Detailed view for PF3D7_0520900

Basic information

TDR Targets ID: 4241
Plasmodium falciparum, adenosylhomocysteinase
Source Database / ID:  PlasmoDB   |   GeneDB   |   MPMP

pI: 5.7114 | Length (AA): 479 | MW (Da): 53839 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG3

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00670   S-adenosyl-L-homocysteine hydrolase, NAD binding domain
PF05221   S-adenosyl-L-homocysteine hydrolase

Gene Ontology

Mouse over links to read term descriptions.
GO:0019510   S-adenosylhomocysteine catabolic process  
GO:0005488   binding  
GO:0004013   adenosylhomocysteinase activity  
GO:0003824   catalytic activity  
GO:0051287   NAD binding  
GO:0008152   metabolic process  
GO:0006730   one-carbon compound metabolic process  

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
3 479 1li4 (A) 4 432 55.00 0 1 1.37 -0.92
4 479 1v8b (A) 4 479 99.99 0 1 2.24 -1.86
4 479 1v8b (A) 4 479 99.99 0 1 2.22604 -1.4

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

PDB tag
  • 1V8B:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile intra-erythrocytic - 0 hs, intra-erythrocytic - 8 hs, intra-erythrocytic - 16 hs, intra-erythrocytic - 24 hs, intra-erythrocytic - 32 hs, intra-erythrocytic - 40 hs, intra-erythrocytic - 48 hs, merozoite, sporozoite, early ring, early schizont, early trophozoite, late ring, late schizont, late trophozoite, Oocyst, Ring. Otto TD PlasmoDB Zanghi G
Upregulation Percent Ranking Stage Dataset
Mid 40-60% percentile gametocyte, Sporozoite, Female Gametocyte, Male Gametocyte. PlasmoDB Zanghi G Lasonder E
Show/Hide expression data references
  • Zanghi G A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection.
  • PlasmoDB Data on upregulation of P. falciparum genes in different life cycle stages, combined from several microarray experiments available in PlasmoDB
  • Lasonder E Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression.
  • Otto TD New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq.

Orthologs

Ortholog group members (OG5_127233)

