.3596 0.578
0.095 0.526 0.7891
0.0684 0.3663 0.5872
0.0766 0.4236 0.7003
0.0794 0.3193 1
0.0367 1 0.5
0.0773 0.5619 0.7176
0.0256 0.4735 1
0.0422 0.3017 0.3823
0.0805 1 1
0.0526 0.2754 0.6307
0.0228 1 0.5
0.0677 0.2958 0.5793
0.0433 0.2503 0.8329
0.0424 0.2966 0.3827
0.0129 1 0.5
0.0655 0.3624 0.582
0.067 0.4649 0.5962
0.0882 0.3356 1
0.0681 0.4663 0.5917
0.0211 1 1
0.0209 0.5223 1
0.0111 1 0.5
0.0665 0.3606 0.599
0.0794 0.56 0.7176
0.0779 0.5658 0.7197
0.0756 0.459 1
0.0992 0.3011 1
0.0794 0.4654 0.6961
0.0651 0.2819 0.6438
0.0778 0.9122 1
0.0761 1 0.5
0.0827 0.4449 0.6672
0.0774 0.5651 0.7466
0.064 0.3973 1
0.0999 1 1
0.0806 0.4657 0.6904
0.0955 0.5137 0.771
0.0648 0.2605 1
0.0368 0.8124 0.5
0.0081 0.3969 0.5
0.0492 0.3852 1
0.067 0.4649 0.5962
0.0531 0.6011 0.935
0.067 0.4658 0.5943
0.089 1 1
0.0882 0.3448 1
0.0808 0.4675 0.7001
0.0109 0.3925 1
0.0789 0.5646 0.7462
0.0782 1 1
0.1013 1 0.5
0.0504 0.6567 1
0.0323 0.3636 1
0.0548 0.3066 0.4809
0.0644 0.3945 0.7189
0.0371 1 0.5
0.0418 0.254 0.8027
0.0565 0.9974 1
0.0207 0.6677 0.6677
0.0541 0.3156 1
0.0433 0.2503 0.8329
0.1335 0.8162 1
0.0338 1 0.5
0.081 0.5677 0.7104
0.0256 0.4735 1
0.0316 0.328 0.8704
0.0258 1 0.5
0.0894 0.3439 1
0.0339 0.9948 1
0.0769 0.2943 1
0.0671 0.4663 0.6007
0.0544 0.3358 1
0.0234 1 0.5
0.0352 0.7001 1
0.081 0.4594 0.6589
0.0777 0.5642 0.7451
0.0118 0.4265 1
0.0808 0.4675 0.7001
0.0437 0.3698 0.8122
0.0111 1 0.5
0.0778 0.9122 1
0.0129 0.2723 1
0.0118 0.4265 1
0.0216 0.2892 0
0.0999 0.3957 1
0.0793 0.5631 0.7259
0.0546181 0.384786 0.669826
0.0693 0.3513 0.5813
0.0108 1 0.5
0.0816 0.4483 0.6724
0.0684 0.3663 0.5872
0.0211 1 1
0.0107 0.2762 0.17
0.0104 1 0.5
0.0672 0.3624 0.5824
0.0548 0.3022 0.6318
0.0655 0.3619 0.5982
0.0996 0.4031 1
0.0536 0.3916 0.7772
0.0911 1 1
0.0697 0.3847 0.6011

Assayability

Assay information

  • BRENDA Assay
  • An enzyme with this EC number or name or sequence has been assayed in Trypanosoma cruzi ( 2 )

Reagent availability

  • Reagent:
  • Target Type Source Notes
    TcCLB.504257.30 purified protein BRENDA A protein with this EC number or name or sequence has been purified from Trypanosoma cruzi ( 2 )

Bibliographic References

29 literature references were collected for this gene.

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Gene identifier TcCLB.504257.30 (Trypanosoma cruzi), S-adenosylmethionine decarboxylase proenzyme, putative
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