Detailed view for cgd5_820

Basic information

TDR Targets ID: 376752
Cryptosporidium parvum, calcium/calmodulin dependent protein kinase with a kinase domain and 4 calmodulin like EF hands
Source Database / ID: 

pI: 6.2216 | Length (AA): 523 | MW (Da): 59759 | Paralog Number: 3

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00069   Protein kinase domain
PF13499   EF-hand domain pair

Gene Ontology

Mouse over links to read term descriptions.
GO:0005524   ATP binding  
GO:0005509   calcium ion binding  
GO:0004672   protein kinase activity  
GO:0006468   protein amino acid phosphorylation  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
6 325 4tnd (A) 130 455 20.00 0 1 0.809255 0.05
40 516 3lij (A) 40 516 99.99 0 1 2.09325 -1.32
447 512 2m97 (A) 1 68 33.00 0 1 0.694595 -2.41

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

PDB tag
  • 3L19:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date
PDB tag
  • 3LIJ:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_126600)

Species Accession Gene Product
Arabidopsis thaliana AT1G18890   calcium-dependent protein kinase 1
Arabidopsis thaliana AT2G38910   calcium-dependent protein kinase 20
Arabidopsis thaliana AT2G35890   calcium-dependent protein kinase 25
Arabidopsis thaliana AT1G35670   calcium-dependent protein kinase 2
Arabidopsis thaliana AT4G04710   calcium-dependent protein kinase 22
Arabidopsis thaliana AT1G50700   calcium-dependent protein kinase 33
Arabidopsis thaliana AT5G23580   calcium-dependent protein kinase 12
Arabidopsis thaliana AT5G04870   calcium dependent protein kinase 1
Arabidopsis thaliana AT1G74740   calcium-dependent protein kinase 30
Arabidopsis thaliana AT4G04740   calcium-dependent protein kinase 23
Arabidopsis thaliana AT3G10660   Ccalcium-dependent protein kinase 2
Arabidopsis thaliana AT3G51850   calcium-dependent protein kinase 13
Arabidopsis thaliana AT1G61950   calcium-dependent protein kinase 19
Arabidopsis thaliana AT4G04695   calcium-dependent protein kinase 31
Arabidopsis thaliana AT5G12480   calmodulin-domain protein kinase 7
Arabidopsis thaliana AT4G09570   calcium-dependent protein kinase 4
Arabidopsis thaliana AT4G38230   calcium-dependent protein kinase 26
Arabidopsis thaliana AT5G12180   calcium-dependent protein kinase 17
Arabidopsis thaliana AT4G23650   calcium-dependent protein kinase 6
Arabidopsis thaliana AT4G04720   calcium-dependent protein kinase 21
Arabidopsis thaliana AT5G19360   calcium-dependent protein kinase 34
Arabidopsis thaliana AT2G17290   calcium dependent protein kinase 6
Arabidopsis thaliana AT2G31500   calcium-dependent protein kinase 24
Arabidopsis thaliana AT4G21940   calcium-dependent protein kinase 15
Arabidopsis thaliana AT3G57530   calcium-dependent protein kinase 32
Arabidopsis thaliana AT3G20410   calmodulin-domain protein kinase 9
Arabidopsis thaliana AT4G35310   calmodulin-domain protein kinase 5
Arabidopsis thaliana AT4G04700   calcium-dependent protein kinase 27
Arabidopsis thaliana AT5G19450   calcium-dependent protein kinase 19
Arabidopsis thaliana AT2G41860   calcium-dependent protein kinase 14
Babesia bovis BBOV_IV003210   calcium-dependent protein kinase 4
Babesia bovis BBOV_III005470   protein kinase domain containing protein
Brugia malayi Bm1_37225   Calcium/calmodulin-dependent protein kinase type II alpha chain