Species Accession Gene Product
Arabidopsis thaliana AT4G13940   adenosylhomocysteinase 1
Arabidopsis thaliana AT3G23810   adenosylhomocysteinase 2
Babesia bovis BBOV_I001740   adenosylhomocysteinase (S-adenosyl-L-homocysteinehydrolase)
Brugia malayi Bm1_48165   Adenosylhomocysteinase
Candida albicans CaO19.11392   Putative S-adenosyl-L-homocysteine hydrolase
Candida albicans CaO19.3911   Putative S-adenosyl-L-homocysteine hydrolase
Caenorhabditis elegans CELE_K02F2.2   Protein AHCY-1
Cryptosporidium hominis Chro.30017   adenosylhomocysteinase
Cryptosporidium parvum cgd3_80   S-adenosylhomocysteinase
Dictyostelium discoideum DDB_G0278037   hypothetical protein
Dictyostelium discoideum DDB_G0278035   hypothetical protein
Dictyostelium discoideum DDB_G0267418   AdoHyc hydrolase
Drosophila melanogaster Dmel_CG11654   Adenosylhomocysteinase at 13
Echinococcus granulosus EgrG_000076900   adenosylhomocysteinase
Entamoeba histolytica EHI_068250   adenosylhomocysteinase, putative
Echinococcus multilocularis EmuJ_000076900   adenosylhomocysteinase
Homo sapiens ENSG00000101444   adenosylhomocysteinase
Leishmania braziliensis LbrM.35.4150   S-adenosylhomocysteine hydrolase
Leishmania braziliensis LbrM.35.4140   S-adenosylhomocysteine hydrolase
Leishmania donovani LdBPK_364100.1   S-adenosylhomocysteine hydrolase
Leishmania infantum LinJ.36.4100   S-adenosylhomocysteine hydrolase
Leishmania major LmjF.36.3910   S-adenosylhomocysteine hydrolase
Leishmania mexicana LmxM.36.3910   S-adenosylhomocysteine hydrolase
Loa Loa (eye worm) LOAG_04848   adenosylhomocysteinase
Mycobacterium leprae ML0771   putative S-adenosyl-L-homocysteine hydrolase SahH
Mus musculus ENSMUSG00000027597   S-adenosylhomocysteine hydrolase
Mus musculus 102643284   adenosylhomocysteinase-like
Mycobacterium tuberculosis Rv3248c   Probable adenosylhomocysteinase SahH (S-adenosyl-L-homocysteine hydrolase) (adohcyase)
Mycobacterium ulcerans MUL_2592   S-adenosyl-L-homocysteine hydrolase
Neospora caninum NCLIV_047660   hypothetical protein
Oryza sativa 4350455   Os11g0455500
Plasmodium berghei PBANKA_1235600   adenosylhomocysteinase, putative
Plasmodium falciparum PF3D7_0520900   adenosylhomocysteinase
Plasmodium knowlesi PKNH_1012000   adenosylhomocysteinase, putative
Plasmodium vivax PVX_080200   adenosylhomocysteinase(S-adenosyl-L-homocystein e hydrolase), putative
Plasmodium yoelii PY02893   adenosylhomocysteinase
Saccharomyces cerevisiae YER043C   adenosylhomocysteinase
Schistosoma japonicum Sjp_0009180   ko:K01251 adenosylhomocysteinase [EC3.3.1.1], putative
Schistosoma mansoni Smp_028440.1   adenosylhomocysteinase
Schmidtea mediterranea mk4.041384.00   Adenosylhomocysteinase
Schmidtea mediterranea mk4.002401.00   Adenosylhomocysteinase
Schmidtea mediterranea mk4.007090.00   Adenosylhomocysteinase
Schmidtea mediterranea mk4.038032.00   Adenosylhomocysteinase
Trypanosoma brucei gambiense Tbg972.11.10770   S-adenosylhomocysteine hydrolase, putative
Trypanosoma brucei Tb927.11.9590   S-adenosylhomocysteine hydrolase, putative
Trypanosoma congolense TcIL3000.11.10090   S-adenosylhomocysteine hydrolase, putative
Trypanosoma congolense TcIL3000_0_20500   S-adenosylhomocysteine hydrolase, putative
Trypanosoma cruzi TcCLB.511589.200   S-adenosylhomocysteine hydrolase, putative
Trypanosoma cruzi TcCLB.511229.50   S-adenosylhomocysteine hydrolase, putative
Toxoplasma gondii TGME49_225050   adenosylhomocysteinase, putative
Toxoplasma gondii TGME49_326800   S-Adenosyl homocysteine hydrolase
Theileria parva TP03_0160   S-adenosyl-L-homocysteine hydrolase, putative
Trichomonas vaginalis TVAG_210320   adenosylhomocysteinase, putative
Trichomonas vaginalis TVAG_405240   adenosylhomocysteinase, putative

Essentiality

PF3D7_0520900 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
mtu3307 Mycobacterium tuberculosis essential nmpdr
Tb11.01.1350 Trypanosoma brucei significant gain of fitness in bloodstream forms (3 days) alsford
Tb11.01.1350 Trypanosoma brucei significant gain of fitness in bloodstream forms (6 days) alsford
Tb11.01.1350 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb11.01.1350 Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_K02F2.2 Caenorhabditis elegans embryonic lethal wormbase
CELE_K02F2.2 Caenorhabditis elegans larval arrest wormbase
CELE_K02F2.2 Caenorhabditis elegans larval lethal wormbase
YER043C Saccharomyces cerevisiae inviable yeastgenome
PBANKA_1235600 Plasmodium berghei Slow plasmo
TGME49_225050 Toxoplasma gondii Essentiality uncertain sidik
TGME49_326800 Toxoplasma gondii Essentiality uncertain sidik
Show/Hide essentiality data references
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan

Phenotypes and Validation (curated)

Annotated phenotypes:

