pI: 6.6778 |
Length (AA): 863 |
MW (Da): 95154 |
Paralog Number:
2
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 8
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 4 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
2 | 774 | 3ar4 (A) | 172 | 991 | 24.00 | 0.0000000025 | 1 | 1.05311 | 0.75 |
5 | 761 | 3ar4 (A) | 175 | 978 | 30.00 | 0 | 1 | 1.10167 | 0.07 |
397 | 559 | 3a1c (A) | 543 | 666 | 43.00 | 0 | 1 | 0.303376 | 0.97 |
488 | 555 | 4dw8 (A) | 192 | 263 | 37.00 | 0.01 | 0.7 | 0.453295 | -0.23 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_126645)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT3G22910 | putative calcium-transporting ATPase 13 |
Arabidopsis thaliana | AT4G29900 | calcium-transporting ATPase 10 |
Arabidopsis thaliana | AT3G57330 | putative calcium-transporting ATPase 11 |
Arabidopsis thaliana | AT5G57110 | calcium-transporting ATPase 8 |
Arabidopsis thaliana | AT3G63380 | putative calcium-transporting ATPase 12 |
Arabidopsis thaliana | AT5G53010 | putative calcium-transporting ATPase |
Arabidopsis thaliana | AT3G21180 | calcium-transporting ATPase 9 |
Arabidopsis thaliana | AT2G22950 | putative calcium-transporting ATPase 7 |
Arabidopsis thaliana | AT1G27770 | autoinhibited Ca2+-ATPase 1 |
Arabidopsis thaliana | AT4G37640 | calcium-transporting ATPase 2 |
Arabidopsis thaliana | AT2G41560 | autoinhibited Ca(2+)-ATPase 4 |
Brugia malayi | Bm1_54565 | Membrane calcium atpase protein 3 |
Brugia malayi | Bm1_24355 | calcium ATPase |
Candida albicans | CaO19.9295 | possible calcium transporter |
Candida albicans | CaO19.1727 | possible calcium transporter |
Caenorhabditis elegans | CELE_W09C2.3 | Protein MCA-1, isoform A |
Caenorhabditis elegans | CELE_Y67D8C.10 | Protein MCA-3, isoform C |
Caenorhabditis elegans | CELE_R05C11.3 | Protein MCA-2 |
Dictyostelium discoideum | DDB_G0289473 | P-type ATPase |
Dictyostelium discoideum | DDB_G0277861 | P-type ATPase |
Drosophila melanogaster | Dmel_CG42314 | plasma membrane calcium ATPase |
Echinococcus granulosus | EgrG_001191500 | plasma membrane calcium transporting ATPase 2 |
Echinococcus granulosus | EgrG_001081900 | plasma membrane calcium transporting ATPase |
Echinococcus granulosus | EgrG_000790100 | Ca2 transporting ATPase plasma membrane |
Entamoeba histolytica | EHI_030830 | Plasma membrane calcium-transporting ATPase, putative |
Entamoeba histolytica | EHI_136610 | plasma membrane calcium ion-transporting ATPase, putative |
Entamoeba histolytica | EHI_159040 | plasma membrane calcium ion-transporting ATPase, putative |
Entamoeba histolytica | EHI_001160 | plasma membrane calcium-transporting ATPase, putative |
Entamoeba histolytica | EHI_054830 | Plasma membrane calcium-transporting ATPase, putative |
Entamoeba histolytica | EHI_016480 | Plasma membrane calcium-transporting ATPase, putative |
Entamoeba histolytica | EHI_001150 | plasma membrane calcium-transporting ATPase 1, putative |
Echinococcus multilocularis | EmuJ_001191500 | Tetracycline resistance leader peptide, TetL |
Echinococcus multilocularis | EmuJ_001081900 | plasma membrane calcium transporting ATPase |
Echinococcus multilocularis | EmuJ_000790100 | Ca2+ transporting ATPase plasma membrane |
Giardia lamblia | GL50803_32658 | Plasma membrane calcium-transporting ATPase 2 |
Homo sapiens | ENSG00000070961 | ATPase, Ca++ transporting, plasma membrane 1 |
Homo sapiens | ENSG00000058668 | ATPase, Ca++ transporting, plasma membrane 4 |
Homo sapiens | ENSG00000067842 | ATPase, Ca++ transporting, plasma membrane 3 |
Homo sapiens | ENSG00000157087 | ATPase, Ca++ transporting, plasma membrane 2 |
