Detailed view for BBOV_IV001160

Basic information

TDR Targets ID: 360277
Babesia bovis, chromatin assembly factor 1 subunit C, putative
Source Database / ID: 

pI: 4.304 | Length (AA): 400 | MW (Da): 44717 | Paralog Number: 1

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00400   WD domain, G-beta repeat
PF12265   Histone-binding protein RBBP4 or subunit C of CAF1 complex

Gene Ontology

Mouse over links to read term descriptions.
GO:0005515   protein binding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1 393 3cfs (B) 16 410 28.00 0 1 1.1879 -0.05
129 189 3fm0 (A) 164 221 40.00 0.99 0.39 0.4379 0.24
161 223 4g56 (B) 244 309 29.00 0.37 0.88 0.4849 0.01
165 320 1p22 (A) 308 458 23.00 0.061 1 0.7054 -0.35

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_127148)

Species Accession Gene Product
Arabidopsis thaliana AT4G35050   WD-40 repeat-containing protein MSI3
Arabidopsis thaliana AT2G16780   WD-40 repeat-containing protein MSI2
Arabidopsis thaliana AT5G58230   histone-binding protein MSI1
Babesia bovis BBOV_IV011040   retinoblastoma A associated protein, putative
Babesia bovis BBOV_IV001160   chromatin assembly factor 1 subunit C, putative
Brugia malayi Bm1_57630   retinoblastoma-binding protein.
Candida albicans CaO19.9693   WD40 repeat protein similar to S. cerevisiae HAT2 (YEL056W) histone acetyltransferase subunit 2
Candida albicans CaO19.2146   WD40 repeat protein similar to S. cerevisiae HAT2 (YEL056W) histone acetyltransferase subunit 2
Caenorhabditis elegans CELE_K07A1.12   Protein LIN-53
Caenorhabditis elegans CELE_K07A1.11   Protein RBA-1
Cryptosporidium hominis Chro.50316   ENSANGP00000014714
Cryptosporidium hominis Chro.10221   WD-40 repeat protein MSI1
Cryptosporidium parvum cgd1_1930   WD40 repeat protein, predicted histone deacetylase subunit
Cryptosporidium parvum cgd5_740   WD repeat protein
Dictyostelium discoideum DDB_G0282529   WD-40 repeat-containing protein
Drosophila melanogaster Dmel_CG4236   Chromatin assembly factor 1 subunit
Echinococcus granulosus EgrG_000611800   histone binding protein Caf1
Echinococcus granulosus EgrG_000088600   retinoblastoma binding protein 4
Entamoeba histolytica EHI_020290   WD domain containing protein
Echinococcus multilocularis EmuJ_000611800   histone binding protein Caf1
Echinococcus multilocularis EmuJ_000088600   retinoblastoma binding protein 4
Giardia lamblia GL50803_14753   Histone acetyltransferase type B subunit 2
Homo sapiens ENSG00000162521   retinoblastoma binding protein 4
Homo sapiens ENSG00000102054   retinoblastoma binding protein 7
Leishmania braziliensis LbrM.30.1070   hypothetical protein, conserved
Leishmania donovani LdBPK_301010.1   Histone-binding protein RBBP4 or subunit C of CAF1 complex/WD domain, G-beta repeat, putative
Leishmania infantum LinJ.30.1010   hypothetical protein, conserved
Leishmania major LmjF.30.0950   hypothetical protein, conserved
Leishmania mexicana LmxM.29.0950   hypothetical protein, conserved
Loa Loa (eye worm) LOAG_03438   retinoblastoma-binding protein
Mus musculus ENSMUSG00000031353   retinoblastoma binding protein 7
Mus musculus ENSMUSG00000057236   retinoblastoma binding protein 4
Neospora caninum NCLIV_040370   hypothetical protein
Neospora caninum NCLIV_067740   Probable histone-binding protein rba-1, related
Neospora caninum NCLIV_063770   hypothetical protein
Oryza sativa 4347727   Os09g0540600
Oryza sativa 4333540   Os03g0640100
Plasmodium berghei PBANKA_1344300   chromatin assembly factor 1 subunit, putative
Plasmodium berghei PBANKA_0203000   chromatin assembly factor 1 protein WD40 domain, putative
Plasmodium berghei PBANKA_1011600   chromatin assembly factor 1 P55 subunit, putative
Plasmodium falciparum PF3D7_1329300   chromatin assembly factor 1 subunit, putative
Plasmodium falciparum PF3D7_1433300   chromatin assembly factor 1 P55 subunit, putative
Plasmodium falciparum PF3D7_0110700   chromatin assembly factor 1 protein WD40 domain, putative
Plasmodium knowlesi PKNH_1271100   chromatin assembly factor 1 subunit, putative
Plasmodium knowlesi PKNH_0203200   chromatin assembly factor 1 protein WD40 domain, putative
Plasmodium knowlesi PKNH_0419900   chromatin assembly factor 1 P55 subunit, putative
Plasmodium vivax PVX_082410   chromatin assembly factor 1 P55 subunit, putative
Plasmodium vivax PVX_081265   chromatin assembly factor 1 protein WD40 domain, putative
Plasmodium vivax PVX_084870   chromatin assembly factor 1 P55 subunit, putative
Plasmodium yoelii PY01043   wd-40 repeat protein msi1
Plasmodium yoelii PY02400   wd-40 repeat protein msi1
Plasmodium yoelii PY05679   wd-40 repeat protein msi3
Saccharomyces cerevisiae YEL056W   Hat2p
Schistosoma japonicum Sjp_0212330   Probable histone-binding protein Caf1, putative
Schistosoma japonicum Sjp_0061700   ko:K10752 chromatin assembly factor 1 subunit C, putative
Schistosoma mansoni Smp_068950   retinoblastoma-binding protein 4 (rbbp4)
Schmidtea mediterranea mk4.017702.00  
Schmidtea mediterranea mk4.000231.06  
Schmidtea mediterranea mk4.008518.00  
Schmidtea mediterranea mk4.005619.00   Probable histone-binding protein Caf1
Schmidtea mediterranea mk4.024679.00   Probable histone-binding protein Caf1
Schmidtea mediterranea mk4.001359.00  
Schmidtea mediterranea mk4.007252.02   Probable histone-binding protein Caf1
Schmidtea mediterranea mk4.006950.01  
Schmidtea mediterranea mk4.000447.06   Probable histone-binding protein Caf1
Schmidtea mediterranea mk4.001420.00  
Schmidtea mediterranea mk4.028593.00   Probable histone-binding protein Caf1
Schmidtea mediterranea mk4.006661.00   Probable histone-binding protein Caf1
Schmidtea mediterranea mk4.001000.00  
Schmidtea mediterranea mk4.008177.00  