Affected Entity Phenotypic quality Occurs in Occurs at Evidence Observed in Drugs/Inhibitors
growth (GO:0040007) lethal (sensu genetics) (PATO:0000718) multi-cellular organism (CARO:0000012) bloodstream stage (PLO:0040) in vivo inhibition (TDR:00016) Plasmodium berghei No drug identifiers listed for this gene.
Annotator: saralph@unimelb.edu.au. Comment: Drug: 2-fluoronoraristeromycin. . References: 15476817 16005528
growth (GO:0040007) lethal (sensu genetics) (PATO:0000718) multi-cellular organism (CARO:0000012) bloodstream stage (PLO:0040) in vivo inhibition (TDR:00016) Plasmodium falciparum No drug identifiers listed for this gene.
Annotator: saralph@unimelb.edu.au. Comment: Drug: nucleoside analogues. . References: 11134963 12903145 12910461 14592485 15476817 16005528 16682206 2200410

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Druggability index (range: 0 to 1): 0.8

Known modulators for this target

Compound Source Reference
ChEMBL23 References
ChEMBL23 References
ChEMBL23 References
ChEMBL23 References
ChEMBL23 References

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens adenosylhomocysteinase Compounds References
Trypanosoma cruzi S-adenosylhomocysteine hydrolase, putative Compounds References
Rattus norvegicus Adenosylhomocysteinase Compounds References
Trypanosoma cruzi S-adenosylhomocysteine hydrolase, putative Compounds References
Mus musculus S-adenosylhomocysteine hydrolase Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0141 0.3127 0.3127
0.025 1 1
0.1097 0.4016 1
0.066 0.3639 0.5457
0.0536 0.645 1
0.1182 0.8803 1
0.0655 0.3679 0.517
0.0394 0.2731 1
0.058 1 1
0.0156 0.2959 1
0.1053 0.5182 1
0.1496 1 1
0.0252 0.3108 1
0.0934 1 1
0.1462 1 1
0.0566 0.6193 1
0.0405 1 0.5
0.0263 1 1
0.1116 1 1
0.0853 0.2879 0.6065
0.0294 1 0.5
0.0311 0.2656 1
0.0643 0.2784 0.9453
0.0497 1 1
0.0673 0.3582 0.5271
0.0504 1 1
0.1186 0.9271 1
0.1833 0.9513 1
0.0656 0.381 0.5715
0.1687 0.892 1
0.1426 0.5451 1
0.1021 1 1
0.1488 1 1
0.0809 1 0.5
0.0118471 1 0.5
0.0887 1 1
0.1488 1 1
0.0139 0.3635 0.2359
0.2377 0.2546 1
0.0378 0.3603 1
0.0113675 0.72633 0.5
0.0514 0.3954 1
0.0115149 1 0.5
0.0638 0.3507 0.5571
0.0903 1 1
0.1086 1 1
0.0286 0.416 0.5
0.0853 0.2876 0.6019
0.6378 0.2815 1
0.132 0.4485 1
0.1789 1 1
0.0312 0.3929 1
0.1955 1 1
0.0777 1 1
0.0669 0.4832 0.9604
0.1286 0.9122 1
0.0133 0.9021 0.5
0.0664 0.36 0.5396
0.025 1 1
0.0128 1 0.5
0.0408 0.4932 1
0.0258 0.3126 1
0.1509 1 1
0.0523 0.5948 1
0.0156 0.2623 1
0.0156 1 0.5