Leishmania braziliensis | LbrM.07.0720 | vacuolar-type Ca2 -ATPase, putative |
Leishmania braziliensis | LbrM.07.0700 | vacuolar-type Ca2 -ATPase, putative |
Leishmania braziliensis | LbrM.17.0590 | P-type ATPase, putative |
Leishmania donovani | LdBPK_170660.1 | P-type ATPase, putative |
Leishmania infantum | LinJ.07.0700 | vacuolar-type Ca2 -ATPase, putative |
Leishmania infantum | LinJ.07.0510 | vacuolar-type Ca2 -ATPase, putative |
Leishmania infantum | LinJ.17.0660 | P-type ATPase, putative |
Leishmania major | LmjF.07.0630 | vacuolar-type Ca2 -ATPase, putative |
Leishmania major | LmjF.17.0600 | P-type ATPase, putative |
Leishmania major | LmjF.07.0650 | vacuolar-type Ca2 -ATPase, putative |
Leishmania mexicana | LmxM.07.0630 | vacuolar-type Ca2 -ATPase, putative |
Leishmania mexicana | LmxM.07.0650 | vacuolar-type Ca2 -ATPase, putative |
Leishmania mexicana | LmxM.17.0600 | P-type ATPase, putative |
Loa Loa (eye worm) | LOAG_08796 | hypothetical protein |
Loa Loa (eye worm) | LOAG_14416 | calcium ATPase |
Loa Loa (eye worm) | LOAG_06447 | calcium ATPase |
Loa Loa (eye worm) | LOAG_05573 | hypothetical protein |
Loa Loa (eye worm) | LOAG_05574 | hypothetical protein |
Mus musculus | ENSMUSG00000030302 | ATPase, Ca++ transporting, plasma membrane 2 |
Mus musculus | 101056241 | predicted gene, 29808 |
Mus musculus | ENSMUSG00000026463 | ATPase, Ca++ transporting, plasma membrane 4 |
Mus musculus | ENSMUSG00000019943 | ATPase, Ca++ transporting, plasma membrane 1 |
Mus musculus | ENSMUSG00000031376 | ATPase, Ca++ transporting, plasma membrane 3 |
Neospora caninum | NCLIV_033380 | hypothetical protein |
Neospora caninum | NCLIV_055720 | hypothetical protein |
Oryza sativa | 4331984 | Os03g0203700 |
Oryza sativa | 9267724 | Os08g0517200 |
Oryza sativa | 4351449 | Os12g0136900 |
Oryza sativa | 4352664 | Os12g0586600 |
Oryza sativa | 4328480 | Os02g0176700 |
Oryza sativa | 4333451 | Os03g0616400 |
Oryza sativa | 4326507 | Os01g0939100 |
Oryza sativa | 4349735 | Os11g0140400 |
Oryza sativa | 4336912 | Os04g0605500 |
Oryza sativa | 4339199 | Os05g0495600 |
Saccharomyces cerevisiae | YGL006W | calcium-transporting ATPase PMC1 |
Schistosoma japonicum | Sjp_0313890 | Plasma membrane calcium-transporting ATPase 3, putative |
Schistosoma japonicum | Sjp_0086060 | Plasma membrane calcium-transporting ATPase 3, putative |
Schistosoma japonicum | Sjp_0079000 | Plasma membrane calcium-transporting ATPase 2, putative |
Schistosoma japonicum | Sjp_0009630 | ko:K05850 Ca2+ transporting ATPase, plasma membrane, putative |
Schistosoma japonicum | Sjp_0109420 | Plasma membrane calcium-transporting ATPase 3, putative |
Schistosoma japonicum | Sjp_0204190 | Plasma membrane calcium-transporting ATPase 3, putative |
Schistosoma mansoni | Smp_176130 | plasma membrane calcium-transporting atpase |
Schistosoma mansoni | Smp_137170 | plasma membrane calcium-transporting atpase |
Schmidtea mediterranea | mk4.026656.00 | |
Schmidtea mediterranea | mk4.021433.00 | |
Schmidtea mediterranea | mk4.025718.00 | |
Schmidtea mediterranea | mk4.024061.00 | |
Schmidtea mediterranea | mk4.019468.00 | |
Schmidtea mediterranea | mk4.048418.00 | |
Schmidtea mediterranea | mk4.019772.01 | Plasma membrane calcium ATPase |
Schmidtea mediterranea | mk4.019940.01 | Plasma membrane calcium-transporting atpase,putative |
Schmidtea mediterranea | mk4.000119.04 | |
Schmidtea mediterranea | mk4.000320.06 | Plasma membrane calcium ATPase |
Schmidtea mediterranea | mk4.009491.00 | |
Schmidtea mediterranea | mk4.000220.10 | |
