pI: 10.0307 |
Length (AA): 714 |
MW (Da): 81577 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
PDB Structures:
Ortholog group members (OG5_142825)
Species | Accession | Gene Product |
---|---|---|
Leishmania braziliensis | LbrM.31.0620 | calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative |
Leishmania donovani | LdBPK_310480.1 | calpain-like cysteine peptidase, putative |
Leishmania infantum | LinJ.31.0480 | calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative |
Leishmania major | LmjF.31.0460 | calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative |
Leishmania mexicana | LmxM.30.0460f | |
Leishmania mexicana | LmxM.30.0460d | |
Leishmania mexicana | LmxM.30.0460e | |
Leishmania mexicana | LmxM.30.0460a | |
Leishmania mexicana | LmxM.30.0460b | |
Trypanosoma cruzi | TcCLB.509237.120 | cysteine peptidase, Clan CA, family C2, putative |
Trypanosoma cruzi | TcCLB.508555.50 | calpain-like cysteine peptidase, putative |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Leishmania major | calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative | Compounds | References |
Species | Target | Length | Identity | Alignment span | Linked Drugs | Reference |
---|---|---|---|---|---|---|
Leishmania major | calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative | 687 aa | 33.1% | 676 aa | Compounds | References |
Leishmania major | small myristoylated protein-3, putative | 115 aa | 26.3% | 95 aa | Compounds | References |
Leishmania major | calpain family cysteine protease-like protein | 705 aa | 35.6% | 671 aa | Compounds | References |
Leishmania major | calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative | 414 aa | 28.7% | 418 aa | Compounds | References |