0.0156 1 0.5
0.1712 1 1
0.0312 1 1
0.0609 0.5517 1
0.0604 0.7675 1
0.1021 1 1
0.0664 0.483 0.9601
0.1192 1 1
0.0256 0.2506 0.5185
0.0733 0.9698 0.5
0.1183 0.4517 1
0.0133 1 0.5
0.1102 0.4011 1
0.055 0.3005 1
0.0643 0.2784 0.9453
0.1089 0.402 1
0.1191 0.7242 1
0.0384 1 0.5
0.0412 0.5117 1
0.0536 0.3093 1
0.9772 0.5193 1
0.0156 0.6436 1
0.0138 1 0.5
0.1193 0.8899 1
0.0527 0.3079 0.5
0.0887 1 1
0.0126 1 0.5
0.0647 0.391 1
0.1202 0.9019 1
0.014 0.2705 0.7813
0.13 0.7908 1
0.0922 1 1
0.0131 1 0.5
0.1161 1 1
0.1579 1 1
0.1635 0.3597 1
0.1328 0.6257 1
0.0435 1 0.5
0.0718 1 0.5
0.2244 1 0.5
0.9772 0.5193 1
0.082 0.4366 1
0.1344 1 1
0.0703 0.7014 0.5
0.0406 0.8588 0.5
0.2377 0.2546 1
0.0563 0.5962 1
0.0816 1 1
0.0826 0.4366 1
0.1086 1 1
0.1029 1 1
0.2092 1 1
0.1097 0.3093 1
0.025 1 0.5
0.0506 0.2753 1
0.1358 1 1
0.1651 0.2784 1
0.1489 0.2652 1
0.1333 0.3602 1
0.0922 1 1
0.1178 0.2644 1
0.0513 1 0.5
0.1125 1 0.5
0.0692 0.3778 0.5557
0.1789 1 1
0.0125 0.4045 1
0.0655 0.3604 0.5535
0.1007 1 1
0.0144 0.2887 0.5
0.5444 0.2514 1
0.1053 0.5182 1
0.1861 1 1
0.0563 0.6166 1
0.0156 0.5921 1
0.0766 0.3012 0.4573
0.9772 0.5193 1
0.0816 1 1
0.1125 1 0.5
0.1184 0.8952 1
0.1306 0.9118 1
0.0312 1 0.5
0.0692 0.4818 0.6214
0.0132 1 1
0.0843 0.4899 0.7351
0.0802 0.5785 0.5
0.2156 1 1
0.0558 0.6202 1
0.0408 0.4932 1
0.1178 0.2644 1
0.095 1 1
0.174 0.36 1
0.0126 1 0.5
0.1976 1 1
0.177 1 0.5
0.154 0.8454 1
0.053 0.4065 1
0.132 0.4485 1
0.1635 0.3613 1
0.025 1 0.5
0.1543 0.6284 1
0.0777 1 1
0.1397 0.8197 1
0.066 0.3792 0.5669
0.1712 1 1
0.0931 1 1
0.0259 0.3568 1
0.0268 0.318 1
0.0535 1 0.5
0.0728544 0.267421 1
0.1675 0.6527 1
0.1624 1 0.5
0.0646 1 1
0.0156 1 0.5
0.1651 0.2784 1
0.0519 0.3154 1
0.1054 0.7848 1
0.0919 1 0.5
0.0789 0.6006 1
0.0791 1 0.5
0.1089 0.4016 1
0.1732 1 1
0.014 0.2705 0.7813
0.2206 0.4384 1
0.027 1 1
0.1836 1 1
0.2912 0.8033 1
0.025 0.2768 1
0.174 0.36 1
0.041 0.5227 0.5
0.0408 0.9573 0.5
0.1603 1 0.5
0.0156 0.3073 1
0.1178 0.2644 1
0.0787 0.5705 1
0.076 0.5037 1
0.0934 1 1
0.132 0.4485 1
0.0822 0.4374 1
0.0125 0.3135 0.2258
0.1678 0.4587 1
0.3068 0.8465 1
0.0534 0.3605 1
0.0138 1 0.5
0.0271 0.3201 1
0.025 0.332 1
0.0125 0.4045 1
0.0156 0.2822 1
0.0156 1 1
0.2377 0.2546 1
0.2312 1 1
0.1021 1 1
0.1021 1 1
0.0394 1 1
0.0156 0.405 1
0.1921 1 1
0.0766 0.3012 0.4573
0.0641 0.3715 0.5628
0.0763 1 1
0.0766 0.3012 0.4573
0.1273 1 0.5
0.1333 0.3569 1
0.013 1 0.5
0.132 1 1
0.0156 1 0.5
0.0552 0.3018 1
0.0156 1 0.5
0.0267 0.3212 1
0.0394 0.2731 1
0.0394 0.2731 1
