pI: 5.2909 |
Length (AA): 129 |
MW (Da): 15063 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 2 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
4 | 127 | 2c35 (A) | 14 | 139 | 28.00 | 0 | 0.91 | 1.36254 | -0.69 |
5 | 127 | 2c35 (A) | 15 | 139 | 33.00 | 0.00000000026 | 1 | 1.36539 | -0.5 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_128606)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT5G09920 | RNA polymerase II, Rpb4, core protein |
Babesia bovis | BBOV_III006040 | RNA polymerase Rpb4 family protein |
Brugia malayi | Bm1_25045 | DNA-directed RNA polymerase II 16 kDa polypeptide, putative |
Candida albicans | CaO19.7786 | similar to N terminus of S. cerevisiae RPB4 (YJL140W) RNA polymerase II fourth largest subunit. |
Candida albicans | CaO19.145 | similar to C terminus of S. cerevisiae RPB4 (YJL140W) RNA polymerase II fourth largest subunit. |
Candida albicans | CaO19.146 | similar to N terminus of S. cerevisiae RPB4 (YJL140W) RNA polymerase II fourth largest subunit. |
Candida albicans | CaO19.7785 | similar to C terminus of S. cerevisiae RPB4 (YJL140W) RNA polymerase II fourth largest subunit. |
Caenorhabditis elegans | CELE_F43E2.2 | Protein RPB-4 |
Cryptosporidium parvum | cgd3_4320 | conserved hypothetical protein |
Dictyostelium discoideum | DDB_G0282739 | DNA-directed RNA polymerase II subunit 4 |
Drosophila melanogaster | Dmel_CG43662 | CG43662 gene product from transcript CG43662-RF |
Echinococcus granulosus | EgrG_000089400 | DNA directed RNA polymerase II subunit |
Echinococcus multilocularis | EmuJ_000089400 | DNA directed RNA polymerase II subunit |
Homo sapiens | ENSG00000144231 | polymerase (RNA) II (DNA directed) polypeptide D |
Loa Loa (eye worm) | LOAG_07020 | DNA-directed RNA polymerase II polypeptide |
Mus musculus | ENSMUSG00000024258 | polymerase (RNA) II (DNA directed) polypeptide D |
Neospora caninum | NCLIV_031640 | DNA-directed RNA polymerase II, putative |
Oryza sativa | 4328083 | Os02g0116900 |
Plasmodium berghei | PBANKA_0303200 | DNA-directed RNA polymerase II 16 kDa subunit, putative |
Plasmodium falciparum | PF3D7_0205500 | DNA-directed RNA polymerase II 16 kDa subunit, putative |
Plasmodium knowlesi | PKNH_0415400 | DNA-directed RNA polymerase I subunit, putative |
Plasmodium vivax | PVX_003705 | DNA-directed RNA polymerase II 16 kDa subunit, putative |
Plasmodium yoelii | PY02525 | RNA polymerase Rpb4 |
Saccharomyces cerevisiae | YJL140W | DNA-directed RNA polymerase II subunit RPB4 |
Schistosoma japonicum | Sjp_0061690 | ko:K03012 DNA-directed RNA polymerase II subunit D, putative |
Schistosoma mansoni | Smp_074230 | DNA-directed RNA polymerase II |
Schmidtea mediterranea | mk4.002007.01 | DNA-directed RNA polymerase II subunit RPB4 |
Toxoplasma gondii | TGME49_231380 | DNA-directed RNA polymerase II RPB4 |
Theileria parva | TP02_0359 | DNA-directed RNA polymerase II subunit Rpb4, putative |
Trichomonas vaginalis | TVAG_183050 | hypothetical protein |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
CELE_F43E2.2 | Caenorhabditis elegans | embryonic lethal | wormbase |
TGME49_231380 | Toxoplasma gondii | Probably essential | sidik |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.