Brugia malayi Bm1_31570   Cam kinase protein 1
Candida albicans CaO19.9323   Serine-threonine protein kinase similar to S. cerevisiae CMK2 (YOL016C) calcium/calmodulin-dependent protein kinase
Candida albicans CaO19.1754   Serine-threonine protein kinase similar to S. cerevisiae CMK2 (YOL016C) calcium/calmodulin-dependent protein kinase
Caenorhabditis elegans CELE_K11E8.1   Protein UNC-43, isoform R
Caenorhabditis elegans CELE_K07A9.2   Protein CMK-1
Caenorhabditis elegans CELE_K11E8.7   Protein UNC-43, isoform F
Cryptosporidium hominis Chro.20118   CDPK2
Cryptosporidium hominis Chro.50305   calmodulin-domain protein kinase 1
Cryptosporidium hominis Chro.20142   calcium-dependent protein kinase
Cryptosporidium hominis Chro.30121   hypothetical protein
Cryptosporidium parvum cgd2_1060   calcium/calmodulin dependent protein kinase with a kinas domain and 4 calmodulin-like EF hands
Cryptosporidium parvum cgd5_820   calcium/calmodulin dependent protein kinase with a kinase domain and 4 calmodulin like EF hands
Cryptosporidium parvum cgd2_1300   calcium/calmodulin dependent protein kinase with a kinase domain and 4 calmodulin like EF hands
Cryptosporidium parvum cgd3_920   calmodulin-domain protein kinase 1, putative
Dictyostelium discoideum DDB_G0292624   CAMK1 family protein kinase
Dictyostelium discoideum DDB_G0289119   CAMK1 family protein kinase
Dictyostelium discoideum DDB_G0275057   CAMK1 family protein kinase
Dictyostelium discoideum DDB_G0282429   CAMK1 family protein kinase
Dictyostelium discoideum DDB_G0271550   CAMK1 family protein kinase
Dictyostelium discoideum DDB_G0279925   CAM kinase
Drosophila melanogaster Dmel_CG1495   Calcium/calmodulin-dependent protein kinase I
Drosophila melanogaster Dmel_CG18069   Calcium/calmodulin-dependent protein kinase II
Echinococcus granulosus EgrG_000809000   calcium:calmodulin dependent protein kinase type
Echinococcus granulosus EgrG_000595500   calcium:calmodulin dependent protein kinase type
Echinococcus granulosus EgrG_000438300   calcium dependent protein kinase
Echinococcus granulosus EgrG_001083300   calcium:calmodulin dependent protein kinase type
Echinococcus granulosus EgrG_000826600   calcium:calmodulin dependent protein kinase type 1
Entamoeba histolytica EHI_137980   protein kinase, putative
Entamoeba histolytica EHI_053060   protein kinase, putative
Echinococcus multilocularis EmuJ_001083300   calcium:calmodulin dependent protein kinase type
Echinococcus multilocularis EmuJ_000826600   calcium:calmodulin dependent protein kinase type
Echinococcus multilocularis EmuJ_000595500   calcium:calmodulin dependent protein kinase type
Echinococcus multilocularis EmuJ_000438300   calcium dependent protein kinase
Echinococcus multilocularis EmuJ_000809000   calcium:calmodulin dependent protein kinase type
Homo sapiens ENSG00000145349   calcium/calmodulin-dependent protein kinase II delta
Homo sapiens ENSG00000008118   calcium/calmodulin-dependent protein kinase IG
Homo sapiens ENSG00000148660   calcium/calmodulin-dependent protein kinase II gamma
Homo sapiens ENSG00000058404   calcium/calmodulin-dependent protein kinase II beta
Homo sapiens ENSG00000134072   calcium/calmodulin-dependent protein kinase I
Homo sapiens ENSG00000183049   calcium/calmodulin-dependent protein kinase ID
