Detailed view for Chro.50146

Basic information

TDR Targets ID: 364843
Cryptosporidium hominis, ARP1 actin-related protein 1 A, centractin alpha
Source Database / ID: 

pI: 6.4144 | Length (AA): 395 | MW (Da): 43676 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00022   Actin

Gene Ontology

Mouse over links to read term descriptions.
GO:0005869   dynactin complex  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
8 395 4b1y (B) 1 375 51.00 0 1 1.59188 -0.9
12 392 4cbx (A) 5 373 49.00 0 1 1.54616 -0.82
13 387 4cbu (A) 7 368 51.00 0 1 1.58467 -0.96

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_129186)

Species Accession Gene Product
Brugia malayi Bm1_46920   Beta-centractin
Candida albicans CaO19.10164   actin-related protein of the dynactin complex
Candida albicans CaO19.2641   actin-related protein of the dynactin complex
Caenorhabditis elegans CELE_Y53F4B.22   Protein ARP-1
Cryptosporidium hominis Chro.50146   ARP1 actin-related protein 1 A, centractin alpha
Cryptosporidium parvum cgd5_2330   actin-like
Dictyostelium discoideum DDB_G0288937   actin related protein 1
Drosophila melanogaster Dmel_CG6174   Actin-related protein 1
Echinococcus granulosus EgrG_000994000   beta centractin
Echinococcus multilocularis EmuJ_000994000   beta centractin
Homo sapiens ENSG00000115073   ARP1 actin-related protein 1 homolog B, centractin beta (yeast)
Homo sapiens ENSG00000138107   ARP1 actin-related protein 1 homolog A, centractin alpha (yeast)
Loa Loa (eye worm) LOAG_07944   beta-centractin
Mus musculus ENSMUSG00000037351   ARP1 actin-related protein 1B, centractin beta
Mus musculus ENSMUSG00000025228   ARP1 actin-related protein 1A, centractin alpha
Neospora caninum NCLIV_064780   actin, putative
Plasmodium berghei PBANKA_0209300   actin-related protein
Plasmodium falciparum PF3D7_0103800   actin-related protein
Plasmodium knowlesi PKNH_0209700   actin-related protein
Plasmodium vivax PVX_081570   actin-related protein
Plasmodium yoelii PY04148   actin 3
Saccharomyces cerevisiae YHR129C   actin-related protein 1
Schistosoma japonicum Sjp_0022150   Alpha-centractin, putative
Schistosoma mansoni Smp_072870   actin
Schmidtea mediterranea mk4.000656.13   Actin-related protein 1
Schmidtea mediterranea mk4.000195.00  
Toxoplasma gondii TGME49_248630   actin-related protein ARP1

Essentiality

Chro.50146 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_Y53F4B.22 Caenorhabditis elegans embryonic lethal wormbase
CELE_Y53F4B.22 Caenorhabditis elegans larval arrest wormbase
CELE_Y53F4B.22 Caenorhabditis elegans larval lethal wormbase
CELE_Y53F4B.22 Caenorhabditis elegans slow growth wormbase
YHR129C Saccharomyces cerevisiae inviable yeastgenome
TGME49_248630 Toxoplasma gondii Essentiality uncertain sidik
Show/Hide essentiality data references
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Xenopus laevis beta-actin 375 aa 50.4% 379 aa Compounds References
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Chro.50146 (Cryptosporidium hominis), ARP1 actin-related protein 1 A, centractin alpha
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