Detailed view for BBOV_IV005930

Basic information

TDR Targets ID: 359276
Babesia bovis, aminopeptidase, putative
Source Database / ID: 

pI: 5.7511 | Length (AA): 846 | MW (Da): 95942 | Paralog Number: 0

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF01433   Peptidase family M1 domain
PF11940   Domain of unknown function (DUF3458) Ig-like fold
PF17432   Domain of unknown function (DUF3458_C) ARM repeats

Gene Ontology

Mouse over links to read term descriptions.
GO:0008237   metallopeptidase activity  
GO:0008270   zinc ion binding  
GO:0006508   proteolysis  

Metabolic Pathways

Glutathione metabolism (KEGG)
Global map (KEGG)

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
30 836 3b34 (A) 5 869 41.00 0 1 1.4218 -0.69
30 838 4x2u (A) 196 1084 38.00 0 1 1.37016 -0.65
33 837 5dll (A) 13 863 45.00 0 1 1.42904 -0.46

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_130542)

Species Accession Gene Product
Arabidopsis thaliana AT1G63770   peptidase M1 family protein
Babesia bovis BBOV_IV005930   aminopeptidase, putative
Cryptosporidium hominis Chro.80395   aminopeptidase N
Cryptosporidium parvum cgd8_3430   zincin/aminopeptidase N like metalloprotease
Escherichia coli b0932   aminopeptidase N
Neospora caninum NCLIV_048240   hypothetical protein
Neospora caninum NCLIV_048230   Aminopeptidase N (EC 3.4.11.2), related
Oryza sativa 4346337   Os08g0562700
Plasmodium berghei PBANKA_1410300   M1-family alanyl aminopeptidase, putative
Plasmodium falciparum PF3D7_1311800   M1-family alanyl aminopeptidase
Plasmodium knowlesi PKNH_1412500   M1-family alanyl aminopeptidase, putative
Plasmodium vivax PVX_122425   M1-family alanyl aminopeptidase, putative
Plasmodium yoelii PY01557   m1-family aminopeptidase
Toxoplasma gondii TGME49_224460   aminopeptidase n, putative
Toxoplasma gondii TGME49_221310   aminopeptidase N protein
Toxoplasma gondii TGME49_224350   aminopeptidase N, putative
Theileria parva TP01_0397   alpha-aminoacylpeptide hydrolase, putative

Essentiality

BBOV_IV005930 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
b0932 Escherichia coli non-essential goodall
PBANKA_1410300 Plasmodium berghei Essential plasmo
TGME49_221310 Toxoplasma gondii Essentiality uncertain sidik
TGME49_224350 Toxoplasma gondii Essentiality uncertain sidik
TGME49_224460 Toxoplasma gondii Essentiality uncertain sidik
TGME49_221310 Toxoplasma gondii Probably non-essential sidik
TGME49_224350 Toxoplasma gondii Probably non-essential sidik
TGME49_224460 Toxoplasma gondii Probably non-essential sidik
Show/Hide essentiality data references
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Plasmodium falciparum 3D7 M1-family aminopeptidase Compounds References
Plasmodium falciparum FcB1/Columbia Zinc aminopeptidase Compounds References
Plasmodium falciparum M1-family alanyl aminopeptidase Compounds References
Escherichia coli aminopeptidase N Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

No user comments are available for this gene. Log in to add comments, or register.

Enter your comment

User ()
Gene identifier BBOV_IV005930 (Babesia bovis), aminopeptidase, putative
Title for this comment
Comment