Schmidtea mediterranea mk4.002813.04  
Schmidtea mediterranea mk4.000101.20  
Schmidtea mediterranea mk4.011858.00  
Schmidtea mediterranea mk4.024301.00  
Schmidtea mediterranea mk4.009810.01  
Schmidtea mediterranea mk4.025138.01  
Schmidtea mediterranea mk4.001400.02  
Schmidtea mediterranea mk4.007036.00  
Schmidtea mediterranea mk4.018228.00   Probable histone-binding protein Caf1
Schmidtea mediterranea mk4.000025.06   Retinoblastoma binding protein-1
Schmidtea mediterranea mk4.008934.07  
Schmidtea mediterranea mk4.013436.02  
Schmidtea mediterranea mk4.002211.00   Probable histone-binding protein Caf1
Schmidtea mediterranea mk4.001495.04  
Schmidtea mediterranea mk4.017042.01  
Schmidtea mediterranea mk4.030169.00   Probable histone-binding protein Caf1
Schmidtea mediterranea mk4.000539.02   Probable histone-binding protein Caf1
Schmidtea mediterranea mk4.028401.02  
Schmidtea mediterranea mk4.013076.00   Probable histone-binding protein Caf1
Schmidtea mediterranea mk4.023448.00   Probable histone-binding protein Caf1
Schmidtea mediterranea mk4.000093.01  
Schmidtea mediterranea mk4.021499.00  
Schmidtea mediterranea mk4.000405.03   Probable histone-binding protein Caf1
Schmidtea mediterranea mk4.000090.13   Probable histone-binding protein rba-1
Schmidtea mediterranea mk4.005233.00  
Schmidtea mediterranea mk4.041447.00   Probable histone-binding protein Caf1
Schmidtea mediterranea mk4.000796.02  
Schmidtea mediterranea mk4.012992.00  
Schmidtea mediterranea mk4.003567.00   Probable histone-binding protein Caf1
Schmidtea mediterranea mk4.007957.04  
Schmidtea mediterranea mk4.022233.00   Probable histone-binding protein Caf1
Schmidtea mediterranea mk4.015850.01  
Schmidtea mediterranea mk4.006458.00  
Schmidtea mediterranea mk4.002285.06   Probable histone-binding protein Caf1
Schmidtea mediterranea mk4.009969.00  
Schmidtea mediterranea mk4.007632.00  
Schmidtea mediterranea mk4.004711.01  
Schmidtea mediterranea mk4.000508.01  
Schmidtea mediterranea mk4.001582.11  
Schmidtea mediterranea mk4.002775.01  
Schmidtea mediterranea mk4.004565.03   Probable histone-binding protein Caf1
Schmidtea mediterranea mk4.000025.17   Probable histone-binding protein Caf1
Schmidtea mediterranea mk4.020868.01  
Schmidtea mediterranea mk4.004663.03  
Schmidtea mediterranea mk4.008343.00  
Schmidtea mediterranea mk4.004811.01  
Schmidtea mediterranea mk4.004187.05  
Schmidtea mediterranea mk4.001340.01  
Schmidtea mediterranea mk4.037372.00   Probable histone-binding protein Caf1
Schmidtea mediterranea mk4.029668.00   Probable histone-binding protein Caf1
Schmidtea mediterranea mk4.039792.00  
Schmidtea mediterranea mk4.009249.01  
Schmidtea mediterranea mk4.025754.01   Probable histone-binding protein Caf1
Schmidtea mediterranea mk4.000044.03  
Schmidtea mediterranea mk4.006040.01  
Schmidtea mediterranea mk4.014067.01  
Schmidtea mediterranea mk4.010874.01   Probable histone-binding protein Caf1
Schmidtea mediterranea mk4.000080.01  
Schmidtea mediterranea mk4.006403.00  
Schmidtea mediterranea mk4.028595.02  
Schmidtea mediterranea mk4.004855.01  
Schmidtea mediterranea mk4.004054.09  
Schmidtea mediterranea mk4.009243.02  
Schmidtea mediterranea mk4.007468.00   Probable histone-binding protein Caf1
Schmidtea mediterranea mk4.000509.03  
Schmidtea mediterranea mk4.013621.00  
Schmidtea mediterranea mk4.004319.05  
Schmidtea mediterranea mk4.007065.01   Probable histone-binding protein Caf1
Schmidtea mediterranea mk4.012058.00   Probable histone-binding protein Caf1
Schmidtea mediterranea mk4.028498.01  
Schmidtea mediterranea mk4.000460.04   Probable histone-binding protein Caf1
Schmidtea mediterranea mk4.003404.00  
Schmidtea mediterranea mk4.005763.00  
Schmidtea mediterranea mk4.000743.00  
Schmidtea mediterranea mk4.001209.04   Probable histone-binding protein Caf1
Schmidtea mediterranea mk4.020871.00  
Schmidtea mediterranea mk4.000810.08   RBBP4-1
Schmidtea mediterranea mk4.027041.00  
Schmidtea mediterranea mk4.015986.00  
Schmidtea mediterranea mk4.016323.01  
Schmidtea mediterranea mk4.020414.00  
Schmidtea mediterranea mk4.021167.02  
Schmidtea mediterranea mk4.011253.00  
Schmidtea mediterranea mk4.018389.00  
Schmidtea mediterranea mk4.002025.00   Probable histone-binding protein Caf1
Schmidtea mediterranea mk4.000378.02  
Schmidtea mediterranea mk4.003067.04  
Schmidtea mediterranea mk4.005704.01  
Schmidtea mediterranea mk4.051955.01  
Schmidtea mediterranea mk4.030081.00  
Schmidtea mediterranea mk4.006557.00  
Schmidtea mediterranea mk4.001502.01   Probable histone-binding protein Caf1
Schmidtea mediterranea mk4.006957.02  
Schmidtea mediterranea mk4.008354.00  
Schmidtea mediterranea mk4.011644.00   Probable histone-binding protein Caf1
Schmidtea mediterranea mk4.000827.02  
Schmidtea mediterranea mk4.002590.00  
Schmidtea mediterranea mk4.001411.06  
Schmidtea mediterranea mk4.010482.06  
Schmidtea mediterranea mk4.000661.13  
Schmidtea mediterranea mk4.000509.02  
Schmidtea mediterranea mk4.016365.01  
Schmidtea mediterranea mk4.001796.00  
Schmidtea mediterranea mk4.003037.06   Probable histone-binding protein Caf1
Schmidtea mediterranea mk4.002386.05  
Schmidtea mediterranea mk4.023363.00  
Schmidtea mediterranea mk4.004195.08  
Schmidtea mediterranea mk4.004779.00  
Schmidtea mediterranea mk4.001723.02   Probable histone-binding protein Caf1
Schmidtea mediterranea mk4.016340.01  
Schmidtea mediterranea mk4.010735.00  
Toxoplasma gondii TGME49_278280   WD domain, G-beta repeat-containing protein
Toxoplasma gondii TGME49_264820   RbAp48
Toxoplasma gondii TGME49_247250   RbAp46
Theileria parva TP01_0772   chromatin assembly factor 1 subunit, putative
Theileria parva TP01_0142   hypothetical protein