0.0516 1 1
0.0327147 0.452889 1
0.1153 0.601 1
0.1178 0.2644 1
0.0387 1 1
0.1054 0.8828 1
0.136 1 1
0.1178 0.2644 1
0.0408 0.564 1
0.0131 1 1
0.1927 1 1
0.1091 0.4009 1
0.0816 1 1
0.1272 0.3696 1
0.0646 1 1
0.1568 1 1
0.159 0.9097 1
0.0156 0.2822 1
0.1831 0.8477 1
0.105 1 1
0.0536 0.3093 1
0.1466 1 1
0.0643 0.2784 0.9453
0.2219 1 0.5
0.9772 0.5193 1
0.0791 0.5746 1
0.0529 0.2896 1
0.1097 0.6221 1
0.0919 0.6968 1
0.2086 0.6289 1
0.0774 1 1
0.117 1 1
0.0156 0.6436 1
0.0312 0.3929 1
0.1212 0.5667 1
0.1333 0.3602 1
0.0529 0.2896 1
0.0826 0.4366 1
0.0893 1 1
1.0824 0.5083 1
0.0143 1 0.5
0.0584 0.4093 1
0.0797 1 1
0.0643 0.4391 0.5457
0.1691 1 1
0.3015 1 1
0.0424 0.2534 1
0.025 0.258 1
0.1691 1 1
0.0523 0.5948 1
0.0412 0.7642 1
0.1178 0.2644 1
0.0156 0.2959 1
0.0057 0.4886 1
0.0419 0.4097 0.5
0.066 0.3792 0.5669
0.026 0.2883 0.5
0.0516 0.5919 1
0.191 0.3927 1
1.03 0.5161 1
0.0961 0.5024 1
0.1177 0.6497 1
0.0156 1 0.5
0.1468 1 1
0.0057 0.4656 1
0.1573 0.8124 1
0.0524 0.4012 1
0.1636 1 1
0.0567 0.6596 1
0.0507 0.6054 1
0.0376 0.3521 1
0.0706 0.4643 0.6957
0.0631 0.2501 1
0.2153 1 1
0.0275 0.3215 1
0.0568 0.5331 1
0.1054 0.8828 1
0.0156 1 0.5
0.0643 0.6043 0.6043
0.0312 1 1
0.1691 1 1
0.1669 0.8388 1
0.025 0.2959 1
0.0293 1 1
0.0566 0.6193 1
0.0607 1 0.5
0.1789 1 1
0.0282 0.7275 0.5
0.1651 0.2784 1
0.0922 1 1
0.0385 0.4358 1
0.0156 0.3479 0.5
0.0942 1 1
0.6378 0.2815 1
0.1836 1 1
0.1547 0.7724 1
0.289 1 1
0.1158 1 1
0.1272 0.3696 1
0.014 0.2705 0.7813
0.0156 1 0.5
0.1216 1 1
0.056 0.6202 1
0.0578 0.592 1
0.132 0.4485 1
0.1819 1 1
0.0507 1 1
0.0647 0.3574 0.5977
0.0252 0.2676 1
0.1702 1 1
0.0546 0.6677 0.5
0.0779 1 1
0.0141 0.7436 0.7436
0.0393 1 0.5
0.0294 1 0.5
0.1178 0.2644 1
0.014 0.2705 0.7813
0.1212 0.5667 1
0.0643 0.3242 0.4888
0.1097 0.3093 1
0.0252 1 1
0.0381 0.256 0.3291
0.1959 1 1
0.0511 0.6306 1
0.0609 0.5517 1
0.0513 0.3143 1
0.1212 0.5667 1
0.0771 0.4163 1
0.0135 0.4524 0.5
0.1339 1 1
0.0312 1 0.5
0.1442 0.3826 1
0.0823 1 1
0.0251 0.2939 1
0.0253 0.5481 0.5
0.0126 0.2939 0.2939
0.0379 1 0.5
0.0134 0.2998 0.0868
0.0156 0.2959 1
0.0402 1 0.5
0.0376 0.4598 1
0.1272 0.3696 1
0.0141 0.7416 0.7416
0.1172 1 1
0.0529 0.2896 1
0.1219 1 1
0.027 0.3122 0.8045
0.0516 0.285 1
0.0394 1 1
0.1178 0.2644 1
0.0433 1 0.5
0.0135 0.5246 0.7683
0.1635 0.3582 1
0.0266 0.3961 1
0.0126 0.3372 1
0.1178 0.2644 1
0.5754 0.2537 1
0.177 1 0.5
0.1921 1 1
0.0511 0.6306 1
0.0636 0.9178 1
0.0816 1 1
0.1439 1 1
0.1053 0.5182 1
0.1202 0.9019 1
0.0956 1 1