Homo sapiens ENSG00000130822   pregnancy up-regulated nonubiquitous CaM kinase
Homo sapiens ENSG00000070808   calcium/calmodulin-dependent protein kinase II alpha
Homo sapiens 814   calcium/calmodulin-dependent protein kinase IV
Leishmania braziliensis LbrM.27.2680   protein kinase, putative
Leishmania donovani LdBPK_272420.1   protein kinase, putative
Leishmania infantum LinJ.27.2420   protein kinase, putative
Leishmania major LmjF.27.2470   protein kinase, putative
Leishmania mexicana LmxM.27.2470   protein kinase, putative
Loa Loa (eye worm) LOAG_08089   calcium/calmodulin-dependent protein kinase ID
Loa Loa (eye worm) LOAG_00568   CAMK/CAMK2 protein kinase
Loa Loa (eye worm) LOAG_13538   hypothetical protein
Mus musculus ENSMUSG00000016179   calcium/calmodulin-dependent protein kinase I gamma
Mus musculus ENSMUSG00000002012   pregnancy upregulated non-ubiquitously expressed CaM kinase
Mus musculus ENSMUSG00000021820   calcium/calmodulin-dependent protein kinase II gamma
Mus musculus ENSMUSG00000057897   calcium/calmodulin-dependent protein kinase II, beta
Mus musculus ENSMUSG00000024617   calcium/calmodulin-dependent protein kinase II alpha
Mus musculus ENSMUSG00000030272   calcium/calmodulin-dependent protein kinase I
Mus musculus ENSMUSG00000038128   calcium/calmodulin-dependent protein kinase IV
Mus musculus ENSMUSG00000053819   calcium/calmodulin-dependent protein kinase II, delta
Mus musculus ENSMUSG00000039145   calcium/calmodulin-dependent protein kinase ID
Mus musculus 102642817   calcium/calmodulin-dependent protein kinase type I-like
Neospora caninum NCLIV_070280   hypothetical protein
Neospora caninum NCLIV_017560   Calcium-dependent protein kinase 2, related
Neospora caninum NCLIV_044270   hypothetical protein
Neospora caninum NCLIV_011980   Calmodulin-like domain protein kinase isoenzyme gamma, related
Neospora caninum NCLIV_047750   hypothetical protein
Oryza sativa 4336653   Os04g0560600
Oryza sativa 4334371   Os03g0789000
Oryza sativa 4343644   Os07g0568600
Oryza sativa 4349249   Os10g0539600
Oryza sativa 4351620   Os12g0169800
Oryza sativa 4339177   Os05g0491900
Oryza sativa 4349899   Os11g0171500
Oryza sativa 4339053   Os05g0467000
Oryza sativa 4330351   Os02g0685900
Oryza sativa 4326638   Os01g0622600
Oryza sativa 4327560   Os01g0808400
Oryza sativa 4349714   Os11g0136600
Oryza sativa 9266580   Os12g0133500
Oryza sativa 4334366   Os03g0788500
Oryza sativa 4347564   Os09g0514200
Oryza sativa 4339751   Os05g0585500
Oryza sativa 4352234   Os12g0486600
Oryza sativa 4336783   Os04g0584600
Oryza sativa 4342456   Os07g0161600
Oryza sativa 4333767   Os03g0688300
Oryza sativa 4351829   Os12g0230200
Oryza sativa 4334519   Os03g0808600
Oryza sativa 4331257   Os02g0832000
Oryza sativa 4327438   Os01g0832300
Oryza sativa 4331490   Os03g0128700
Oryza sativa 4346187   Os08g0540400
Oryza sativa 4343373   Os07g0515100
Plasmodium berghei PBANKA_0314200   calcium-dependent protein kinase 1
Plasmodium berghei PBANKA_0615200   calcium-dependent protein kinase 4
Plasmodium berghei PBANKA_0408200   calcium-dependent protein kinase 3
Plasmodium berghei PBANKA_1351500   calcium-dependent protein kinase 5
Plasmodium falciparum PF3D7_0310100   calcium-dependent protein kinase 3
Plasmodium falciparum PF3D7_0717500   calcium-dependent protein kinase 4