Essentiality

BBOV_IV001160 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_K07A1.12 Caenorhabditis elegans embryonic arrest wormbase
CELE_K07A1.12 Caenorhabditis elegans embryonic lethal wormbase
CELE_K07A1.12 Caenorhabditis elegans larval lethal wormbase
CELE_K07A1.11 Caenorhabditis elegans embryonic arrest wormbase
CELE_K07A1.11 Caenorhabditis elegans embryonic lethal wormbase
PBANKA_0203000 Plasmodium berghei Slow plasmo
PBANKA_1011600 Plasmodium berghei Slow plasmo
PBANKA_1344300 Plasmodium berghei Essential plasmo
TGME49_264820 Toxoplasma gondii Probably essential sidik
TGME49_247250 Toxoplasma gondii Probably essential sidik
TGME49_278280 Toxoplasma gondii Probably essential sidik
TGME49_264820 Toxoplasma gondii Essentiality uncertain sidik
TGME49_247250 Toxoplasma gondii Essentiality uncertain sidik
TGME49_278280 Toxoplasma gondii Essentiality uncertain sidik
Show/Hide essentiality data references
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens retinoblastoma binding protein 7 Compounds References
Homo sapiens retinoblastoma binding protein 4 Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier BBOV_IV001160 (Babesia bovis), chromatin assembly factor 1 subunit C, putative
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