0.0383 0.3801 1
0.0913 0.6921 1
0.0509 0.5203 1
0.0128 1 0.5
0.0133 0.3063 1
0.0312 1 0.5
0.1178 0.2644 1
0.1183 0.4517 1
0.1183 1 1
0.095 1 1
0.1175 0.6548 1
0.0293 1 1
0.0559 0.2625 1
0.0895 0.5925 1
0.1212 0.5667 1
0.0252 0.5261 1
0.0057 0.4656 1
0.0812 1 1
0.1304 1 1
0.0382 0.2577 0.3273
0.1125 1 0.5
0.1323 1 1
0.0156 0.3129 1
0.027 0.3213 1
0.1651 0.2784 1
0.0816 1 1
0.153 1 1
0.0133 0.9021 0.5
0.2156 1 1
0.0156 1 0.5
0.0126 0.4822 1
0.0394 0.2731 1
0.0664 0.36 0.5396
0.2174 1 1
0.1528 1 0.5
0.0439 0.4506 1
0.1659 0.8239 1
0.0125 0.3244 0.154
0.1954 0.4624 1
0.0511 0.6201 1
0.0893 0.8407 1
0.079 1 1
0.132 0.4485 1
0.0448 0.2972 1
0.1651 0.2784 1
0.1464 0.9042 1
0.0156 1 0.5
0.0534 1 0.5
0.1056 0.7929 1
0.9772 0.5193 1
0.0254 0.9361 1
0.0643 0.3749 0.4879
0.1442 0.9023 1
0.0669 0.4838 0.6141
0.0568 1 0.5
0.0809 1 0.5
0.0259 0.5223 0.5
0.5444 0.2514 1
0.1178 0.2644 1
1.03 0.5161 1
0.2859 0.4853 1
0.0271 0.3192 1
0.0536 0.3093 1
0.0156 0.8333 0.5
0.0258 0.2894 1
0.0728544 0.267421 1
0.0312 1 1
0.0156 0.2959 1
0.1079 0.2538 1
0.2203 1 1
0.1464 0.898 1
0.0546 0.6677 0.5
0.0387 1 1
0.0656 0.4815 0.9597
0.066 0.378 0.5622
0.0125 1 0.5
0.0265 0.3233 1
0.0664 0.3634 0.5356
0.0408 0.4932 1
0.1294 1 1
0.1178 0.2644 1
0.0426 0.2739 1
0.1178 0.2644 1
0.0282 1 1
0.0125 0.3738 0.3695
0.0129 0.6264 0.6264
0.0142 1 1
0.1178 0.2644 1
0.1029 1 1
0.053 0.4065 1
0.1505 1 1
0.0152 0.483 0.8343
0.0552 0.302 1
0.0156 1 0.5
0.132 0.4485 1
0.1089 0.4016 1
0.0802 0.5785 0.5
0.1058 0.6432 1
0.1468 1 1
0.1635 0.3564 1
0.2552 1 1
0.0156 0.5921 1
0.1021 1 1
0.0766 0.3012 0.4573
0.0511 0.6306 1
0.0401 0.3777 1
0.132 0.4485 1
0.0125 0.3244 0.154
0.1921 1 1
0.0735 1 0.5
0.0895 1 1
0.0559 0.3885 0.4968
0.0534 0.3605 1
0.1691 1 1
0.2174 1 1
0.0448 0.2972 1
0.1079 0.2538 1
0.0156 1 0.5
0.0916 0.5561 1
0.1166 0.7038 1
0.1183 0.4517 1
0.0125 0.3699 1
0.0558 1 0.5
0.1357 0.4966 1
0.051 0.2609 0.4242
0.0669 0.384 0.5737
0.0679 0.4832 0.9616
0.066 0.3582 0.5272
0.0392 1 0.5
0.0546 0.6203 1
0.0156 0.9326 1
0.2206 0.4384 1
0.0694 1 1
0.1357 0.4966 1
0.0156 0.8333 0.5
0.1095 1 1
0.0113675 0.72633 0.5
0.0881 1 1
0.1201 1 1
0.0669 0.8298 1
0.0312 1 0.5
0.1037 0.6155 1
0.057 0.6601 1
0.1328 0.6257 1
0.1428 0.2976 1
0.0253 0.5698 0.8157
0.0424 0.2534 1
0.0728544 0.267421 1
0.1333 0.3569 1
0.0156 0.3055 1
0.1053 0.588 1
0.0816 0.4374 1
0.1212 0.5667 1
0.0934 1 1
0.0125 0.4045 1
0.0156 0.405 1
0.066 0.3687 0.5343
0.1659 0.8329 1
0.1428 0.2976 1
0.3023 1 1
0.1678 0.4587 1
0.0413 1 0.5