Plasmodium falciparum PF3D7_0217500   calcium-dependent protein kinase 1
Plasmodium falciparum PF3D7_1337800   calcium-dependent protein kinase 5
Plasmodium falciparum PF3D7_0610600   calcium-dependent protein kinase 2
Plasmodium knowlesi PKNH_0312500   calcium-dependent protein kinase 4, putative
Plasmodium knowlesi PKNH_0832600   calcium-dependent protein kinase 3, putative
Plasmodium knowlesi PKNH_1263500   calcium-dependent protein kinase 5, putative
Plasmodium knowlesi PKNH_0403400   calcium-dependent protein kinase 1, putative
Plasmodium vivax PVX_119610   calcium-dependent protein kinase 3, putative
Plasmodium vivax PVX_000555   calcium-dependent protein kinase 4, putative
Plasmodium vivax PVX_082820   calcium-dependent protein kinase, putative
Plasmodium vivax PVX_002665   calcium-dependent protein kinase 1, putative
Plasmodium yoelii PY03298   calmodulin-domain protein kinase
Plasmodium yoelii PY02109   Plasmodium falciparum CDPK2 protein
Plasmodium yoelii PY06394   calcium-dependent protein kinase-3
Plasmodium yoelii PY06527   calcium-dept. protein kinase
Saccharomyces cerevisiae YOL016C   Cmk2p
Saccharomyces cerevisiae YFR014C   Cmk1p
Schistosoma japonicum Sjp_0121020   Calcium/calmodulin-dependent protein kinase type II alpha chain, putative
Schistosoma japonicum Sjp_0005690   Calcium/calmodulin-dependent protein kinase type II beta chain, putative
Schistosoma japonicum Sjp_0216090   ko:K04515 calcium/calmodulin-dependent protein kinase (CaM kinase) II, putative
Schistosoma japonicum Sjp_0049570   Calcium/calmodulin-dependent protein kinase type 1, putative
Schistosoma japonicum Sjp_0308710   Calcium/calmodulin-dependent protein kinase type II delta chain, putative
Schistosoma japonicum Sjp_0049580   ko:K08794 calcium/calmodulin-dependent protein kinase I, putative
Schistosoma mansoni Smp_011660.1   protein kinase
Schistosoma mansoni Smp_011660.3   protein kinase
Schistosoma mansoni Smp_065290   serine/threonine protein kinase
Schistosoma mansoni Smp_011660.2   protein kinase
Schmidtea mediterranea mk4.005994.00   Putative calcium/calmodulin-dependent protein kinase
Schmidtea mediterranea mk4.013326.00  
Schmidtea mediterranea mk4.000319.01  
Schmidtea mediterranea mk4.004587.02  
Schmidtea mediterranea mk4.000319.00   Calcium/calmodulin-dependent protein kinase type II
Schmidtea mediterranea mk4.008112.00   Calcium/calmodulin-dependent protein kinase type II
Schmidtea mediterranea mk4.000395.03   Calcium/calmodulin-dependent protein kinase type II
Schmidtea mediterranea mk4.018615.00   Calcium/calmodulin-dependent protein kinase type II
Schmidtea mediterranea mk4.001941.02  
Trypanosoma brucei gambiense Tbg972.4.3820   protein kinase, putative
Trypanosoma brucei Tb927.4.3770   calcium/calmodulin-dependent protein kinase, putative
Trypanosoma congolense TcIL3000_0_56880   protein kinase, putative
Trypanosoma congolense TcIL3000_0_32980   protein kinase, putative
Toxoplasma gondii TGME49_206590   calcium-dependent protein kinase CDPK2A
Toxoplasma gondii TGME49_305860   calcium-dependent protein kinase CDPK3
Toxoplasma gondii TGME49_242400   calcium-dependent protein kinase CDPK2B
Theileria parva TP01_1073   calmodulin-domain protein kinase, putative
Theileria parva TP02_0399   calcium-dependent protein kinase, putative
Trichomonas vaginalis TVAG_418720   CAMK family protein kinase

