Detailed view for LbrM.05.0720

Basic information

TDR Targets ID: 427535
Leishmania braziliensis, hypothetical protein, conserved
Source Database / ID: 

pI: 9.6478 | Length (AA): 367 | MW (Da): 39754 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF04652   Vta1 like

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

Endocytosis (KEGG)

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
7 164 4txr (A) 7 162 29.00 0 1 0.882994 -1.28
24 158 4txp (C) 22 156 34.00 0.0000000084 0.98 0.760752 -0.39
325 364 2rkl (A) 290 329 40.00 0.0000013 0.71 0.62759 -0.64

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_129256)

Species Accession Gene Product
Arabidopsis thaliana AT4G26750   LYST INTERACTING PROTEIN 5
Brugia malayi Bm1_35735   RhoGAP domain containing protein
Caenorhabditis elegans CELE_T23G11.7   Protein T23G11.7, isoform A
Dictyostelium discoideum DDB_G0271488   hypothetical protein
Drosophila melanogaster Dmel_CG7967   CG7967 gene product from transcript CG7967-RA
Echinococcus granulosus EgrG_000675600   protein of unknown function DUF605
Echinococcus multilocularis EmuJ_000675600   protein of unknown function DUF605
Homo sapiens ENSG00000009844   vesicle (multivesicular body) trafficking 1
Leishmania braziliensis LbrM.05.0720   hypothetical protein, conserved
Leishmania donovani LdBPK_050740.1   Vta1 like, putative
Leishmania infantum LinJ.05.0740   hypothetical protein, conserved
Leishmania major LmjF.05.0740   hypothetical protein, conserved
Leishmania mexicana LmxM.05.0740   hypothetical protein, conserved
Loa Loa (eye worm) LOAG_00344   hypothetical protein
Loa Loa (eye worm) LOAG_00343   hypothetical protein
Mus musculus ENSMUSG00000019868   Vps20-associated 1 homolog (S. cerevisiae)
Oryza sativa 4340850   Os06g0308800
Onchocerca volvulus OVOC638  
Plasmodium berghei PBANKA_0210100   vacuolar protein sorting-associated protein VTA1, putative
Plasmodium falciparum PF3D7_0103000   vacuolar protein sorting-associated protein VTA1, putative
Plasmodium knowlesi PKNH_0210600   vacuolar protein sorting-associated protein VTA1, putative
Plasmodium vivax PVX_081605   vacuolar protein sorting-associated protein VTA1, putative
Plasmodium yoelii PY01512   hypothetical protein
Schistosoma japonicum Sjp_0067670   Vacuolar protein sorting-associated protein VTA1 homolog, putative
Schistosoma mansoni Smp_094820   hypothetical protein
Schmidtea mediterranea mk4.000987.05   Vacuolar protein sorting-associated protein VTA1 homolog
Trypanosoma brucei gambiense Tbg972.7.8400   hypothetical protein, conserved
Trypanosoma brucei Tb927.7.7140   Vta1 like, putative
Trypanosoma congolense TcIL3000_0_52490   Vta1 like, putative
Trypanosoma cruzi TcCLB.504175.20   Vta1 like, putative
Trypanosoma cruzi TcCLB.508385.60   Vta1 like, putative

Essentiality

LbrM.05.0720 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.7.7140 Trypanosoma brucei significant gain of fitness in bloodstream forms (3 days) alsford
Tb927.7.7140 Trypanosoma brucei significant gain of fitness in bloodstream forms (6 days) alsford
Tb927.7.7140 Trypanosoma brucei significant gain of fitness in procyclic forms alsford
Tb927.7.7140 Trypanosoma brucei significant gain of fitness in differentiation of procyclic to bloodstream forms alsford
PBANKA_0210100 Plasmodium berghei Dispensable plasmo
Show/Hide essentiality data references
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

No user comments are available for this gene. Log in to add comments, or register.

Enter your comment

User ()
Gene identifier LbrM.05.0720 (Leishmania braziliensis), hypothetical protein, conserved
Title for this comment
Comment