0.0256 0.2959 1
0.1651 0.2784 1
0.0341 1 0.5
0.026 0.3124 1
0.0565 0.3001 1
0.1102 0.4014 1
0.0575 0.5919 1
0.076 1 1
0.1053 0.5182 1
0.1053 0.2531 1
0.0558 0.6202 1
0.0264 1 1
0.0939 1 0.5
0.0559 0.3913 0.5039
0.1489 0.2652 1
0.1994 1 1
0.0664 0.3774 0.5494
0.1021 1 1
0.0527 1 1
0.0135 0.5246 0.7683
0.1921 1 1
0.066 0.3792 0.5669
0.0971 1 1
0.1468 1 1
0.0775 1 1
0.0645 0.9523 1
0.1859 1 1
0.0422 1 0.5
0.2205 1 0.5
0.6674 0.292 1
0.1053 0.2531 1
0.0382 0.2584 0.3323
0.0853 0.2876 0.6019
0.2899 0.4376 1
0.1591 0.8219 1
0.1094 0.4015 1
0.0519 0.3154 1
0.013 0.3484 0.3719
0.1082 0.4019 1
0.0156 1 0.5
0.0809 1 0.5
0.0282 0.7275 0.5
0.132 0.4485 1
0.0787 1 1
0.105 1 1
0.1126 1 0.5
0.0581 0.5913 1
0.1554 0.7216 1
0.2377 0.2546 1
0.1855 1 1
0.0527 0.5978 1
0.0677 0.3582 0.5271
0.0391 1 0.5
0.0376 0.278 1
0.093 1 0.5
0.1045 0.6608 1
0.0631 0.2501 1
0.1191 0.7242 1
0.1178 0.2644 1
0.1021 1 1
0.0647 0.3855 1
0.2206 0.4384 1
0.0293 0.4105 1
0.132 0.4485 1
0.1917 0.5798 1
0.1193 0.8899 1
0.0156 0.3823 0.5
0.0536 0.5941 1
0.066 0.3381 0.5423
0.0762 0.3634 1
0.0765 1 1
0.1107 0.4026 1
0.132 0.4485 1
0.0643 0.2784 0.9453
0.0536 0.3093 1
0.0584 0.4093 1
0.0156 1 1
0.1194 0.9096 1
0.0853 0.2879 0.6065
0.0647 0.3855 1
0.0507 0.6205 1
0.2174 1 1
0.0591 1 1
0.1488 1 1
0.0325 0.3771 1
0.0408 0.564 1
0.0476 1 0.5
0.0790453 0.57069 1
0.1104 0.4019 1
0.0549 0.6203 1
0.0156 1 0.5
0.2377 0.2546 1
0.1184 0.8952 1
0.0156 1 1
0.0977 1 1
0.0933082 1 1
0.0127 1 1
0.1194 0.9096 1
0.0132 0.2995 1
0.0531 0.6205 1
0.0265 0.2881 0.5
0.0609 0.5517 1
0.1212 0.5667 1
0.0647 1 0.5
0.1157 1 1
0.0566 0.6852 1
0.0733 0.9698 0.5
0.0643 0.3686 0.5499
0.0251 0.5179 0.5
0.0534 0.647 1
0.1451 0.8858 1
0.1183 0.4517 1
0.0254 0.2755 1
0.1754 0.3609 1
0.0604 0.7675 1
0.0536 0.3093 1
0.0156 1 0.5
0.1442 0.9023 1
0.066 0.3687 0.5408
0.0382 0.3993 1
0.1395 1 1
0.0921 0.5156 1
0.0254 1 1
0.1198 0.8867 1
0.0281 1 1
0.0296 0.6071 1
0.0907 1 1
0.0382 1 0.5
0.0921 0.5156 1
0.0419 0.2709 0.5
0.0548 0.3944 0.4998
0.0692 0.4817 0.6049
0.0785 0.9561 1
0.0669 0.8298 1
0.0956 0.3447 1
0.1305 1 1
0.0643 0.2784 0.9453
0.1042 1 1
0.1328 0.6257 1
0.1344 1 1
0.0384 1 0.5
0.0118471 1 0.5
0.2082 0.9591 1
0.0271 0.3211 1
0.0643 0.2784 0.9453
0.2174 1 1
0.1444 1 1
0.0956 1 1
0.0952 0.3473 1
0.1698 0.7915 1
0.0534 0.3605 1
0.0156 1 0.5
0.039 0.4188 1
0.0897 0.9277 1
0.2086 0.6289 1
0.0137 0.3979 0.9667
0.119863 1 0.5
0.2206 0.4384 1
0.0252 0.2955 1
0.0452 0.3049 1
0.1464 0.9042 1
0.013 1 0.5
0.132 0.4485 1