Essentiality

cgd5_820 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.4.3770 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.4.3770 Trypanosoma brucei significant gain of fitness in bloodstream forms (6 days) alsford
Tb927.4.3770 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.4.3770 Trypanosoma brucei significant gain of fitness in differentiation of procyclic to bloodstream forms alsford
PBANKA_0314200 Plasmodium berghei Dispensable plasmo
PBANKA_0408200 Plasmodium berghei Dispensable plasmo
PBANKA_0615200 Plasmodium berghei Slow plasmo
PBANKA_1351500 Plasmodium berghei Essential plasmo
TGME49_206590 Toxoplasma gondii Probably essential sidik
TGME49_305860 Toxoplasma gondii Probably essential sidik
TGME49_242400 Toxoplasma gondii Probably essential sidik
TGME49_206590 Toxoplasma gondii Probably non-essential sidik
TGME49_305860 Toxoplasma gondii Probably non-essential sidik
TGME49_242400 Toxoplasma gondii Probably non-essential sidik
TGME49_206590 Toxoplasma gondii Essentiality uncertain sidik
TGME49_305860 Toxoplasma gondii Essentiality uncertain sidik
TGME49_242400 Toxoplasma gondii Essentiality uncertain sidik
Show/Hide essentiality data references
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens pregnancy up-regulated nonubiquitous CaM kinase Compounds References
Homo sapiens calcium/calmodulin-dependent protein kinase IV Compounds References
Homo sapiens calcium/calmodulin-dependent protein kinase IG Compounds References
Homo sapiens calcium/calmodulin-dependent protein kinase II delta Compounds References
Homo sapiens calcium/calmodulin-dependent protein kinase II beta Compounds References
Rattus norvegicus Ca2+/calmodulin-dependent protein kinase II (CaM kinase II) Compounds References
Toxoplasma gondii calcium-dependent protein kinase CDPK3 Compounds References
Plasmodium falciparum calcium-dependent protein kinase 1 Compounds References
Homo sapiens calcium/calmodulin-dependent protein kinase I Compounds References
Triticum aestivum Calcium dependent protein kinase Compounds References
Plasmodium falciparum (isolate 3D7) Calcium-dependent protein kinase 4 Compounds References
Homo sapiens calcium/calmodulin-dependent protein kinase II alpha Compounds References
Homo sapiens calcium/calmodulin-dependent protein kinase ID Compounds References
Zea mays CaM kinase I alpha Compounds References
Homo sapiens calcium/calmodulin-dependent protein kinase II gamma Compounds References
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Rattus norvegicus Cell division protein kinase 5 292 aa 28.2% 301 aa Compounds References
Schizosaccharomyces pombe 972h- Casein kinase II subunit alpha 332 aa 22.5% 302 aa Compounds References
Oryctolagus cuniculus Cyclin-dependent kinase 4 189 aa 31.2% 173 aa Compounds References
Bos taurus Calmodulin 149 aa 34.8% 155 aa Compounds References
Rattus norvegicus Serine/threonine-protein kinase pim-3 326 aa 30.1% 269 aa Compounds References
Rattus norvegicus Glycogen synthase kinase-3 beta 420 aa 24.5% 364 aa Compounds References
Rattus norvegicus Jak1 protein 210 aa 28.4% 169 aa Compounds References
Plasmodium falciparum (isolate 3D7) Cell division control protein 2 homolog 288 aa 32.6% 291 aa Compounds References
Patiria pectinifera Cdc2 300 aa 29.6% 304 aa Compounds References
Rattus norvegicus Mitogen-activated protein kinase 1 358 aa 27.8% 306 aa Compounds References
Bos taurus Glycogen synthase kinase-3 beta splice variant X1 419 aa 24.7% 364 aa Compounds References
Rattus norvegicus MAP kinase p38 alpha 360 aa 31.0% 310 aa Compounds References
Zea mays Casein kinase II alpha 332 aa 24.3% 309 aa Compounds References
Homo sapiens Cyclin-dependent kinase 1/cyclin B1 297 aa 31.2% 292 aa Compounds References
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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Gene identifier cgd5_820 (Cryptosporidium parvum), calcium/calmodulin dependent protein kinase with a kinase domain and 4 calmodulin like EF hands
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