Detailed view for TcCLB.503803.20

Basic information

TDR Targets ID: 39320
Trypanosoma cruzi, kinesin heavy chain, putative
Source Database / ID:  TriTrypDB  GeneDB

pI: 7.3211 | Length (AA): 230 | MW (Da): 25886 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG3

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

No Pfam domain information for this protein.

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
41 167 1y4c (A) 342 651 20.00 0.08 0.33 0.655774 -0.76
85 141 5djn (A) 370 430 33.00 0.47 0.05 0.517426 -0.4
119 198 3etw (A) 5 85 24.00 0.54 0.09 0.674426 -1.23

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Mid 40-60% percentile metacyclic. Smircich P
Upregulation Percent Ranking Stage Dataset
Lower 20-40% percentile epimastigote. Smircich P
Show/Hide expression data references
  • Smircich P Ribosome profiling reveals translation control as a key mechanism generating differential gene expression in Trypanosoma cruzi.

Orthologs

Ortholog group members (OG5_127646)

Species Accession Gene Product
Arabidopsis thaliana AT3G63480   ATP binding microtubule motor family protein
Brugia malayi Bm1_44440   Kinesin motor domain containing protein
Candida albicans CaO19.5265   kinesin motor domain protein similar to S. cerevisiae SMY1 (YKL079W) myosin binding protein involved in bud growth
Candida albicans CaO19.12730   kinesin motor domain protein similar to S. cerevisiae SMY1 (YKL079W) myosin binding protein involved in bud growth
Caenorhabditis elegans CELE_R05D3.7   Protein UNC-116
Cryptosporidium hominis Chro.60321   kinesin heavy chain
Cryptosporidium parvum cgd6_2790   kinesin heavy chain, putative
Dictyostelium discoideum DDB_G0280967   kinesin family member 3
Drosophila melanogaster Dmel_CG7765   Kinesin heavy chain
Echinococcus granulosus EgrG_001083000   Zinc finger DPH type
Echinococcus granulosus EgrG_001025000   kinesin heavy chain
Echinococcus granulosus EgrG_000716000   kinesin 1 heavy chain
Echinococcus multilocularis EmuJ_001025000   kinesin heavy chain
Echinococcus multilocularis EmuJ_001083000   Zinc finger, DPH type
Echinococcus multilocularis EmuJ_000716000   kinesin 1 heavy chain
Giardia lamblia GL50803_13825   Kinesin-1
Homo sapiens ENSG00000168280   kinesin family member 5C
Homo sapiens ENSG00000155980   kinesin family member 5A
Homo sapiens ENSG00000170759   kinesin family member 5B
Leishmania braziliensis LbrM.20.4870   kinesin heavy chain, putative
Leishmania donovani LdBPK_200700.1   kinesin heavy chain, putative
Leishmania infantum LinJ.20.0700   kinesin heavy chain, putative
Leishmania major LmjF.20.0640   kinesin heavy chain, putative
Leishmania mexicana LmxM.20.0640   kinesin heavy chain, putative
Loa Loa (eye worm) LOAG_04442   kinesin motor domain-containing protein
Mus musculus ENSMUSG00000026764   kinesin family member 5C
Mus musculus ENSMUSG00000006740   kinesin family member 5B
Mus musculus ENSMUSG00000074657   kinesin family member 5A
Neospora caninum NCLIV_013990   GA21186, related
Oryza sativa 4344521   Os08g0117000
Schistosoma japonicum Sjp_0300470   ko:K10396 kinesin family member 5, putative
Schistosoma mansoni Smp_001040   kinesin heavy chain
Schmidtea mediterranea mk4.002360.03  
Schmidtea mediterranea mk4.000637.05  
Schmidtea mediterranea mk4.012715.01  
Schmidtea mediterranea mk4.000139.09  
Schmidtea mediterranea mk4.015674.00  
Schmidtea mediterranea mk4.001074.00   Kinesin heavy chain
Schmidtea mediterranea mk4.012715.00   Kinesin heavy chain
Schmidtea mediterranea mk4.003721.00   DPH3 homolog
Schmidtea mediterranea mk4.013842.00  
Schmidtea mediterranea mk4.013842.01   Kinesin heavy chain
Schmidtea mediterranea mk4.002094.00  
Schmidtea mediterranea mk4.015674.01   Kinesin heavy chain
Schmidtea mediterranea mk4.013842.02   Kinesin heavy chain
Schmidtea mediterranea mk4.012715.02   Kinesin heavy chain
Schmidtea mediterranea mk4.001472.00  
Trypanosoma brucei gambiense Tbg972.1.650   kinesin heavy chain, putative
Trypanosoma brucei Tb927.1.1350   kinesin heavy chain, putative
Trypanosoma brucei Tb11.v5.0392   kinesin heavy chain, putative
Trypanosoma congolense TcIL3000_1_810   kinesin heavy chain, putative
Trypanosoma congolense TcIL3000_0_17770   kinesin heavy chain, putative
Trypanosoma cruzi TcCLB.506479.60   kinesin heavy chain, putative
Trypanosoma cruzi TcCLB.503803.20   kinesin heavy chain, putative
Toxoplasma gondii TGME49_286660   kinesin, putative

Essentiality

TcCLB.503803.20 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.1.1350 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.1.1350 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb927.1.1350 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.1.1350 Trypanosoma brucei significant gain of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_R05D3.7 Caenorhabditis elegans embryonic lethal wormbase
CELE_R05D3.7 Caenorhabditis elegans slow growth wormbase
TGME49_286660 Toxoplasma gondii Probably non-essential sidik
Show/Hide essentiality data references
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens kinesin family member 5B Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

  • Tcru001325AAA;
  • Type Source Notes
    soluble recombinant protein Structural Genomics for Pathogenic Protozoa (SGPP) Tcru001325; Recombinant protein: full-length; Source: T cruzi; kinesin heavy chain isoform 5c, probable-related ;

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier TcCLB.503803.20 (Trypanosoma cruzi), kinesin heavy chain, putative
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