Assayability

Assay information

  • Assay for S-Adenosyl-L-Homocysteine Hydrolase (3.3.1.1 ) Sigma-Aldrich
  • Automatic link to known assays based on EC numbers.
  • Inhibitory activity of the compound against P. falciparum S-adenosyl-L-homocysteine hydrolase ChEMBL
  • Inhibitory activity against Plasmodium falciparum S-adenosyl-L-homocysteine hydrolase
  • Inhibitory activity of the compound against P. falciparum S-adenosyl-L-homocysteine hydrolase ChEMBL
  • Inhibitory activity against Plasmodium falciparum S-adenosyl-L-homocysteine hydrolase
  • Inhibition of Plasmodium falciparum SAHH ChEMBL
  • Inhibition of Plasmodium falciparum SAHH
  • Inhibition of Plasmodium falciparum SAHH at 500 uM ChEMBL
  • Inhibition of Plasmodium falciparum SAHH at 500 uM
  • BRENDA Assay
  • An enzyme with this EC number or name or sequence has been assayed in Plasmodium falciparum ( 1 )

Reagent availability

  • Pfal008498AAA;
  • Type Source Notes
    soluble recombinant protein Structural Genomics for Pathogenic Protozoa (SGPP) Pfal008498; Recombinant protein: full-length; Source: P falciparum; adenosylhomocysteinase(S-adenosyl-L-homocysteine hydrolase) ;
  • Reagent:
  • Target Type Source Notes
    PF3D7_0520900 purified protein BRENDA A protein with this EC number or name or sequence has been purified from Plasmodium falciparum ( 1 )

Bibliographic References

19 literature references were collected for this gene.

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Gene identifier PF3D7_0520900 (Plasmodium falciparum), adenosylhomocysteinase
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