Schmidtea mediterranea | mk4.024698.05 | Plasma membrane calcium ATPase |
Schmidtea mediterranea | mk4.003018.04 | Putative plasma membrane calcium-transporting atpase |
Schmidtea mediterranea | mk4.026656.01 | |
Schmidtea mediterranea | mk4.019784.01 | |
Schmidtea mediterranea | mk4.031494.01 | |
Schmidtea mediterranea | mk4.000220.11 | |
Schmidtea mediterranea | mk4.068555.00 | Plasma membrane calcium ATPase |
Schmidtea mediterranea | mk4.024044.00 | Plasma membrane calcium ATPase |
Schmidtea mediterranea | mk4.006353.01 | |
Schmidtea mediterranea | mk4.031494.00 | |
Schmidtea mediterranea | mk4.024825.00 | |
Trypanosoma brucei gambiense | Tbg972.8.740 | vacuolar-type Ca2 -ATPase, putative |
Trypanosoma brucei | Tb927.8.1160 | vacuolar-type Ca2+-ATPase, putative |
Trypanosoma brucei | Tb927.8.1180 | vacuolar-type Ca2+-ATPase 1 |
Trypanosoma brucei | Tb927.8.1200 | vacuolar-type Ca2+-ATPase 2 |
Trypanosoma congolense | TcIL3000_8_780 | vacuolar-type Ca2+-ATPase, putative |
Trypanosoma congolense | TcIL3000_8_810 | vacuolar-type Ca2+-ATPase, putative |
Trypanosoma congolense | TcIL3000_0_19160 | vacuolar-type Ca2+-ATPase, putative |
Trypanosoma cruzi | TcCLB.508543.90 | plasma membrane Ca2+ ATPase |
Trypanosoma cruzi | TcCLB.506401.170 | plasma membrane Ca2+ ATPase |
Toxoplasma gondii | TGME49_312100 | plasma membrane-type Ca(2+)-ATPase A1 PMCAA1 |
Toxoplasma gondii | TGME49_233770 | calcium-translocating P-type ATPase, PMCA-type protein |
Trichomonas vaginalis | TVAG_074420 | cation-transporting ATPase fungi, putative |
Trichomonas vaginalis | TVAG_460580 | plasma membrane calcium-transporting ATPase, putative |
Trichomonas vaginalis | TVAG_001610 | plasma membrane calcium-transporting ATPase, putative |
Trichomonas vaginalis | TVAG_343600 | plasma membrane calcium-transporting ATPase, putative |
Trichomonas vaginalis | TVAG_034600 | plasma membrane calcium-transporting ATPase, putative |
Trichomonas vaginalis | TVAG_348080 | plasma membrane calcium-transporting ATPase, putative |
Trichomonas vaginalis | TVAG_277590 | cation-transporting ATPase, putative |
Trichomonas vaginalis | TVAG_178030 | plasma membrane calcium-transporting ATPase, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.8.1160 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.8.1160 | Trypanosoma brucei | significant gain of fitness in bloodstream forms (6 days) | alsford |
Tb927.8.1160 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb927.8.1160 | Trypanosoma brucei | significant gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
CELE_W09C2.3 | Caenorhabditis elegans | slow growth | wormbase |
CELE_Y67D8C.10 | Caenorhabditis elegans | adult lethal | wormbase |
CELE_Y67D8C.10 | Caenorhabditis elegans | embryonic arrest | wormbase |
CELE_R05C11.3 | Caenorhabditis elegans | slow growth | wormbase |
CELE_R05C11.3 | Caenorhabditis elegans | sterile | wormbase |
TGME49_233770 | Toxoplasma gondii | Probably non-essential | sidik |
TGME49_312100 | Toxoplasma gondii | Probably non-essential | sidik |
TGME49_233770 | Toxoplasma gondii | Probably essential | sidik |
TGME49_312100 | Toxoplasma gondii | Probably essential | sidik |
TGME49_233770 | Toxoplasma gondii | Essentiality uncertain | sidik |
TGME49_312100 | Toxoplasma gondii | Essentiality uncertain | sidik |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Trypanosoma cruzi | plasma membrane Ca2+ ATPase | Compounds | References |
Trypanosoma cruzi | plasma membrane Ca2+ ATPase | Compounds | References |
Schistosoma mansoni | plasma membrane calcium-transporting atpase | Compounds | References |