pI: 9.5633 |
Length (AA): 924 |
MW (Da): 104713 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 7 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
13 | 241 | 3jvu (B) | 44 | 301 | 17.00 | 0.0000061 | 0.93 | 0.284335 | 0.37 |
38 | 120 | 5e7p (A) | 219 | 295 | 30.00 | 0.096 | 0.62 | 0.391627 | -0.15 |
69 | 780 | 5iw7 (A) | 68 | 787 | 17.00 | 0 | 1 | 0.653063 | 1.38 |
78 | 114 | 2vp0 (A) | 13 | 49 | 32.00 | 0 | 0.23 | 0.268743 | 0.79 |
86 | 238 | 5dn8 (A) | 176 | 344 | 20.00 | 0.0008 | 1 | 0.417084 | -0.71 |
831 | 905 | 5j2l (B) | 1 | 76 | 24.00 | 0.24 | 0.02 | 0.405669 | -1.12 |
853 | 922 | 5hmo (A) | 802 | 871 | 20.00 | 0.000031 | 0 | 0.331258 | -0.75 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_127790)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT1G06720 | BMS1 domain-containing protein |
Babesia bovis | BBOV_III003460 | conserved hypothetical protein |
Brugia malayi | Bm1_52810 | Ribosome biogenesis protein BMS1 homolog |
Candida albicans | CaO19.2504 | bud site selection |
Candida albicans | CaO19.10040 | bud site selection |
Caenorhabditis elegans | CELE_Y61A9LA.10 | Protein Y61A9LA.10 |
Cryptosporidium hominis | Chro.40168 | hypothetical protein |
Cryptosporidium hominis | Chro.40169 | hypothetical protein |
Cryptosporidium parvum | cgd4_1480 | BMS1 like GTpase involved in ribosome biogenesis |
Dictyostelium discoideum | DDB_G0287891 | BMS1-like ribosome biogenesis protein |
Drosophila melanogaster | Dmel_CG7728 | CG7728 gene product from transcript CG7728-RA |
Echinococcus granulosus | EgrG_000954800 | ribosome biogenesis protein BMS1 |
Entamoeba histolytica | EHI_196410 | Ribosome biogenesis protein BMS1, putative |
Echinococcus multilocularis | EmuJ_000954800 | ribosome biogenesis protein BMS1 |
Giardia lamblia | GL50803_102722 | Ribosome biogenesis protein BMS1 |
Homo sapiens | ENSG00000165733 | BMS1 ribosome biogenesis factor |
Homo sapiens | 102724031 | ribosome biogenesis protein BMS1 homolog |
Homo sapiens | 101929959 | ribosome biogenesis protein BMS1 homolog |
Homo sapiens | 102725365 | ribosome biogenesis protein BMS1 homolog |
Leishmania braziliensis | LbrM.28.2050 | hypothetical protein, conserved |
Leishmania donovani | LdBPK_282000.1 | AARP2CN (NUC121) domain/Protein of unknown function (DUF663), putative |
Leishmania infantum | LinJ.28.2000 | hypothetical protein, conserved |
Leishmania major | LmjF.28.1880 | hypothetical protein, conserved |
Leishmania mexicana | LmxM.28.1880 | hypothetical protein, conserved |
Loa Loa (eye worm) | LOAG_06959 | Bms1l protein |
Mus musculus | ensembl-mmu:ENSMUSG00000030138 | BMS1 homolog, ribosome assembly protein (yeast) |
Neospora caninum | NCLIV_057070 | ribosome biogenesis protein BMS1, putative |
Oryza sativa | 4332742 | Os03g0333100 |
Onchocerca volvulus | OVOC6701 |
|
Plasmodium berghei | PBANKA_0206600 | asparagine and aspartate rich protein 2, putative |
Plasmodium falciparum | PF3D7_0106700 | small ribosomal subunit assembling AARP2 protein |
Plasmodium knowlesi | PKNH_0206800 | aarp2 protein, putative |
Plasmodium vivax | PVX_081435 | ribosome biogenesis protein BMS1, putative |
Plasmodium yoelii | PY04551 | hypothetical protein |
Saccharomyces cerevisiae | YPL217C | GTPase BMS1 |
Schistosoma japonicum | Sjp_0051420 | expressed protein |
Schistosoma japonicum | Sjp_0051430 | Ribosome biogenesis protein BMS1 homolog, putative |
Schistosoma mansoni | Smp_100030 | ribosome biogenesis protein BMS1 |
Schmidtea mediterranea | mk4.007429.01 | Bms1l protein |
Schmidtea mediterranea | mk4.003438.02 | Bms1l protein |
Trypanosoma brucei gambiense | Tbg972.11.10140 | hypothetical protein, conserved |
Trypanosoma brucei | Tb927.11.9080 | AARP2CN (NUC121) domain/Protein of unknown function (DUF663), putative |
Trypanosoma congolense | TcIL3000.11.9430 | AARP2CN (NUC121) domain/Protein of unknown function (DUF663), putative |
Trypanosoma cruzi | TcCLB.466879.10 | AARP2CN (NUC121) domain/Protein of unknown function (DUF663), putative |
Trypanosoma cruzi | TcCLB.510901.10 | AARP2CN (NUC121) domain/Protein of unknown function (DUF663), putative |
Trypanosoma cruzi | TcCLB.510899.59 | AARP2CN (NUC121) domain/Protein of unknown function (DUF663), putative |
Trypanosoma cruzi | TcCLB.511799.9 | AARP2CN (NUC121) domain/Protein of unknown function (DUF663), putative |
Trypanosoma cruzi | TcCLB.507077.9 | AARP2CN (NUC121) domain/Protein of unknown function (DUF663), putative |
Toxoplasma gondii | TGME49_313830 | AARP2CN (NUC121) domain-containing protein |
Theileria parva | TP03_0061 | hypothetical protein, conserved |
Theileria parva | TP03_0062 | hypothetical protein, conserved |
Trichomonas vaginalis | TVAG_296690 | ribosome biogenesis protein, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb11.01.0820 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb11.01.0820 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb11.01.0820 | Trypanosoma brucei | significant loss of fitness in procyclic forms | alsford |
Tb11.01.0820 | Trypanosoma brucei | no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
CELE_Y61A9LA.10 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_Y61A9LA.10 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_Y61A9LA.10 | Caenorhabditis elegans | slow growth | wormbase |
CELE_Y61A9LA.10 | Caenorhabditis elegans | sterile | wormbase |
YPL217C | Saccharomyces cerevisiae | inviable | yeastgenome |
PBANKA_0206600 | Plasmodium berghei | Essential | plasmo |
TGME49_313830 | Toxoplasma gondii | Probably essential | sidik |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.