Detailed view for PF3D7_1324200

Basic information

TDR Targets ID: 41
Plasmodium falciparum, micro-fibrillar-associated protein, putative
Source Database / ID:  PlasmoDB   |   GeneDB   |   MPMP

pI: 4.3779 | Length (AA): 492 | MW (Da): 59628 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF06991   Microfibril-associated/Pre-mRNA processing

Gene Ontology

Mouse over links to read term descriptions.
GO:0005578   proteinaceous extracellular matrix  
GO:0005576   extracellular region  
GO:0005201   extracellular matrix structural constituent  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
59 178 2fxo (A) 841 958 18.00 0.11 0.01 0.436102 -0.76
69 219 4ilo (A) 25 174 11.00 0.46 0.03 0.559111 -1.74
79 171 3kh5 (A) 71 159 35.00 0.26 0.25 0.394124 0.55

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile Oocyst, Ring, Female Gametocyte, Male Gametocyte. Zanghi G Lasonder E
Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile gametocyte, merozoite, sporozoite, early ring, early schizont, early trophozoite, late ring, late trophozoite, Sporozoite. PlasmoDB Zanghi G
Upregulation Percent Ranking Stage Dataset
Mid 40-60% percentile intra-erythrocytic - 8 hs, intra-erythrocytic - 16 hs, intra-erythrocytic - 24 hs, late schizont. Otto TD PlasmoDB
Upregulation Percent Ranking Stage Dataset
Lower 20-40% percentile intra-erythrocytic - 0 hs, intra-erythrocytic - 32 hs, intra-erythrocytic - 40 hs. Otto TD
Upregulation Percent Ranking Stage Dataset
Lower 0-20% percentile intra-erythrocytic - 48 hs. Otto TD
Show/Hide expression data references
  • Zanghi G A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection.
  • PlasmoDB Data on upregulation of P. falciparum genes in different life cycle stages, combined from several microarray experiments available in PlasmoDB
  • Otto TD New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq.
  • Lasonder E Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression.

Orthologs

Ortholog group members (OG5_128838)

Species Accession Gene Product
Arabidopsis thaliana AT5G17900   microfibrillar-associated protein 1
Arabidopsis thaliana AT4G08580   microfibrillar-associated protein-like protein
Babesia bovis BBOV_II002390   micro-fibrillar-associated protein 1 C-terminus containing protein
Candida albicans CaO19.13698   similar to D. melanogaster CG1017 gene product
Candida albicans CaO19.6342   similar to D. melanogaster CG1017 gene product
Caenorhabditis elegans CELE_F43G9.10   Protein MFAP-1
Dictyostelium discoideum DDB_G0282219   microfibrillar-associated protein 1-like protein
Drosophila melanogaster Dmel_CG1017   Microfibril-associated protein 1
Echinococcus granulosus EgrG_000149200   microfibrillar associated protein 1
Entamoeba histolytica EHI_098310   microfibril-associated protein, putative
Echinococcus multilocularis EmuJ_000149200   microfibrillar associated protein 1
Homo sapiens ENSG00000140259   microfibrillar-associated protein 1
Mus musculus ENSMUSG00000068479   microfibrillar-associated protein 1A
Mus musculus 100034361   microfibrillar-associated protein 1B
Neospora caninum NCLIV_051740   hypothetical protein
Oryza sativa 9266601   Os06g0335101
Oryza sativa 4329017   Os02g0280100
Plasmodium berghei PBANKA_1339400   micro-fibrillar-associated protein, putative
Plasmodium falciparum PF3D7_1324200   micro-fibrillar-associated protein, putative
Plasmodium knowlesi PKNH_1204600   micro-fibrillar-associated protein, putative
Plasmodium vivax PVX_116660   Micro-fibrillar-associated protein 1 C-terminus domain containing protein
Plasmodium yoelii PY01638   hypothetical protein
Schistosoma japonicum Sjp_0097670   Microfibrillar-associated protein 1, putative
Schistosoma japonicum Sjp_0069960   ko:K00784 ribonuclease Z [EC3.1.26.11], putative
Schistosoma mansoni Smp_068100   microfibril-associated protein
Schmidtea mediterranea mk4.000357.12   Microfibrillar-associated protein 1
Toxoplasma gondii TGME49_214590   micro-fibrillar-associated protein 1
Theileria parva TP04_0360   hypothetical protein
Trichomonas vaginalis TVAG_151600   microfibril-associated protein, putative

Essentiality

PF3D7_1324200 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_F43G9.10 Caenorhabditis elegans embryonic lethal wormbase
CELE_F43G9.10 Caenorhabditis elegans larval arrest wormbase
CELE_F43G9.10 Caenorhabditis elegans slow growth wormbase
CELE_F43G9.10 Caenorhabditis elegans sterile wormbase
TGME49_214590 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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User comments

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Gene identifier PF3D7_1324200 (Plasmodium falciparum), micro-fibrillar-associated protein, putative
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