Detailed view for PFE0505w

Basic information

TDR Targets ID: 4133
P. falciparum 3D7, cyclophilin, putative
Source Database / ID: PlasmoDB / PFE0505w  GeneDB / PFE0505w

pI: 7.3409 | Length (AA): 747 | MW (Da): 87040 | Number of Paralogs: 0

EC number(s): 5.2.1.8 | Enzyme, KEGG, Brenda (mouse over to display more information)

Signal peptide: N | GPI Anchor: N (Show evidence) | Predicted trans-membrane segments: 0

Pfam domains

PF00400   WD40

Gene Ontology GO:0016018   cyclosporin A binding  

Function: (mouse over links to read term descriptions)

GO:0003755   peptidyl-prolyl cis-trans isomerase activity  
Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Functional classes

GO:0005488 binding
GO:0009987 cellular process
GO:0016853 isomerase activity

Structural information

Modbase 3D models: PFE0505w  

PDB structures: 2FU0  

Expression

Upregulation ranking: this gene ranks in the upper 80-100% group of genes.
Shows this level of upregulation in: early ring.

Upregulation ranking: this gene ranks in the upper 60-80% group of genes.
Shows this level of upregulation in: merozoite, sporozoite, early schizont, early trophozoite, late ring, late schizont, late trophozoite.

Upregulation ranking: this gene ranks in the mid 40-60% group of genes.
Shows this level of upregulation in: gametocyte.

References
PlasmoDB: Data on upregulation of P. falciparum genes in different life cycle stages, combined from several microarray experiments available in PlasmoDB.

Antigenicity

Number of putative antigenic epitopes: 25
Cumulative epitope score: 28.3
Normalized epitope score: 3.8
Percentile: 43.1 (this protein belongs to the top 56.9% proteins in the genome of P. falciparum 3D7, based on the predicted antigenicity).

[+/–]   More information on this prediction ...

Orthologs

OrthoMCL 4 cluster: OG4_11783
Number of Paralogs: 0

Ortholog group members from selected species:
Arabidopsis thaliana NP_190046   CYP71 (CYCLOPHILIN71); chromatin binding / histone binding ... |   OrthoMCL
Babesia bovis XP_001610877.1   peptidyl-prolyl cis-trans isomerase ... |   OrthoMCL
Brugia malayi Bm1_28740   cyclophilin-type peptidyl-prolyl cis-trans isomerase-15, Bmc... |   OrthoMCL
Caenorhabditis elegans Y87G2A.6   CE24686 WBGene00000891 locus:cyn-15 cyclophilin status:Parti... |   OrthoMCL
Cryptosporidium hominis Chro.70067   protein-related ... |   OrthoMCL
Cryptosporidium muris CMU_006350   peptidyl-prolyl cis-trans isomerase, cyclophilin-type famil... |   OrthoMCL
Cryptosporidium neoformas XP_568847   peptidyl-prolyl cis-trans isomerase ... |   OrthoMCL
Cryptosporidium parvum cgd7_520   cyclincyclophilin like peptidyl-prolyl cis-trans isomerase ... |   OrthoMCL
Drosophila melanogaster FBpp0072216   |   OrthoMCL
Escherichia coli K12 NP_415058.1   peptidyl-prolyl cis-trans isomerase B (rotamase B) [Escheric... |   OrthoMCL
Homo sapiens ENSP00000261308   |   OrthoMCL
Mycobacterium leprae strain TN ML0011   Probable peptidyl-prolyl cis-trans isomerase PpiA (PPIase A)... |   OrthoMCL
Mus musculus ENSMUSP00000022226   |   OrthoMCL
Mycobacterium tuberculosis Rv0009   PROBABLE IRON-REGULATED PEPTIDYL-PROLYL CIS-TRANS ISOMERASE ... |   OrthoMCL
Neospora caninum NCLIV_009630   |   OrthoMCL
Oryza sativa NP_001062485   Os08g0557500 ... |   OrthoMCL
Plasmodium berghei PB000833.02.0   cyclophilin, putative ... |   OrthoMCL
Plasmodium chabaudi PCAS_110950   cyclophilin, putative ... |   OrthoMCL
P. falciparum 3D7 PFE0505w (this record).   cyclophilin, putative... |   OrthoMCL
Plasmodium knowlesi PKH_102270   cyclophilin, putative ... |   OrthoMCL
Plasmodium vivax PVX_098070   cyclophilin, putative... |   OrthoMCL
Plasmodium yoelii PY03899   putative protein-related ... |   OrthoMCL
Schistosoma mansoni Smp_133820   peptidyl-prolyl cis-trans isomerase-like... |   OrthoMCL
Toxoplasma gondii TGME49_120640   cyclophilin, putative... |   OrthoMCL

Essentiality PFE0505w has essentiality data
Gene/Ortholog: mtu9 (OG4_11783); Phenotype: non-essential; Source study: nmpdr
Gene/Ortholog: eco514 (OG4_11783); Phenotype: undefined; Source study: blattner
Gene/Ortholog: eco514 (OG4_11783); Phenotype: essential; Source study: gerdes
Gene/Ortholog: eco514 (OG4_11783); Phenotype: non-essential; Source study: keio
Gene/Ortholog: eco514 (OG4_11783); Phenotype: non-essential; Source study: shigen

[+/–]   Show essentiality data references.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

Associated compounds / Druggability

  • Curated from literature

    No chemical compounds is associated to this gene

  • Predicted associations

    • By orthology to known druggable targets

      • No orthologous druggable targets

    • By sequence similarity to non orthologous druggable targets

      • No additional associated druggable targets
    • Assayability

    Assay information

    Assay: Assay for FK-Binding Protein Peptidyl-Prolyl Isomerase Activity (5.2.1.8 ); Source: Sigma-Aldrich
    Description: Automatic link to known assays based on EC numbers.

    Assay: Assayed; Source: BRENDA
    Description: An enzyme with this EC number or name or sequence has been assayed in Plasmodium falciparum ( 1 );

    Reagent availability

    Reagent: PFE0505w; Type: cloned gene; Source: BRENDA
    Notes: A gene with this EC number or name or sequence has been cloned from Plasmodium falciparum ( 1 2 3 );

    Reagent: PFE0505w; Type: purified protein; Source: BRENDA
    Notes: A protein with this EC number or name or sequence has been purified from Plasmodium falciparum ( 1 2 );

    Bibliographic references

    13 literature references were collected for this gene.

    If you have references for this gene, please enter them in a user comment (below) or contact us.

    User comments

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