Detailed view for TcCLB.510187.100

Basic information

TDR Targets ID: 39140
Trypanosoma cruzi, glucokinase
Source Database / ID:  TriTrypDB  GeneDB

pI: 8.4588 | Length (AA): 376 | MW (Da): 41582 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF02685   Glucokinase

Gene Ontology

Mouse over links to read term descriptions.
GO:0051156   glucose 6-phosphate metabolic process  
GO:0005536   glucose binding  
GO:0005524   ATP binding  
GO:0004340   glucokinase activity  
GO:0006096   glycolysis  

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
23 367 1sz2 (A) 3 317 20.00 0 1 1.13 -0.52
25 372 2gup (A) 3 288 14.00 0 1 0.86 0.06
1 367 5brh (A) 1 367 99.99 0 1 2.22026 -1.52

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

PDB tag
  • 2Q2R:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date
PDB tag
  • 5BRD:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date
PDB tag
  • 5BRE:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date
PDB tag
  • 5BRF:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date
PDB tag
  • 5BRH:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_138843)

Species Accession Gene Product
Dictyostelium discoideum DDB_G0281523   hypothetical protein
Leishmania braziliensis LbrM.35.2550   glucokinase
Leishmania donovani LdBPK_362450.1   glucokinase
Leishmania infantum LinJ.36.2450   glucokinase
Leishmania major LmjF.36.2320   glucokinase
Leishmania mexicana LmxM.36.2320   glucokinase 1-like protein
Trypanosoma cruzi TcCLB.510187.100   glucokinase
Trichomonas vaginalis TVAG_260790   glucokinase, putative
Trichomonas vaginalis TVAG_045010   glucokinase, putative
Trichomonas vaginalis TVAG_258370   glucokinase, putative
Trichomonas vaginalis TVAG_023840   conserved hypothetical protein
Trichomonas vaginalis TVAG_092750   glucokinase
Trichomonas vaginalis TVAG_282870   glucokinase, putative
Trichomonas vaginalis TVAG_397250   glucokinase, putative
Trichomonas vaginalis TVAG_204370   glucokinase, putative
Trichomonas vaginalis TVAG_188820   glucokinase, putative
Trichomonas vaginalis TVAG_336940   glucokinase, putative
Trichomonas vaginalis TVAG_071780   conserved hypothetical protein

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

  • Assay for Glucokinase (2.7.1.2 ) Sigma-Aldrich
  • Automatic link to known assays based on EC numbers.

Reagent availability

No reagent availability information for this target.

Bibliographic References

2 literature references were collected for this gene.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier TcCLB.510187.100 (Trypanosoma cruzi), glucokinase
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